※ をクリックすると外部の論文のサイトが開きます。
論文
- タイトル
- タイトル（英）
- Genome-Wide Association Study Identifies Candidate Loci Associated with Opioid Analgesic Requirements in the Treatment of Cancer Pain
- 参照URL
- https://researchmap.jp/kazutakaikeda/published_papers/40633125
- 著者
- 著者（英）
- Daisuke Nishizawa,Takeshi Terui,Kunihiko Ishitani,Shinya Kasai,Junko Hasegawa,Kyoko Nakayama,Yuko Ebata,Kazutaka Ikeda
- 担当区分
- 概要
- 概要（英）
- Considerable individual differences have been widely observed in the sensitivity to opioids. We conducted a genome-wide association study (GWAS) in patients with cancer pain to identify potential candidate single-nucleotide polymorphisms (SNPs) that contribute to individual differences in opioid analgesic requirements in pain treatment by utilizing whole-genome genotyping arrays with more than 650,000 markers. The subjects in the GWAS were 428 patients who provided written informed consent and underwent treatment for pain with opioid analgesics in a palliative care unit at Higashi-Sapporo Hospital. The GWAS showed two intronic SNPs, rs1283671 and rs1283720, in the ANGPT1 gene that encodes a secreted glycoprotein that belongs to the angiopoietin family. These two SNPs were strongly associated with average daily opioid requirements for the treatment of pain in both the additive and recessive models (p < 5.0000 × 10−8). Several other SNPs were also significantly associated with the phenotype. In the gene-based analysis, the association was significant for the SLC2A14 gene in the additive model. These results indicate that these SNPs could serve as markers that predict the efficacy of opioid analgesics in cancer pain treatment. Our findings may provide valuable information for achieving satisfactory pain control and open new avenues for personalized pain treatment.
- 出版者・発行元
- 出版者・発行元（英）
- MDPI AG
- 誌名
- 誌名（英）
- Cancers
- 巻
- 14
- 号
- 19
- 開始ページ
- 4692
- 終了ページ
- 4692
- 出版年月
- 2022年9月27日
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.3390/cancers14194692
- 共同研究・競争的資金等の研究課題