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論文
- タイトル
- タイトル（英）
- Role for μ-opioid receptor in antidepressant effects of δ-opioid receptor agonist KNT-127
- 参照URL
- https://researchmap.jp/read0201960/published_papers/41209895
- 著者
- 著者（英）
- Yuki Moriya,Yoshiyuki Kasahara,Masafumi Shimada,Yasufumi Sakakibara,Hideaki Fujii,Hiroshi Nagase,Soichiro Ide,Kazutaka Ikeda,F. Scott Hall,George R. Uhl,Ichiro Sora
- 担当区分
- 概要
- 概要（英）
- Previous pharmacological data have shown the possible existence of functional interactions between μ- (MOP), κ- (KOP), and δ-opioid receptors (DOP) in pain and mood disorders. We previously reported that MOP knockout (KO) mice exhibit a lower stress response compared with wildtype (WT) mice. Moreover, DOP agonists have been shown to exert antidepressant-like effects in numerous animal models. In the present study, the tail suspension test (TST) and forced swim test (FST) were used to examine the roles of MOP and DOP in behavioral despair. MOP-KO mice and WT mice were treated with KNT-127 (10 mg/kg), a selective DOP agonist. The results indicated a significant decrease in immobility time in the KNT-127 group compared with the saline group in all genotypes in both tests. In the saline groups, immobility time significantly decreased in MOP-KO mice compared with WT mice in both tests. In female MOP-KO mice, KNT-127 significantly decreased immobility time in the TST compared with WT mice. In male MOP-KO mice, however, no genotypic differences were found in the TST after either KNT-127 or saline treatment. Thus, at least in the FST and TST, the activation of DOP and absence of MOP had additive effects in reducing measures of behavioral despair, suggesting that effects on this behavior by DOP activation occur independently of MOP.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Journal of Pharmacological Sciences
- 巻
- 151
- 号
- 3
- 開始ページ
- 135
- 終了ページ
- 141
- 出版年月
- 2023年3月
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 1347-8613
- DOI URL
- https://doi.org/10.1016/j.jphs.2022.12.008
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