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論文
- タイトル
- タイトル（英）
- Clinical relevance of macroglossia to disease progression in ventilation dependent patients with advanced ALS.
- 参照URL
- https://researchmap.jp/matsuda.c/published_papers/41364230
- 著者
- 著者（英）
- Chiharu Matsuda,Toshio Shimizu,Yuki Nakayama,Michiko Haraguchi,Chiyoko Hakuta,Rena Hidaka,Akira Nishiyama,Takaya Numayama
- 担当区分
- 概要
- 概要（英）
- BACKGROUND: Macroglossia is one of the clinical signs that emerges in patients with amyotrophic lateral sclerosis (ALS) who are undergoing invasive ventilation. OBJECTIVE: We aimed to investigate the relationship between the progression of macroglossia and the clinical characteristics during the advanced stages of ALS. METHODS: Forty-one patients with ALS using invasive ventilation with tracheostomy were prospectively followed over a 3-year period. We evaluated the prevalence of macroglossia, motor disabilities including oral function, communication ability (communication stage I to V) as a marker of disease progression, and nutritional factors. We analyzed the potential factors affecting the progression of macroglossia using a multivariate logistic analysis. RESULTS: The number of patients with macroglossia was increased during the follow-up (from 24.4 to 53.7%), while the communication stage progressed from 2.6 in average (SD 1.7) to 3.5 (1.4). During the study, body weight increased, while energy intake decreased, suggesting progressive hypometabolism. Eight patients had newly developed macroglossia during the study and showed greater progression of communication impairment than those without macroglossia. Multivariate logistic regression analysis showed that communication impairment was a factor associated with macroglossia. CONCLUSION: Macroglossia in advanced ALS with invasive ventilation is associated with disease progression.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
- 巻
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2023年1月30日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1007/s10072-023-06646-7
- 共同研究・競争的資金等の研究課題