{"id":4080,"date":"2024-08-15T11:13:59","date_gmt":"2024-08-15T02:13:59","guid":{"rendered":"https:\/\/www.igakuken.or.jp\/genome?post_type=new_publication&#038;p=4080"},"modified":"2024-08-15T11:13:59","modified_gmt":"2024-08-15T02:13:59","slug":"%e5%b1%b1%e8%b6%8a%e9%99%bd%e5%ad%90%e5%85%88%e7%94%9f%e3%81%ae%e3%82%b0%e3%83%ab%e3%83%bc%e3%83%97%e3%81%a8%e3%81%aeg4%e3%83%aa%e3%82%ac%e3%83%b3%e3%83%89%e3%81%ab%e9%96%a2%e3%81%99%e3%82%8b%e5%85%b1","status":"publish","type":"new_publication","link":"https:\/\/www.igakuken.or.jp\/genome\/?new_publication=%e5%b1%b1%e8%b6%8a%e9%99%bd%e5%ad%90%e5%85%88%e7%94%9f%e3%81%ae%e3%82%b0%e3%83%ab%e3%83%bc%e3%83%97%e3%81%a8%e3%81%aeg4%e3%83%aa%e3%82%ac%e3%83%b3%e3%83%89%e3%81%ab%e9%96%a2%e3%81%99%e3%82%8b%e5%85%b1","title":{"rendered":"\u5c71\u8d8a\u967d\u5b50\u5148\u751f\u306e\u30b0\u30eb\u30fc\u30d7\u3068\u306eG4\u30ea\u30ac\u30f3\u30c9\u306b\u95a2\u3059\u308b\u5171\u540c\u7814\u7a76\u304cChemical &#038; Biomedical Imaging\u8a8c\u306b\u30a2\u30af\u30bb\u30d7\u30c8\u3055\u308c\u307e\u3057\u305f"},"content":{"rendered":"<div class=\"entry-meta\"><span style=\"font-size: 14.08px;\">2024\u5e748\u670814\u65e5<\/span><\/div>\n<div class=\"entry-content post-content\">\n<div><span lang=\"EN-US\">ETH Z\u00fcrich\u306e\u5c71\u8d8a\u967d\u5b50\u5148\u751f\u306e\u30b0\u30eb\u30fc\u30d7\u3068\u306eG4\u30ea\u30ac\u30f3\u30c9\u306b\u95a2\u3059\u308b\u5171\u540c\u7814\u7a76\u304cChemical &amp; Biomedical Imaging\u8a8c\u306b\u30a2\u30af\u30bb\u30d7\u30c8\u3055\u308c\u307e\u3057\u305f<\/span><\/div>\n<div><\/div>\n<\/div>\n<p>Title: &#8220;Water-Soluble Mn(III)-Porphyrins with High Relaxivity and Photosensitization&#8221;<\/p>\n<p>Author(s): Nemeth, Tamas; Pallier, Agnes; \u00c7elik, \u00c7etin; garda, zoltan; Yoshizawa-Sugata, Naoko; Masai, Hisao; T\u00f3th, \u00c9va; Yamakoshi, Yoko<\/p>\n<p><span class=\"BDAbstractTitleChar\" style=\"font-size: 14.08px;\"><span lang=\"EN-US\"><strong>ABSTRACT<\/strong>:<\/span><\/span><span lang=\"EN-US\" style=\"font-size: 14.08px;\"> Three water-soluble Mn(III)-porphyrin complexes with cationic pyridyl side groups bearing COOH- or OH-terminated carbon chains in the <i>meta <\/i>or<i> para <\/i>positions have been synthesized as probes for both magnetic resonance imaging (MRI) and photodynamic therapy (PDT). The complexes <b>Mn-1<\/b>, <b>Mn-2<\/b>, and<b> Mn-3 <\/b>are highly water-soluble, and their relaxivities range between 10-15 mM<sup>-1<\/sup>s<sup>-1<\/sup>, at 20-80 MHz and 298K, 2-3 times higher than that of commercial Gd(III)-based agents. The complexes containing carboxylate (<b>Mn-2<\/b>)<b> <\/b>or<b> <\/b>alcoholic<b> <\/b>(<b>Mn-3<\/b>)<b> <\/b>side chains in <i>para<\/i> position are endowed with higher relaxivities and have also shown efficient photoinduced DNA cleavage and singlet oxygen (<sup>1<\/sup>O<sub>2<\/sub>) generation. <b>Mn-3<\/b> with stronger photoinduced DNA cleavage has also revealed stabilizing and binding activities for G4 DNA, at a similar level as the known G4 binder<b> Mn-TMPyP4<\/b>. Nevertheless, the G4-binding activity of <b>Mn-3 <\/b>was non-specific. Preliminary tests evidenced photocytotoxicity of<b> Mn-3<\/b> on HeLa cells without significant effect in the absence of light. Altogether, these results underline the potential of such water-soluble Mn(III)-porphyrins for the development of multimodal approaches combining MRI and PDT.<\/span><\/p>\n","protected":false},"featured_media":0,"template":"","_links":{"self":[{"href":"https:\/\/www.igakuken.or.jp\/genome\/index.php?rest_route=\/wp\/v2\/new_publication\/4080"}],"collection":[{"href":"https:\/\/www.igakuken.or.jp\/genome\/index.php?rest_route=\/wp\/v2\/new_publication"}],"about":[{"href":"https:\/\/www.igakuken.or.jp\/genome\/index.php?rest_route=\/wp\/v2\/types\/new_publication"}],"wp:attachment":[{"href":"https:\/\/www.igakuken.or.jp\/genome\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4080"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}