{"id":4125,"date":"2025-02-04T20:07:56","date_gmt":"2025-02-04T11:07:56","guid":{"rendered":"https:\/\/www.igakuken.or.jp\/genome\/?post_type=new_publication&#038;p=4125"},"modified":"2025-07-28T20:17:16","modified_gmt":"2025-07-28T11:17:16","slug":"%e5%b1%b1%e8%b6%8a%e9%99%bd%e5%ad%90%e5%85%88%e7%94%9f%e3%81%a8%e3%81%ae%e5%85%b1%e5%90%8c%e7%a0%94%e7%a9%b6%e3%82%92%e5%a0%b1%e5%91%8a%e3%81%97%e3%81%be%e3%81%97%e3%81%9f","status":"publish","type":"new_publication","link":"https:\/\/www.igakuken.or.jp\/genome\/?new_publication=%e5%b1%b1%e8%b6%8a%e9%99%bd%e5%ad%90%e5%85%88%e7%94%9f%e3%81%a8%e3%81%ae%e5%85%b1%e5%90%8c%e7%a0%94%e7%a9%b6%e3%82%92%e5%a0%b1%e5%91%8a%e3%81%97%e3%81%be%e3%81%97%e3%81%9f","title":{"rendered":"\u5c71\u8d8a\u967d\u5b50\u5148\u751f\u3068\u306e\u5171\u540c\u7814\u7a76\u3092\u5831\u544a\u3057\u307e\u3057\u305f"},"content":{"rendered":"<p>2025\u5e742\u67084\u65e5<\/p>\n<p>ETH Z\u00fcrich\u306e\u5c71\u8d8a\u967d\u5b50\u5148\u751f\u3068\u306e\u5171\u540c\u7814\u7a76\u3092\u3001ACS Pharmacol Transl Sci\u8a8c\u306b\u767a\u8868\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>LDL\u306f\u8102\u8cea\u904b\u642c\u306e\u4e3b\u6210\u5206\u3067\u3042\u308a\u3001\u52d5\u8108\u786c\u5316\u306e\u4e3b\u8981\u56e0\u3068\u306a\u308b\u3002\u305d\u306e\u6027\u8cea\u3092\u5229\u7528\u3057\u3001\u30d7\u30e9\u30fc\u30af\u90e8\u4f4d\u306e\u9078\u629e\u7684\u691c\u51fa\u3092\u76ee\u7684\u3068\u3057\u305fLDL\u30d9\u30fc\u30b9\u306eMRI\u30b3\u30f3\u30c8\u30e9\u30b9\u30c8\u5264\uff08nLDL\u3068sLDL\uff09\u3092\u958b\u767a\u3002\u5b9f\u9a13\u3067\u306f\u3001\u52d5\u8108\u786c\u5316\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3084\u7d30\u80de\u5b9f\u9a13\u3092\u901a\u3058\u3001LDL\u4fee\u98fe\u5264\u304c\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u3088\u308b\u53d6\u308a\u8fbc\u307f\u3092\u4ecb\u3057\u3066\u52d5\u8108\u786c\u5316\u30d7\u30e9\u30fc\u30af\u691c\u51fa\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002\u7279\u306bsLDL\u306fGd(III)-\u30ad\u30ec\u30fc\u30c8\u5206\u5b50\u306e\u9ad8\u3044\u642d\u8f09\u80fd\u529b\u3092\u6709\u3057\u3001\u52d5\u8108\u786c\u5316\u306e\u65e9\u671f\u8a3a\u65ad\u306b\u6709\u671b\u306a\u30c4\u30fc\u30eb\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u305f\u3002<\/p>\n<p>Fracassi A, Qiao H, Lowell AN, Cao J, Bode JW, Masai H, Yoshizawa-Sugata N, Zhou R, Yamakoshi Y. Natural and Synthetic LDL-Based Imaging Probes for the Detection of Atherosclerotic Plaques. ACS Pharmacol Transl Sci. 2025 Feb 4;8(2):578-591. doi: 10.1021\/acsptsci.4c00667. PMID: 39974638; PMCID: PMC11833727.<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39974638\/\">\u8ad6\u6587\u306f\u3053\u3053\u304b\u3089\u3002<\/a><\/p>\n","protected":false},"featured_media":0,"template":"","_links":{"self":[{"href":"https:\/\/www.igakuken.or.jp\/genome\/index.php?rest_route=\/wp\/v2\/new_publication\/4125"}],"collection":[{"href":"https:\/\/www.igakuken.or.jp\/genome\/index.php?rest_route=\/wp\/v2\/new_publication"}],"about":[{"href":"https:\/\/www.igakuken.or.jp\/genome\/index.php?rest_route=\/wp\/v2\/types\/new_publication"}],"wp:attachment":[{"href":"https:\/\/www.igakuken.or.jp\/genome\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4125"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}