{"id":4126,"date":"2025-08-21T08:26:42","date_gmt":"2025-08-20T23:26:42","guid":{"rendered":"https:\/\/www.igakuken.or.jp\/genome\/?post_type=new_publication&#038;p=4126"},"modified":"2025-09-21T08:28:14","modified_gmt":"2025-09-20T23:28:14","slug":"4126","status":"publish","type":"new_publication","link":"https:\/\/www.igakuken.or.jp\/genome\/?new_publication=4126","title":{"rendered":"Yang\u535a\u58eb\u306e\u8ad6\u6587\u304cbioRxiv\u306b\u516c\u958b\u3055\u308c\u307e\u3057\u305f"},"content":{"rendered":"<p>2025\u5e748\u670821\u65e5<\/p>\n<p>Yang\u541b\u306e\u8ad6\u6587<\/p>\n<p><strong>Phosphorylation of Claspin by elF2alpha kinase protects cells from heat stress<\/strong><\/p>\n<p>\u304c bioRxiv\u306b\u30dd\u30b9\u30c8\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u3053\u306e\u8ad6\u6587\u3067\u306f\u3001\u71b1\u30b7\u30e7\u30c3\u30af\u304c\u3001Claspin\u3092\u4ecb\u3057\u3066DNA\u8907\u88fd\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3001\u307e\u305f\u305d\u306e\u6642\u3001Integrative Stress Reponse\u7d4c\u8def\u306b\u4f9d\u5b58\u3059\u308b\u3053\u3068\u3001\u3055\u3089\u306b\u3001ISR\u3067\u5fc5\u9808\u306e\u5f79\u5272\u3092\u679c\u305f\u3059eIF2alpha kinase\u3067\u3042\u308bGCN2, HIR\u304cClaspin\u306eC\u672b\u3092\u30ea\u30f3\u9178\u5316\u3059\u308b\u3053\u3068\u304c\u5fc5\u9808\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3001\u3055\u3089\u306b\u305d\u306e\u30ea\u30f3\u9178\u5316\u306e\u5f79\u5272\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u73fe\u5728\u67fb\u8aad\u4e2d\u3067\u3059\u3002<\/p>\n<p>bioRxiv\u306e\u30ea\u30f3\u30af\u306f\u4e0b\u8a18\u3067\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.biorxiv.org\/cgi\/content\/short\/2025.08.21.670878v1\">https:\/\/www.biorxiv.org\/cgi\/content\/short\/2025.08.21.670878v1<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"featured_media":0,"template":"","_links":{"self":[{"href":"https:\/\/www.igakuken.or.jp\/genome\/index.php?rest_route=\/wp\/v2\/new_publication\/4126"}],"collection":[{"href":"https:\/\/www.igakuken.or.jp\/genome\/index.php?rest_route=\/wp\/v2\/new_publication"}],"about":[{"href":"https:\/\/www.igakuken.or.jp\/genome\/index.php?rest_route=\/wp\/v2\/types\/new_publication"}],"wp:attachment":[{"href":"https:\/\/www.igakuken.or.jp\/genome\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4126"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}