{"id":119,"date":"2022-10-09T01:11:59","date_gmt":"2022-10-08T16:11:59","guid":{"rendered":"http:\/\/pnrm-d.com\/genome\/?page_id=119"},"modified":"2025-09-21T09:51:30","modified_gmt":"2025-09-21T00:51:30","slug":"biblography-3-2-2-2-2-2","status":"publish","type":"page","link":"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119","title":{"rendered":"\u767a\u8868\u8ad6\u6587"},"content":{"rendered":"<div id=\"toc-np-container\"><p id=\"toc-np-title\">Contents<\/p><ul class=\"no-bullets\"><li class=\"header-level-1\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#Original-Papers-2000---2025\">Original Papers (2000 - 2025)<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2025\">-2025-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2024\">-2024-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2023\">-2023-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2022\">-2022-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2021\">-2021-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2020\">-2020-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2019\">-2019-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2018\">-2018-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2017\">-2017-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2016\">-2016-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2015\">-2015-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2014\">-2014-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2013\">-2013-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2012\">-2012-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2011\">-2011-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2010\">-2010-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2009\">-2009-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2008\">-2008-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2007\">-2007-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2006\">-2006-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2005\">-2005-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2004\">-2004-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2003\">-2003-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2002\">-2002-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2001\">-2001-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2000\">-2000-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#1999\">-1999\u4ee5\u524d\u306e\u4e00\u90e8-<\/a><\/li><li class=\"header-level-1\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#Reviews-and-Book-chapters-in-English-only-To-view-crick-here-first\">Reviews and Book chapters (in English only) To view crick here first!<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#\"><\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2025\">-2025-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2024\">-2024-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2023\">-2023-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2022\">-2022-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2021\">-2021-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2020\">-2020-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2019\">-2019-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2018\">-2018-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2017\">-2017-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2016\">-2016-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2015\">-2015-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2014\">-2014-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2013\">-2013-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2012\">-2012-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2011\">-2011-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2010\">-2010-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2009\">-2009-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2008\">-2008-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2005\">-2005-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2004\">-2004-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2003\">-2003-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2002\">-2002-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2001\">-2001-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#2000\">-2000-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#1999\">-1999-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#1996\">-1996-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#1994\">-1994-<\/a><\/li><li class=\"header-level-2\"><a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119#1988\">-1988-<\/a><\/li><\/ul><\/div><h2>Original Papers (2000 &#8211; 2025)<\/h2>\n<h3><span id=\"2025\">-2025-<\/span><\/h3>\n<ol>\n<li>\n<div><span lang=\"EN-US\">Fracassi A, Qiao H, Lowell AN, Cao J, Bode JW, *<\/span><b><span lang=\"EN-US\">Masai H, <\/span><\/b><span lang=\"EN-US\">*<\/span><span lang=\"EN-US\">Yoshizawa-Sugata N, *<\/span><span lang=\"EN-US\">Zhou R, *<\/span><span lang=\"EN-US\">Yamakoshi Y. (2025) <\/span><\/div>\n<div><span lang=\"EN-US\">&#8220;<\/span><span lang=\"EN-US\">Natural and Synthetic LDL-Based Imaging Probes for the Detection of Atherosclerotic Plaques.<\/span><span style=\"font-size: 14.08px;\">&#8220;<\/span><\/div>\n<div><span lang=\"EN-US\"> <b><i>ACS Pharmacol Transl Sci<\/i><\/b>. 8:578-591.<\/span><\/div>\n<\/li>\n<li>Tanaya Y, Sashida M, <strong>Masai H<\/strong>, Sasanuma H, Miura D, Asano R, Nagasawa K, <span lang=\"EN-US\">*<\/span>Tera M. (2025) Evaluation of the effects of G4 ligands on the interaction between G-quadruplexes and their binding proteins. <strong><em>Chem Commun (Camb)<\/em><\/strong>. Jul 31;61(63):11790-11793. doi: 10.1039\/d5cc02801a.<\/li>\n<li>Chi-Chun Yang, Hidemasa Goto, Seiichi Oyadomari, *<strong>Hisao<\/strong> <strong>Masai <\/strong>(2025) &#8220;Regulation of Claspin by the elF2\u03b1 kinase protects cells from heat stress.&#8221; bioRxiv doi:https:\/\/doi.org\/10.1101\/2025.08.21.670878<\/li>\n<li><span style=\"font-size: 14.08px;\">Taku Tanaka, Yumika Seki, and *<\/span><strong style=\"font-size: 14.08px;\">Hisao Masai<\/strong><span style=\"font-size: 14.08px;\"> (2025) &#8220;<\/span><em style=\"font-size: 14.08px;\">dif<\/em><span style=\"font-size: 14.08px;\">-XerCD is required for chromosome segregation during cSDR-dependent growth in <\/span><em style=\"font-size: 14.08px;\"> coli<\/em><span style=\"font-size: 14.08px;\">&#8220;<\/span><em style=\"font-size: 14.08px;\"> <strong>bioRxiv<\/strong><\/em> doi:<span style=\"font-size: 14.08px;\">\u00a0https:\/\/doi.org\/10.1101\/2025.09.02.673814<\/span><\/li>\n<\/ol>\n<h3><span id=\"2024\">-2024-<\/span><\/h3>\n<ol>\n<li><span style=\"font-size: 14.079999923706055px;\">Zhiying You,Hao-Wen\u00a0Hsiao, Chi-Chun\u00a0Yang,\u00a0Hidemasa\u00a0Goto,\u00a0*<strong>Hisao<\/strong><strong>\u00a0<\/strong><strong>Masai<\/strong> (2024) \u201cPhosphorylation inhibits intramolecular interactions, DNA-binding and protein interactions of Claspin through disordered\/ structured conformation transition.\u201d <strong><em>BioRxiv<\/em><\/strong> doi:\u00a0<a href=\"https:\/\/doi.org\/10.1101\/2024.01.08.574761\">https:\/\/doi.org\/10.1101\/2024.01.08.574761<\/a>.<\/span><\/li>\n<li>*Shibata T, Ikawa S, Iwasaki W, Sasanuma H, <strong>Masai H<\/strong>, Hirota K. (2024) Homology recognition without double-stranded DNA-strand separation in D-loop formation by RecA. <strong><em>Nucleic Acids Res.<\/em><\/strong> 12:gkad1260. doi: 10.1093\/nar\/gkad1260. Epub ahead of print. PMID: 38214227.<\/li>\n<li>\n<div><span lang=\"EN-US\">Yamazaki K, Iguchi T, Kanoh Y, Takayasu K, Ngo TTT, Onuki A, Kawaji H, Oshima S, Kanda T, <b>Masai H<\/b>, <\/span><span lang=\"EN-US\">*<\/span><span lang=\"EN-US\">Sasanuma H. (2024) Homologous recombination contributes to the repair of acetaldehyde-induced DNA damage. <b><i>Cell Cycle<\/i><\/b>. 2024 Apr 3:1-16. doi: 10.1080\/15384101.2024.2335028. Epub ahead of print. PMID: 38571319<\/span><\/div>\n<\/li>\n<li>\n<div><span lang=\"EN-US\">Tajima Y, Shibasaki F, <\/span><span lang=\"EN-US\">*<\/span><b><span lang=\"EN-US\">Masai H. <\/span><\/b><span style=\"font-size: 14.08px;\">(2024) Cell fusion upregulates PD-L1 expression for evasion from immunosurveillance. <\/span><b style=\"font-size: 14.08px;\"><i>Cancer Gene Ther.<\/i><\/b><span style=\"font-size: 14.08px;\"> Jan;31(1):158-173.<\/span><\/div>\n<\/li>\n<li><span style=\"font-size: 14.079999923706055px;\"><span style=\"font-size: 14.079999923706055px;\"><span style=\"font-size: 14.08px;\">Charlton SJ, Flury V, Kanoh Y, Genzor AV, Kollenstart L, Ao W, Br\u00f8gger P, Weisser MB, Adamus M, Alcaraz N, Delvaux de Fenffe CM, Mattiroli F, Montoya G, <strong>Masai H<\/strong>, <span lang=\"EN-US\">*<\/span>Groth AJ and <span lang=\"EN-US\">*<\/span>Thon G <\/span><\/span><\/span><span style=\"font-size: 14.079999923706055px;\"><span style=\"font-size: 14.079999923706055px;\"><span style=\"font-size: 14.08px;\">(2024) <\/span><\/span><\/span><span style=\"font-size: 14.079999923706055px;\"><span style=\"font-size: 14.079999923706055px;\">\u201c<\/span><\/span><span style=\"font-size: 14.08px;\">The fork protection complex promotes parental histone recycling and epigenetic memory. \u201d <\/span><b style=\"font-size: 14.08px;\"><i>Cell<\/i><\/b><span style=\"font-size: 14.08px;\"> in press<\/span><\/li>\n<li>*Yoshizawa-Sugata N, <strong>Masai H.<\/strong>\u00a0(2023)Histone Modification Analysis of Low-Mappability Regions. <em><strong>Methods Mol. Biol.<\/strong><\/em> 2023;2519:163-185. doi: 10.1007\/978-1-0716-2433-3_18. PMID: 36066721.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<h3><span id=\"2023\">-2023-<\/span><\/h3>\n<ol>\n<li><span lang=\"EN-US\">Hao-Wen Hsiao<\/span><span lang=\"EN-US\">, Chi-Chun Yang, and <\/span><span lang=\"EN-US\"><span lang=\"EN-US\">*<strong>Hisao Masai<\/strong> (2023) &#8220;Claspin-dependent and -independent Chk1 activation by a panel of biological stresses.&#8221; <b><i>Biomolecules<\/i><\/b>,<\/span><\/span><span lang=\"EN-US\">13(1): 125.<\/span><\/li>\n<li><span style=\"font-size: 14.079999923706055px;\">Kanoh, Y.,\u00a0<\/span><span style=\"font-size: 14.079999923706055px;\">Matsumoto, S., Ueno, M., Hayano, M., Kudo<\/span><span style=\"font-size: 14.079999923706055px;\">, M., and *<\/span><strong style=\"font-size: 14.079999923706055px;\">Masai, H.<\/strong><span style=\"font-size: 14.079999923706055px;\"> (2023) &#8220;Aberrant association of chromatin with nuclear periphery induced by Rif1 leads to mitotic defect and cell death.&#8221; <\/span><strong style=\"font-size: 14.079999923706055px;\"><em>Life Science Alliance\u00a0<\/em><\/strong><span style=\"font-size: 14.079999923706055px;\">6(4):e202201603.<\/span><\/li>\n<li>Hori, K., Yamazaki, S., Maruyama, C., Iguchi, T. and <strong>*Masai. H.<\/strong> (2023) &#8220;Cdc7 kinase is required for postnatal brain development.&#8221; <strong><em>Genes to Cells<\/em><\/strong>, 28(10):679-693. DOI: 10.1111\/gtc.12216<\/li>\n<li>Yang, C-C., and *<strong>Masai, H.<\/strong> (2023) &#8220;Claspin is required for growth recovery from serum starvation through regulating the PI3K-PDK1-mTOR pathway in mammalian cells.&#8221; <strong><em> Cell. Biol.<\/em><\/strong> 43(1): 1-21.<\/li>\n<li><span style=\"font-size: 14.079999923706055px;\">Wendi Sun<\/span><strong style=\"font-size: 14.079999923706055px;\">*<\/strong><span style=\"font-size: 14.079999923706055px;\">, Kian Leong Lee<\/span><strong style=\"font-size: 14.079999923706055px;\">*<\/strong><span style=\"font-size: 14.079999923706055px;\">, Lorenz Poellinger, <strong>Hisao Masai<\/strong> and *<\/span>Hiroyuki Kato<span style=\"font-size: 14.079999923706055px;\">\u00a0(2023) &#8220;Catalytic domain-dependent and -independent transcriptional activities of the tumor suppressor histone H3K27 demethylase UTX\/KDM6A in specific cancer types.&#8221; <\/span><strong style=\"font-size: 14.079999923706055px;\"><em>Epigenetics\u00a0<span style=\"font-size: 14.079999923706055px; font-style: normal; font-weight: normal;\">18, 2222245.<\/span><\/em><\/strong><\/li>\n<li>\n<div><span lang=\"EN-US\">Tamas Nemeth, Naoko Yoshizawa-Sugata, Agnes Pallier, Youichi Tajima, \u00c9va T\u00f3th, <\/span><span lang=\"EN-US\">*<\/span><b><span lang=\"EN-US\">Hisao Masai<\/span><\/b><span lang=\"EN-US\">, and <\/span><span lang=\"EN-US\">*<\/span><span lang=\"EN-US\">Yoko Yamakoshi\u00a0<\/span><span lang=\"EN-US\" style=\"font-size: 14.079999923706055px;\">(2023) &#8220;<\/span><span lang=\"EN-US\" style=\"font-size: 14.079999923706055px;\">Water-Soluble Gd(III)-Porphyrin Complexes Capable of Both Photosensitization and Relaxation Enhancement<\/span><span lang=\"EN-US\" style=\"font-size: 14.079999923706055px;\">.&#8221; <\/span><b style=\"font-size: 14.079999923706055px;\"><i><span lang=\"EN-US\">Chemical &amp; Biomedical Imaging<\/span> <\/i><\/b><span lang=\"EN-US\" style=\"font-size: 14.079999923706055px;\">1(2):157-167.<\/span><\/div>\n<\/li>\n<li>*Yoshizawa-Sugata N, <strong>Masai H.<\/strong>\u00a0(2023)Histone Modification Analysis of Low-Mappability Regions. <em><strong>Methods Mol. Biol.<\/strong><\/em> 2023;2519:163-185. doi: 10.1007\/978-1-0716-2433-3_18. PMID: 36066721.<\/li>\n<\/ol>\n<h3><span id=\"2022\">-2022-<\/span><\/h3>\n<ol>\n<li>Tajima, Y., Shibasaki, F. and *<strong>Masai, H.<\/strong> (2022) &#8220;Cell fusion upregulates PD-L1 expression and promotes tumor formation.&#8221; <strong><em>Oncogene<\/em><\/strong> revised manuscript submitted (bioRxiv 2022.06.14.496068)<\/li>\n<li>Nakamura H, Sekine H, Kato H, <strong>Masai H<\/strong>, Gradin K, Poellinger L. Hypoxia-inducible factor-1\u03b1 and poly [ADP ribose] polymerase 1 cooperatively regulate Notch3 expression under hypoxia via a noncanonical mechanism. <strong><em>J Biol Chem.<\/em><\/strong> 2022 Jul;298(7):102137. doi: 10.1016\/j.jbc.2022.102137. Epub 2022 Jun 14. PMID: 35714766; PMCID: PMC9287808.<\/li>\n<\/ol>\n<h3><span id=\"2021\">-2021-<\/span><\/h3>\n<ol>\n<li>*Yoshizawa-Sugata, Y., Yamazaki, S., Mita-Yoshida, K., Ono, T., Nishito, Y., and *<strong>Masai, H.<\/strong> (2021) \u201cLoss of full-length Rif1 protein in 2-cell embryos is associated with zygotic transcriptional activation.\u201d <strong><em>J.\u00a0Biol. Chem.<\/em><\/strong>\u00a0297(6):101367<\/li>\n<li>Kitajima S, Sun W, Lee KL, Ho JC, Oyadomari S, Okamoto T, <strong>Masai H<\/strong>, Poellinger L, *Kato H. (2021) A KDM6 inhibitor potently induces ATF4 and its target gene expression through HRI activation and by UTX inhibition. <strong><em>Sci Rep.<\/em><\/strong> 11(1):4538.<\/li>\n<li>Nakamura K, Sakai S, Tsuyama J, Nakamura A, Otani K, Kurabayashi K, Yogiashi Y, <strong>Masai H<\/strong>, *Shichita T. Extracellular DJ-1 induces sterile inflammation in the ischemic brain. <strong><em>PLoS Biol.<\/em><\/strong> 2021 May 20;19(5):e3000939. doi: 10.1371\/journal.pbio.3000939. PMID: 34014921; PMCID: PMC8136727.<\/li>\n<li><span style=\"font-size: 14.079999923706055px;\">*Irie, T., Asami, T., Sawa, A., Uno, Y., Taniyama, C., Funakoshi, Y., <\/span><strong style=\"font-size: 14.079999923706055px;\">Masai, H.<\/strong><span style=\"font-size: 14.079999923706055px;\">, Sawa, M. (2021) \u201cDiscovery of AS-0141, a Potent and Selective Inhibitor of CDC7 Kinase for the Treatment of Solid Cancers.\u201d <strong><em>J.\u00a0<\/em><\/strong><\/span><strong style=\"font-size: 14.079999923706055px;\"><em> Med. Chem<\/em><\/strong><span style=\"font-size: 14.079999923706055px;\">. 64(19):14153-14164. doi: 10.1021\/acs.jmedchem.1c01319.<\/span><\/li>\n<\/ol>\n<h3><span id=\"2020\">-2020-<\/span><\/h3>\n<ol>\n<li><strong>*<\/strong><strong>Masai, H<\/strong>, Kanoh, Y, Kakusho, N, Fukatsu, R (2020) &#8220;Detection of cellular G-quadruplex by using a loop structure as a structural determinant.&#8221;\u00a0<strong><em>Biochemical and Biophysical Research Communications<\/em><\/strong>, 531:75-83.<\/li>\n<li><strong style=\"font-size: 14.079999923706055px;\">*<\/strong><span style=\"font-size: 14.079999923706055px;\">Kato H, Asamitsu K, Sun W, Kitajima S, Yoshizawa-Sugata N, Okamoto T, <\/span><strong style=\"font-size: 14.079999923706055px;\">Masai H<\/strong><span style=\"font-size: 14.079999923706055px;\">, Poellinger L. (2020) Cancer-derived UTX TPR mutations G137V and D336G impair interaction with MLL3\/4 complexes and affect UTX subcellular localization.\u00a0<\/span><strong style=\"font-size: 14.079999923706055px;\"><em>Oncogene<\/em><\/strong><span style=\"font-size: 14.079999923706055px;\">. doi: 10.1038\/s41388-020-1218-3. [Epub ahead of print] PubMed PMID: 32071397.<\/span><\/li>\n<li>Fracassi A, Cao J, Yoshizawa-Sugata N, Toth E, Archer C, Groninger O, Ricciotti E, S-Y Tang, Handschin S, Bourgeois J-P, Ray A, Liosi K, Oriana S, Stark W, <strong>Masai H<\/strong>, Zhou R, Yamakoshi Y (2020) \u201cLDL-mimetic lipid nanoparticles prepared by surface KAT ligation for in vivo MRI of atherosclerosis\u201d\u00a0<strong><em>Chem Sci<\/em><\/strong> in press<\/li>\n<li><span lang=\"EN-US\">Kitajima S, Sun W, Lee KL, Ho JC, Oyadomari S, Okamoto T, <b>Masai H<\/b>, Poellinger L, Kato H. (2021) A KDM6 inhibitor potently induces ATF4 and its target gene expression through HRI activation and by UTX inhibition. <b><i>Sci Rep.<\/i><\/b> 11(1):4538.<\/span><\/li>\n<\/ol>\n<h3><span id=\"2019\">-2019-<\/span><\/h3>\n<ol>\n<li>Yang, C-C., Kato, H., Shindo, M. and <strong>*Masai. H.<\/strong> (2019)&#8221;Cdc7 activates replication checkpoint by phosphorylating the Chk1 binding domain of Claspin in human cells.&#8221; <strong><em>E-life<\/em><\/strong>, 8. pii: e50796.<\/li>\n<li><strong>*Masai, H.<\/strong>, Fukatsu, R., Kakusho, N., Kanoh, Y., Moriyama, K., Ma, Y., Iida, K., Nagasawa, K. (2019) &#8220;Rif1 promotes self-association of G-quadruplex (G4) by its specific G4 binding and oligomerization activities.&#8221; <strong><em>Sci. Rep<\/em><\/strong><em>.<\/em>, 9(1), 8618.<\/li>\n<li>Kobayashi, S., Fukatsu, R., Kanoh, Y., Kakusho, N., Matsumoto, S., Chaen, S. and <strong>*Masai, H.<\/strong> (2019) &#8220;Both a unique motif at the C terminus and N-terminal HEAT repeat contribute to G4 binding and origin regulation by Rif1 protein.&#8221; <strong><em>Mol Cell. Biol.<\/em><\/strong>\u00a039,\u00a0pii: e00364-18.(cover figure)<\/li>\n<li><strong>*Masai, H.<\/strong>, Fukatsu, R., Kakusho, N., Kanoh, Y., Moriyama, K., Ma, Y., Iida, K., Nagasawa, K. (2019) &#8220;Rif1 promotes self-association of G-quadruplex (G4) by its specific G4 binding and oligomerization activities.&#8221;<strong><em>\u00a0Sci. Rep.<\/em><\/strong>, <i>\u00a09(1):18622.<\/i><\/li>\n<\/ol>\n<h3><span id=\"2018\">-2018-<\/span><\/h3>\n<ol>\n<li>Moriyama K, Yoshizawa-Sugata N, and\u00a0<strong>*Masai H<\/strong>\u00a0 (2018) Oligomer formation and G-quadruplex-binding by purified murine Rif1 protein, a key organizer of higher-order chromatin architecture. <em><strong>J Biol Chem.<\/strong><\/em> \u00a0pii: jbc.RA117.000446. doi: 10.1074\/jbc.RA117.000446. [Epub ahead of print] PubMed PMID: 29348174.<\/li>\n<li>Iguchi, T., Miyauchi, E., Watanabe, S., <strong>Masai, H.<\/strong> and <strong>*<\/strong>S. Miyatake (2018) &#8220;A BTB-ZF protein, ZNF131, is required for early B cell development.&#8221;\u00a0<strong><em>Biochemical and Biophysical Research Communications<\/em><\/strong>, 501, 70-575.<\/li>\n<li><strong>*<\/strong><strong>Masai, H.<\/strong>, Kakusho, N., Fukatsu, R., Ma, Y., Iida, K., Kanoh, Y. and Nagasawa, K. (2018) &#8220;Molecular architecture of G-quadruplex structures generated on duplex Rif1 binding.&#8221;\u00a0<strong><em>J Biol Chem.<\/em><\/strong> 293, 17033-17049.<\/li>\n<\/ol>\n<h3><span id=\"2017\">-2017-<\/span><\/h3>\n<ol>\n<li>*You, Z. and <strong>Masai, H.<\/strong> (2017) &#8220;Potent DNA strand annealing activity associated with mouse Mcm2~7 heterohexamer complex.&#8221;\u00a0<strong><em>Nucleic Acids Res<\/em><\/strong><strong>.<\/strong>\u00a045, :6494-6506. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28449043\">[Pubmed]<\/a><\/li>\n<li>Irie T, Asami T, Sawa A, Uno Y, Hanada M, Taniyama C, Funakoshi Y, <strong>Masai H,<\/strong> and *Sawa M. (2017) Discovery of novel furanone derivatives as potent Cdc7 kinase inhibitors.\u00a0<em><strong>Eur J Med Chem.<\/strong><\/em>\u00a0130, 406-418. doi: 10.1016\/j.ejmech.2017.02.030. Epub\u00a02017 Feb 17. PubMed PMID: 28279847.<\/li>\n<li>Matsumoto, S., Kanoh, Y., Shimmoto, M., Hayano, M., Ueda, K., Fukatsu, R., Kakusho, N., and <strong>*Masai, H.<\/strong> (2017) &#8220;Checkpoint-independent Regulation of Origin Firing by Mrc1 through Interaction with Hsk1 kinase.&#8221;\u00a0<strong><strong><em>Mol. Cell. Biol.\u00a0<\/em><\/strong><\/strong>\u00a0Mar 17;37(7). pii: e00355-16. doi: 10.1128\/MCB.00355-16. Print 2017 Apr 1.\u00a0PMID:\u00a028069740<\/li>\n<li><strong><em>\u00a0<\/em><\/strong>Toteva, T., Mason, B., Kanoh, Y. Br\u00f8gger, P. Green, D., Verhein-Hansen, J. <strong>Masai, H<\/strong>. and *Thon, G. (2017) &#8220;Establishment of expression-state boundaries by Rif1 and Taz1 in fission yeast.&#8221;\u00a0<em><strong>Proc. Natl. Acad. Sci. USA.<\/strong> <\/em>114, 1093-1098.<\/li>\n<\/ol>\n<h3><span id=\"2016\">-2016-<\/span><\/h3>\n<ol>\n<li>Yang, C-C., Suzuki, M., Yamakawa, S., Uno, S., Ishii, A., Yamazaki, S., Fukatsu, R., Fujisawa, R., Sakimura, K., Tsurimoto, T., and <strong>*<\/strong><strong>Masai, H.<\/strong> (2016) &#8220;Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells.&#8221;\u00a0<strong><em>Nature Communications<\/em><\/strong> 7:12135 doi: 10.1038\/ncomms12135.<\/li>\n<li>*Zhiying You, Koji L. Ode, Haruhiko Takisawa, and <strong>Hisao Masai<\/strong> (2015) &#8220;Characterization of conserved arginine residues on Cdt1 that affect licensing activity and interaction with Geminin or Mcm complex.&#8221;\u00a0<em><strong>Cell Cycle<\/strong><\/em>\u00a015:1213-26.<\/li>\n<li>Tanaka T, Nishito Y, *<strong>Masai H. <\/strong>(2016) &#8220;Fork restart protein, PriA, binds around oriC after depletion of nucleotide precursors: Replication fork arrest near the replication origin.&#8221;\u00a0<strong><em>Biochem. Biophys. Res. Commun.<\/em><\/strong> 470, 546-551.<\/li>\n<li>\u00a0Tanaka H, Muto A, Shima H, Katoh Y, Sax N, Tajima S, Brydun A, Ikura T, Yoshizawa N, <strong>Masai H<\/strong>, Hoshikawa Y, Noda T, Nio M, Ochiai K, *Igarashi K. (2016) &#8220;Epigenetic Regulation of the Blimp-1 Gene (Prdm1) in B Cells Involves Bach2 and Histone Deacetylase 3.&#8221; <strong><em>J. Biol. Chem.<\/em><\/strong> 291, 6316-6330.<\/li>\n<li>*Nonaka T, Suzuki G, Tanaka Y, Kametani F, Hirai S, Okado H, Miyashita T, Saitoe M, Akiyama H, <strong>Masai H<\/strong>, Hasegawa M. (2016) &#8220;Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1\u03b4 Triggers Mislocalization and Accumulation of TDP-43.&#8221;\u00a0<strong><em>J. Biol. Chem. <\/em><\/strong>291, 5473-5483.<\/li>\n<li>Kozel, C., Thompson, B., Hustak, S., Moore, C., Nakashima, A., Singh, C.R., Reid, M., Cox, C., Papadopoulos, E., Luna, R.E., Anderson, A., Tagami, H., Hiraishi, H., Slone, E.A., Yoshino, K.I., Asano, M., Gillaspie, S., Nietfeld, J., Perchellet, J.P., Rothenburg, S., <strong>Masai, H.<\/strong>, Wagner, G., Beeser, A., Kikkawa, U., Fleming, S.D., and *Asano, K. (2016) &#8220;Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation.&#8221;\u00a0<strong><em>Nucleic Acids Res. <\/em><\/strong>44, 8704-8713.<\/li>\n<\/ol>\n<h3><span id=\"2015\">-2015-<\/span><\/h3>\n<ol>\n<li>Yutaka Kanoh, Seiji Matsumoto, Rino Fukatsu, Naoko Kakusho, Nobuaki Kono, Claire Renard-Guillet, Koji Masuda, Keisuke Iida, Kazuo Nagasawa, Katsuhiko Shirahige, and <strong>*Hisao Masai<\/strong> (2015) Rif1 binds to G-quadruplex and suppresses replication over a long distances. <em><strong>Nature Structural &amp; Molecular Biology<\/strong><\/em> Article in press\u00a0<a href=\"http:\/\/http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26436827\">[PubMed]<\/a><\/li>\n<li>Zech J, Godfrey EL, Masai H, Hartsuiker E, Dalgaard JZ. (2015) &#8220;The DNA-Binding Domain of S. pombe Mrc1 (Claspin) Acts to Enhance Stalling at Replication Barriers.&#8221; <em><strong>PLoS One<\/strong>.<\/em> 10:e0132595.\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26201080\">[PubMed]<\/a><\/li>\n<li>Iguchi T, Aoki K, Ikawa T, Taoka M, Taya C, Yoshitani H, Toma-Hirano M, Koiwai O, Isobe T, Kawamoto H, Masai H, Miyatake S. (2015) &#8220;BTB-ZF Protein Znf131 Regulates Cell Growth of Developing and Mature T Cells.&#8221; <em><strong>J Immunol.<\/strong><\/em> \u00a0195, 982-993.\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26136427\">[PubMed]<\/a><\/li>\n<li>*Kotaro Koiwai, Takashi Kubota, Nobuhisa Watanabe, Katsutoshi Hori, Osamu Koiwai, and *Hisao Masai (2015)\u00a0&#8220;Definition of the transcription factor TdIF1 consensus binding sequence through genome-wide mapping of its binding sites.&#8221;\u00a0<em><strong>Genes to Cells<\/strong><\/em>\u00a020, 242-254.\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25619743\">[PubMed]<\/a><\/li>\n<li>Jeffery, D.C., Kakusho, N., You, Z., Gharib, M., Wyse, B., Drury, E., Weinreich, M., Thibault,\u00a0P., Verreault, A., Masai, H., and\u00a0*Yankulov, K. (2015) &#8220;CDC28 phosphorylates Cac1p and regulates the\u00a0association of chromatin assembly factor with chromatin.&#8221;\u00a0<em><strong>Cell Cycle<\/strong><\/em>\u00a014, 74-85.\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25602519\">[PubMed]<\/a><\/li>\n<\/ol>\n<h3><span id=\"2014\">-2014-<\/span><\/h3>\n<ol>\n<li>Bellelli, R., Castellone, M.D., Guida, T., Limongello, R., Dathan, N.A., Merolla, F., Cirafici, A.M., Affuso, A., Masai, H., Costanzo, V., Grieco, D., Fusco, A., Santoro, M., and *Carlomagno, F. (2014) &#8220;NCOA4 Transcriptional Coactivator Inhibits Activation of DNA Replication Origins.&#8221; <b>Mol. Cell\u00a0<\/b>55, 123-137.\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24910095\">[PubMed]<\/a><\/li>\n<li>\n<p align=\"left\">Yamada, M., <strong>Masai, H.<\/strong>, and *Bartek, J. (2014) &#8220;Regulation and roles of Cdc7 kinase under replication stress.&#8221;\u00a0<strong><em>Cell Cycle<\/em><\/strong> 13, 1859-1866.\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24841992\">[PubMed]<\/a><\/p>\n<\/li>\n<\/ol>\n<h3><span id=\"2013\">-2013-<\/span><\/h3>\n<ol>\n<li>\n<p align=\"left\">Yamada, M., Watanabe, K., Mistrik, M., Mailand, N., Lee, M-H., Masai, H., Lukas, J., and *Bartek, B. (2013) &#8220;ATR-Chk1-APC\/C<sup>Cdh1<\/sup>-dependent stabilization of Cdc7-ASK(Dbf4) kinase complex is required for DNA damage bypass under replication stress.&#8221;\u00a0<b>Genes and Development<\/b> 27:2459-2472.\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24240236\">[PubMed]<br \/>\n<\/a><\/p>\n<\/li>\n<li>\n<p align=\"left\">\u00a0You, Z., De Falco, S., Pisani, F.M. and *Masai, H. (2012) &#8220;MCM helicase interacts with primase and stimulates its priming activity.&#8221;\u00a0<b>PLoS One <\/b>8, e72408 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23977294\">[PubMed]<\/a><\/p>\n<\/li>\n<li>\n<p align=\"left\">\u00a0Aria, V., De Felice, M., Di Perna, R., Uno, S., Masai, H., Syvaoja, J.E., van Loon, B., Hubscher, U., and *Pisani, F.M. (2013) &#8220;The Human Tim\/Tipin Complex Directly Interacts with DNA Polymerase {epsilon} and Stimulates its Synthetic Activity.&#8221;<b>\u00a0J. Biol. Chem.<\/b> 288, 12742-12752. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23511638\">[PubMed]<\/a><\/p>\n<\/li>\n<li>\n<p align=\"left\">\u00a0Jeffery, D.C., Wyse, B.A., Rehman, M.A., Brown, G.W., You, Z., Oshidari, R., Masai, H., and *Yankulov, K.Y. (2013) &#8220;Analysis of epigenetic stability and conversions in Saccharomyces cerevisiae reveals a novel role of CAF-I in position-effect variegation.&#8221;<b>\u00a0Nucleic Acids Res.<\/b> 41, 8475-8488. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23863839\">[PubMed]<\/a><\/p>\n<\/li>\n<li>\n<p align=\"left\">\u00a0Tanikawa, M., Wada-Hiraike, O., Yoshizawa-Sugata, N., Shirane A, Hirano M, Hiraike H, Miyamoto, Y., Sone, K., Ikeda, Y., Kashiyama, T., Oda K, Kawana K, Katakura Y, Yano T, Masai, H., Roy AL, Osuga, Y., and *Fujii, T. (2013) &#8220;Role of multifunctional transcription factor TFII-I and putative tumour suppressor DBC1 in cell cycle and DNA double strand damage repair.&#8221;\u00a0<b>Br. J. Cancer<\/b><b>.<\/b> 109, 3042-3048. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24231951\">[PubMed]<\/a><\/p>\n<\/li>\n<\/ol>\n<h3><span id=\"2012\">-2012-<\/span><\/h3>\n<ol>\n<li>Hayano, M., Kanoh, Y., Matsumoto, S., Shrahige, K., and *Masai, H.\u00a0 (2012) &#8220;Rif1 is a global regulator of timing of replication origin firing in fission yeast.&#8221; <strong>Genes and Development<\/strong>, 26,137-150. (\u201cExceptional\u201d evaluation in F1000; Highlighted in A-IMBN Research)<\/li>\n<li>Yamazaki, S., Ishii, A., Kanoh, Y., Oda, M., Nishito, Y., and *Masai, H. (2012) &#8220;Rif1 protein is a key regulator of the genome-wide DNA replication timing in human cells.&#8221; <strong>EMBO J.<\/strong> 31, 3167-3177. (Highlighted in Commentary; highlighted in A-IMBN Research)<\/li>\n<li>Barkley, L.R., Palle, K., Durando, M., Day, T.A., Gurkar, A., Kakusho, N., Li, J., Masai, H., and\u00a0*Vaziri, C. (2012) &#8220;c-Jun N-terminal Kinase (JNK)-Mediated Rad18 Phosphorylation Facilitates Pol\u03b7 Recruitment to Stalled Replication Forks.&#8221; <strong>Mol. Biol. Cell.<\/strong> 23, 1943-1954.<\/li>\n<li>Moriyama, K., Yoshizawa-Sugata, N., Obuse, C., Tsurimoto, T., and *Masai, H.\u00a0 (2012) &#8220;EBNA1-dependent recruitment of Orc on OriP of Epstein-Barr virus with purified proteins: Stimulation by Cdc6 through Its direct interaction with EBNA1.&#8221; <strong>J. Biol. Chem.<\/strong> 287, 23977-23994.<\/li>\n<li>Ito, S., Ishii, A., Kakusho, N., Taniyama, C., Yamazaki, S., Sakaue-Sawano, A., Miyawaki, A., and *Masai, H. (2012) &#8220;Mechanism of cancer cell death induced by depletion of an essential replication regulator.&#8221; <strong>PLoS One<\/strong>, 7, e36372. (Highlighted in A-IMBN Research)<\/li>\n<li>Uno, S., You, Z., and *Masai, H. (2012) &#8220;Purification of replication factors using insect and mammalian cell expression systems.&#8221; Methods, 57, 214-221.<\/li>\n<li>Oda, M., Kanoh, Y., Watanabe, Y., and *Masai, H. (2012) &#8220;Regulation of DNA replication timing on human chromosome by a cell-type specific DNA binding protein SATB1.&#8221; <strong>PLoS One 7<\/strong>, e42375.<\/li>\n<li>Miyoshi, T., Kugou, K., Yamada, S., Ito, M., Furuichi, M., Oda, A., Hirota, K. and Masai, H. and *Ohta, K. (2012) &#8220;A central coupler for recombination initiation linking chromosome architecture to S-phase checkpoint.&#8221; <strong>Mol. Cell<\/strong> 47, 722-733.<\/li>\n<li>Suzuki, T., Tsuzuku, J., Hayashi, A., Shiomi, Y., Iwanari, H., Mochizuki, Y., Hamakubo, T., Kodama, T., Nishitani, H., Masai, H. and *Yamamoto, T. (2012) &#8220;Inhibition of DNA damage-induced apoptosis through Cdc7-mediated stabilization of Tob.&#8221; <strong>J. Biol. Chem.<\/strong>\u00a0287, 40256-40265. (Highlighted in A-IMBN Research)<\/li>\n<\/ol>\n<h3><span id=\"2011\">-2011-<\/span><\/h3>\n<ol>\n<li>Kitamura, R., Fukatsu, R., Kakusho, N., Cho, Y-S., Taniyama, C., Yamazaki, S., Toh, G-T., Yanagi, K., Arai, N., Chang, H-J., and *Masai, H. (2011) &#8220;Molecular mechanism of activation of human Cdc7 kinase: Bipartite interaction with Dbf4\/ASK stimulates ATP binding and substrate recognition.&#8221; <strong>J. Biol. Chem.<\/strong> 286, 23031-23043.<\/li>\n<li>Hayano, M., Kanoh, Y., Matsumoto, S., Kakusho, N. and *Masai, H. (2011) &#8220;Pre-firing binding of Mrc1 defines the early-firing origins which are selectively hyper-activated upon loss of fork stabilizing factors in fission yeast.&#8221; <strong>Mol. Cell. Biol.<\/strong> 31, 2380-2389. (\u201cRecommended\u201d evaluation in F1000)<\/li>\n<li>Uno, S and *Masai, H. (2011) &#8220;Efficient expression and purification of human replication fork-stabilizing factor, Claspin, from mammalian cells: DNA binding activity and novel protein interactions.&#8221; <strong>Genes to Cells<\/strong>, 16, 842-856.<\/li>\n<li>Matsumoto, S., Hayano, M., Kanoh. Y. and *Masai, H. (2011) &#8220;Multiple pathways can bypass the essential role of fission yeast Hsk1 kinase in DNA replication initiation.&#8221; <strong>J. Cell Biol.<\/strong> 195, 387-401. (\u201cMust Read\u201d evaluation in F1000)<\/li>\n<\/ol>\n<h3><span id=\"2010\">-2010-<\/span><\/h3>\n<ol style=\"list-style-type: upper-roman;\">\n<li>Tanaka, T., Yokoyama, M., Matsumoto, S., Fukatsu, R., You, Z. and *Masai, H. (2010) &#8220;Fission yeast Swi1-Swi3 complex facilitates DNA binding of Mrc1.&#8221;\u00a0<strong>J. Biol. Chem.<\/strong> 285, 39609-39622.<\/li>\n<li>Kundu,L.R., Kumata, Y, Kakusho, N., Watanabe, S., Furukohri, A., Waga, S., Sekia, M., Masai, H., Enomoto, T., and *Tada, S. (2010) &#8220;Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2-7 complex.&#8221; <strong>Nucleic Acid Res.<\/strong> 38, 5409-5418.<\/li>\n<li>Takeishi, Y., Ohashi, E., Ogawa, K, Masai, H., Obuse, C., and *Tsurimoto, T. (2010) &#8220;Casein kinase 2-dependent phosphorylation of human Rad9 mediates the interaction between human Rad9-Hus1-Rad1 complex and TopBP1.&#8221; <strong>Genes Cells<\/strong> 15, 761-771.<\/li>\n<li>Furuya, K., Miyabe, I., Tsutsui, Y., Paderi, F., Kakusho, N., Masai, H., Niki, H., and *Carr, A. M. (2010) &#8220;DDK phosphorylates checkpoint clamp Rad9 and promotes its release from damaged Chromatin.&#8221; <strong>Mol. Cell<\/strong> 40, 606-618.<\/li>\n<li>Day, T.A., Palle, K., Barkley, L.R., Kakusho, N., Zou, Y., Tateishi, S., Verreault, A., Masai, H., and *Vaziri, C. (2010) &#8220;Cdc7-Mediated Rad18 Phosphorylation Directs the Accumulation of DNA Polymerase \u03b7 at Sites of Stalled Replication.&#8221; <strong>J. Cell Biol.<\/strong> 191, 953-966.<\/li>\n<li>Matsumoto, S., Shimmoto, M., Kakusho, N., Yokoyama, M., Russell, P., and *Masai, H. (2010) &#8220;Hsk1 kinase and Cdc45 regulate replication stress-induced checkpoint responses in fission yeast.&#8221; <strong>Cell Cycle<\/strong> 9, 4627-4637.<\/li>\n<\/ol>\n<h3><span id=\"2009\">-2009-<\/span><\/h3>\n<ol>\n<li>Shimmoto, S., Matsumoto, S., Hayano, M., Yokoyama, M., Noguchi, E., Russell, P. and *Masai, H. (2009) &#8220;Interactions between Swi1-Swi3, Mrc1 and S phase kinase, Hsk1 may regulate cellular responses to stalled replication forks in fission yeast.&#8221; <strong>Genes to Cells<\/strong> 14, 669-682.<\/li>\n<li>Tanaka, H., Kubota, Y., Tsujimura, T., Kumano, M., Masai, H. and *Takisawa, H. (2009) &#8220;Replisome progression complex links DNA replication to sister chromatid cohesion in Xenopus egg extracts.&#8221; <strong>Genes to Cells<\/strong> 14, 949-963.<\/li>\n<li>Yoshizawa-Sugata, N. and *Masai, H. (2009) &#8220;Roles of human AND-1 in chromosome transactions in S phase.&#8221; <strong>J. Biol. Chem.<\/strong> 284, 20718-20728.<\/li>\n<\/ol>\n<h3><span id=\"2008\">-2008-<\/span><\/h3>\n<ol>\n<li>Kim, J-M., Kakusho, N., Yamada, M., Kanoh, Y., Takemoto, N., and *Masai, H. (2008) &#8220;Cdc7 kinase is required for Claspin phosphorylation in DNA replication checkpoint.&#8221; <strong>Oncogene<\/strong> 27, 3475-3482.<\/li>\n<li>Sasanuma, H., Hirota, K., Fukuda, T., Kakusho, N., Kugou, N., Kawasaki, Y., Shibata, T., Masai, H., and *Ohta, K. (2008) &#8220;Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination.&#8221; <strong>Genes &amp; Dev<\/strong>. 22, 398-410.<\/li>\n<li>Sakaue-Sawano, A., Kurokawa, H., Morimura, T., Hanyu, A., Hama, H., Kashiwagi, S., Fukami, K., Imamura, T., Ogawa, M., Masai, H. and *Miyawaki, A. (2008) &#8220;Spatio-temporal dynamics of multicellular cell cycle progression.&#8221; <strong>Cell<\/strong> 132, 487-498. (Featured on the cover of the issue; \u201cExceptional\u201d evaluation in F1000)<\/li>\n<li>Kakusho, N., Taniyama, C., and *Masai, H. (2008) &#8220;Identification of stimulators and inhibitors of CDC7 kinase in vitro.&#8221; <strong>J. Biol. Chem.<\/strong> 283, 19211-19218.<\/li>\n<li>You Z. and Masai H. (2008) &#8220;Cdt1 forms a complex with MCM and activates its helicase activity.&#8221; <strong>J. Biol. Chem.<\/strong> 283, 24469-24477.<\/li>\n<\/ol>\n<h3><span id=\"2007\">-2007-<\/span><\/h3>\n<ol>\n<li>Yoshizawa-Sugata, N. and *Masai, H. (2007) &#8220;Human Tim\/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint.&#8221; <strong>J. Biol. Chem.<\/strong> 282, 2729-2740<\/li>\n<li>Tanaka, T., Mizukoshi, T., Sasaki, K., Kohda, D. and Masai, H. (2007) &#8220;Escherichia coli PriA protein: Two modes of DNA binding and activation of ATP hydrolysis.&#8221; <strong>J. Biol. Chem.<\/strong> 282, 19917-19927.<\/li>\n<li>Sasaki, K., Ose, T., Okamoto, N., Maenaka, K., Tanaka, T., Masai, H., Saito, M., Shirai, T., and D. Kohda (2007) &#8220;Structural basis of the 3&#8242;-end recognition of a leading strand in stalled DNA replication forks by PriA. <strong>EMBO J.<\/strong> 26,19917-19927<\/li>\n<\/ol>\n<h3><span id=\"2006\">-2006-<\/span><\/h3>\n<ol>\n<li>Ogino, K. and Masai, H. (2006) &#8220;Rad3-Cds1 mediates coupling of initiation of meiotic recombination with DNA replication: Mei4-dependent transcription as a potential target of meiotic checkpoint.&#8221; <strong>J. Biol. Chem.<\/strong>, 281,1338-1344.<\/li>\n<li>Tanaka, T. and Masai, H. (2006) &#8220;Stabilization of a stalled replication fork by concerted actions of two helicases.&#8221; J. Biol. Chem. 281, 3484-3493.<\/li>\n<li>Sasaki, K., Ose, T., Tanaka, T., Mizukoshi, T., Ishigaki, T., Maenaka,K., Masai, H., and *Kohda, D. (2006) &#8220;Crystallization and preliminary crystallographic analysis of the N-terminal domain of PriA from Escherichia coli.&#8221; <strong>Biochim. Biophys. Acta.<\/strong>, 1764, 157-160.<\/li>\n<li>Kitamura, R., Sekimoto, T., Ito, S., Harada, S., Yamagata, H., Masai, H., Yoneda, H., and *Yanagi, K. (2006) &#8220;Nuclear import of Epstein-Barr Virus Nuclear Antigen 1 mediated by NPI-1 (Importin a5) is up- and down-regulated by phosphorylation of the nuclear localization signal for which Lys379 and Arg380 are essential.&#8221; <strong>J. Virol.<\/strong>, 80, 1979-1991.<\/li>\n<li>Ogino, K., Hirota, K., Matsumoto, S., Takeda, T., Ohta, K., Arai, K., and *Masai, H. (2006) &#8220;Hsk1 kinase is required for induction of meiotic double-stranded DNA breaks without involving checkpoint kinases in fission yeast.&#8221; <strong>Proc. Natl. Acad. Sci. USA<\/strong>, 103, 8131-8136.<\/li>\n<li>Hayashida, T., Oda , M., Ohsawa, K., Yamaguchi, A., Giacca, M., Locksley, R.M., Masai H.*, and Miyatake, S.* (2006) &#8220;Replication initiation from a novel origin identified in the Th2 cytokine cluster locus requires a distant conserved non-coding sequence.&#8221; (*cocommunicating authors) J. Immunol., 176, 5446-5454.<\/li>\n<li>*Masai, H., Taniyama, C., Ogino, K., Matsui, E., Kakusho, N., Matsumoto, M., Kim, J-M., Ishii, A., Tanaka, T., Kobayashi, T., Tamai, K., Ohtani, K., and Arai, K. (2006) &#8220;Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin.&#8221; <strong>J. Biol. Chem<\/strong>., 281, 39249-32961. (This paper was selected as \u201cJBC paper of the week\u201d and was featured in the cover of December 22 issue of JBC.)<\/li>\n<\/ol>\n<h3><span id=\"2005\">-2005-<\/span><\/h3>\n<ol>\n<li>Fujii-Yamamoto, H., Kim, J-M., Arai, K. and *Masai, H. (2005) &#8220;Cell cycle and developmental regulations of replication factors in mouse embryonic stem cells.&#8221;<strong> J. Biol. Chem.<\/strong> 280, 12976-12987.<\/li>\n<li>Yoshizawa-Sugata, N., Ishii, A., Taniyama, C., Matsui, E., Arai, K., and *Masai, H. (2005) &#8220;A second human Dbf4\/ASK-related protein, Drf1\/ASKL1 is required for efficient completion of S and M phases.&#8221; <strong>J. Biol. Chem.<\/strong> 280, 13062-13070.<\/li>\n<li>Yamashita, N., Kim, J-M., Koiwai, O., Arai, K. and *Masai, H. (2005) &#8220;Functional analyses of mouse ASK, an activator subunit for Cdc7 kinase, using conditional ASK knockout ES cells.&#8221; <strong>Genes to Cells<\/strong> 50, 551-563.<\/li>\n<li>You, Z. and *Masai, H. (2005) &#8220;DNA binding and helicase actions of mouse Mcm4\/6\/7 helicase.&#8221; <strong>Nucl. Acids Res.<\/strong> 33, 3033-3047.<\/li>\n<li>Todorovic, V., Giadrossi, S., Pelizon, C., Masai, H. and *Giacca, M. (2005) &#8220;Novel human origins of DNA replication selected from a library of nascent DNA.&#8221; <strong>Mol. Cell<\/strong> 19, 567-575.<\/li>\n<li>Matsumoto, S., Ogino, K., Noguchi, E., Russell, P. and *Masai, H. (2005)\u00a0 &#8220;Hsk1-Dfp1\/Him1, the Cdc7-Dbf4 Kinase in Schizosaccharomyces pombe, associates with Swi1, a component of the replication fork protection complex.&#8221; <strong>J. Biol. Chem.<\/strong>, 280, 42536-42542.<\/li>\n<\/ol>\n<h3><span id=\"2004\">-2004-<\/span><\/h3>\n<ol>\n<li>Schnepp, R.W., Hou, Z., Wang, H., Petersen, C., Silva, A, Masai, H. and *Hua X. (2004) &#8220;Functional interaction between tumor suppressor menin and activator of S-phase kinase.&#8221; <strong>Cancer Res.<\/strong> 64, 6791-6796.<\/li>\n<li>Kurita, M., Suzuki, H., Masai, H., Mizumoto, K., Ogata, E., Nishimoto, I., Aiso, S., and *Matsuoka, M. (2004) &#8220;Overexpression of CR\/periphilin downregulates Cdc7 expression and induces S-phase arrest.&#8221; <strong>Biochem. Biophys. Res. Commun<\/strong>. 32, 554-561.<\/li>\n<\/ol>\n<h3><span id=\"2003\">-2003-<\/span><\/h3>\n<ol>\n<li>Tanaka, T., Taniyama, C., Arai, K., and *Masai, H. (2003) &#8220;ATPase\/helicase motif mutants of Escherichia coli PriA protein essential for recombination-dependent DNA replication.&#8221; <strong>Genes to Cells<\/strong>, 8, 251-261.<\/li>\n<li>Sato, N., Sato, M., Nakayama, M., Saitoh, R., Arai, K., and *Masai, H. (2003) &#8220;Cell cycle regulation of chromatin binding and nuclear localization of Cdc7-ASK kinase complex.&#8221; <strong>Genes to Cells<\/strong>, 8, 451-463.<\/li>\n<li>Kim, J.M., Takemoto, N., Arai K. and *Masai, H. (2003) &#8220;Hypomorphic mutation in an essential cell-cycle kinase causes growth retardation and impaired spermatogenesis.&#8221; <strong>EMBO J.<\/strong> 22, 5260-5272.<\/li>\n<li>Mizukoshi, T., Tanaka, T., Arai, K., Kohda, D. and *Masai, H. (2003)\u00a0 &#8220;A critical role of the 3\u2019-terminus of nascent DNA chains in recognition of stalled replication forks.&#8221; <strong>J. Biol. Chem.<\/strong> 278, 42234-42239.<\/li>\n<li>You, Z., Ishimi, Y., Mizuno, T., Sugasawa, K., Hanaoka, F. and *Masai, H. (2003) &#8220;Thymine-rich single-stranded DNA sequences specifically activate mouse Mcm4\/6\/7 helicase on Y-fork and bubble-like substrates.&#8221; <strong>EMBO J.<\/strong> 22, 6148-6160.<\/li>\n<li>Furukohri, A., Sato, N., Masai, H., Arai, K., Sugino, A. and *Waga, S. (2003) &#8220;Identification and characterization of a Xenopus homolog of dbf4, a regulatory subunit of the cdc7 protein kinase required for the initiation of DNA.&#8221; <strong>J. Biochem.<\/strong>\u00a0(Tokyo). 134, 447-457.<\/li>\n<\/ol>\n<h3><span id=\"2002\">-2002-<\/span><\/h3>\n<ol>\n<li>Kim, J. M., Nakao, K., Nakamura, K., Saito, I., Katsuki, M., Arai, K., and *Masai, H. (2002) &#8220;Inactivation of Cdc7 kinase in mouse embryonic stem cells results in S phase arrest and p53-dependent cell death.&#8221; <strong>EMBO J.<\/strong> 21, 2168-2179. (\u201cExceptional\u201d evaluation in F1000)<\/li>\n<li>Yamada, M., Sato, N., Taniyama, C., Ohtani, K., Arai, K., and *Masai, H. (2002) &#8220;A 63 base-pair DNA segment containing a Sp1 site but not a canonical E2F site can confer growth-dependent and E2F-mediated transcriptional stimulation of the human ASK gene encoding the regulatory subunit for human Cdc7-related kinase.&#8221; <strong>J. Biol. Chem.<\/strong> 277, 27668-27681.<\/li>\n<li>Tanaka, T., Mizukoshi, T., Taniyama, C., Kohda, D., Arai, K., and *Masai, H. (2002) &#8220;DNA binding of PriA protein requires cooperation of the N-terminal D-loop\/arrested-fork binding and C-terminal helicase domains.&#8221; <strong>J. Biol. Chem.<\/strong> 277, 38062-38071.<\/li>\n<li>*You, Z.,\u00a0 Ishimi, Y., Masai, H., and Hanaoka, F. (2002) &#8220;Roles of Mcm7 and Mcm4 subunits in DNA helicase activity of mouse Mcm4\/6\/7 complex.&#8221; <strong>J. Biol. Chem.<\/strong> 277, 42471-42479.<\/li>\n<\/ol>\n<h3><span id=\"2001\">-2001-<\/span><\/h3>\n<ol>\n<li>Takeda, T., Ogino, K., Tatebayashi, K. Ikeda, H., Arai, K., and *Masai, H. (2001) &#8220;Regulation of initiation of DNA replication and maintenance of mitotic chromosome structures during S phase by Hsk1 kinase in the fission yeast.&#8221; <strong>Mol. Biol. Cell<\/strong> 12, 1257-1274.<\/li>\n<li>Uchiyama, M., Griffiths, D., Arai, K., and *Masai, H. (2001) &#8220;Essential role of Cdc45 in the loading of DNA polymerase a into MCM in fission yeast.&#8221;\u00a0 J. Biol. Chem. 276, 26189-26196.<\/li>\n<li>Uchiyama, M., Arai, K., and Masai, H. (2001) &#8220;A novel fission yeast G1 arrest mutant sna41goa1 defective in a Cdc45 homologue interacts genetically with DNA polymerase a.&#8221; <strong>Mol. Genet. Genom.<\/strong> 265, 1039-1049.<\/li>\n<li>Ogino, K., Takeda, T., Matsui, E., Iiyama, H., Taniyama, C., Arai, K., and *Masai, H. (2001) &#8220;Bipartite binding of a kinase activator activates Cdc7-related kinase essential for S phase.&#8221; <strong>J. Biol. Chem.<\/strong> 276, 31376-31387.<\/li>\n<li>*Ishimi, Y., Komamura-Kohno, Y., Arai, K. and Masai, H. (2001) &#8220;Biochemical activities associated with mouse Mcm2 protein.&#8221; <strong>J. Biol. Chem.<\/strong> 276, 42744-42752.<\/li>\n<\/ol>\n<h3><span id=\"2000\">-2000-<\/span><\/h3>\n<ol>\n<li>*Masai, H., Matsui, E., You, Z., Ishimi, Y., Tamai, K., and Arai, K. (2000) &#8220;Human Cdc7-related kinase complex: In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a critical threonine residue of Cdc7 by Cdks.&#8221;<strong> J. Biol. Chem.<\/strong> 275, 29042-29052.<\/li>\n<li>*Masai, H. and Arai, K. (2000) &#8220;Dbf4 motifs: conserved motifs in activation subunits for Cdc7 kinases essential for S-phase.&#8221; <strong>Biochem. Biophys. Res. Commun.<\/strong> 18, 228-232.<\/li>\n<\/ol>\n<h3><span id=\"1999\">-1999\u4ee5\u524d\u306e\u4e00\u90e8-<\/span><\/h3>\n<ol>\n<li><strong>Masai, H.<\/strong>, Kaziro, Y., and *Arai, K. (1983) &#8220;Definition of <i>oriR<\/i>, the minimum DNA segment essential for initiation of R1 plasmid replication <i>in vitro<\/i>.&#8221;\u00a0<b>Proc. Natl. Acad. Sci. USA<\/b> 80, 6814-6818.<\/li>\n<li><strong>Masai, H.<\/strong>, Bond, M.W., and *Arai, K. (1986) &#8220;Cloning of the <i>Escherichia coli<\/i> gene for primosomal protein i: the relationship to <i>dnaT<\/i>, essential for chromosomal DNA replication.&#8221;\u00a0<b>Proc. Natl. Acad. Sci. USA<\/b> 83, 1256-1260.<\/li>\n<li><strong>Masai, H.<\/strong> and *Arai, K. (1987) &#8220;RepA and DnaA proteins are required for initiation of R1 plasmid replication <i>in vitro<\/i> and interact with the <i>oriR<\/i> sequence.&#8221;\u00a0<b>Proc. Natl. Acad. Sci. USA<\/b> 84, 4781-4785.<\/li>\n<li><strong>*Masai, H.<\/strong>, and Arai, K. (1988) &#8220;RepA protein- and <i>oriR<\/i>&#8211; dependent initiation of R1 plasmid replication: identification of a rho-dependent transcription terminator required for <i>cis<\/i>-action of repA protein.&#8221;\u00a0<b>Nucleic Acids Res. <\/b>16, 6493-6514.<\/li>\n<li><strong>*Masai, H.<\/strong> and Arai, K. (1989) &#8220;Leading strand synthesis of R1 plasmid replication <i>in vitro<\/i> is primed by primase alone at a specific site downstream of <i>oriR<\/i>.&#8221;\u00a0<b>J. Biol. Chem. <\/b>264, 8082-8090.<\/li>\n<li><strong>*Masai, H.<\/strong>, Nomura, N. and Arai, K. (1990) &#8220;The ABC-primosome: a novel priming system employing dnaA, dnaB, dnaC, and primase on a hairpin containing a dnaA box sequence.&#8221;\u00a0<b>J. Biol. Chem.<\/b> 265, 15134-15144.<\/li>\n<li><strong>*Masai, H.<\/strong>, Asai, T., Kubota, Y., Arai, K. and Kogoma, T. (1994) &#8220;<i>Escherichia coli<\/i> PriA protein is essential for inducible and constitutive stable DNA replications.&#8221;\u00a0<b>EMBO J.<\/b> 13, 5338-5345.<\/li>\n<li><strong>*Masai, H.<\/strong>, Miyake, T. and Arai, K. (1995) &#8220;<i>hsk1<\/i><sup>+<\/sup>, a <i>Schizosaccharomyces pombe<\/i> gene related to <i>Saccharomyces cerevisiae<\/i> CDC7 kinase, is required for chromosomal replication.&#8221;\u00a0<b>EMBO J.<\/b> 14 3094-3104.<\/li>\n<li>\u00a0Sato, N., Arai, K. and <strong>*<\/strong><strong>Masai, H.<\/strong> (1997) &#8220;Human and <i>Xenopus<\/i> cDNAs encoding budding yeast Cdc7-related kinases: <i>in vitro<\/i> phosphorylation of MCM subunits by a putative human homologue of Cdc7.&#8221;\u00a0<b>EMBO J.<\/b> 16, 4340-4351.<\/li>\n<li><strong>*Masai, H.<\/strong> and Arai, K. (1997) &#8220;F<i>rpo<\/i>, a novel single-stranded DNA promoter for transcription and for primer RNA synthesis of DNA replication.&#8221;\u00a0\u00a0<b>Cell<\/b> 89, 897-907.<\/li>\n<li>Kumagai, H., Sato, N., Yamada, M., Mahony, D., Seghezzi, W., Lees, E., Arai, K., and *<b>Masai, H.<\/b> (1999) &#8220;A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1\/S transition in mammalian cells.&#8221;<b>\u00a0Mol. Cell. Biol.<\/b> 19, 5083-5095.<\/li>\n<li>\u00a0Takeda, T., Ogino, K., Matsui, E., Cho, M-K., Kumagai, H., Miyake, T., Arai, K., and *<b>Masai, H.<\/b> (1999) &#8220;A Fission yeast gene, <i>him1<\/i><sup>+<\/sup>\/<i>dfp1<\/i><sup>+<\/sup>, encoding a regulatory subunit for Hsk1 kinase, plays essential roles in S phase initiation as well as in S phase checkpoint control and recovery from DNA damages.&#8221;\u00a0<b>Mol. Cell. Biol.<\/b> 19, 5535-5547.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<h2><span id=\"Reviews-and-Book-chapters-in-English-only-To-view-crick-here-first\">Reviews and Book chapters (in English only) To view crick here first!<\/span><\/h2>\n<h3><span id=\"\"><\/span><\/h3>\n<h3><span id=\"2025\">-2025-<\/span><\/h3>\n<h3><span id=\"2024\">-2024-<\/span><\/h3>\n<ol>\n<li><span lang=\"EN-US\">*Zhiying You and <b>Hisao Masai <\/b><\/span><span lang=\"EN-US\" style=\"font-size: 14.08px;\">&#8220;<\/span><span lang=\"EN-US\" style=\"font-size: 14.08px;\">Assembly Activation and Helicase Actions of MCM2-7: Transi<\/span><span lang=\"EN-US\" style=\"font-size: 14.08px;\">tion from Inactive MCM2-7 Double Hexamers to Active Replication Forks.<\/span><span lang=\"EN-US\" style=\"font-size: 14.08px;\">&#8221; <b><i>Biology<\/i><\/b> <\/span><span lang=\"EN-US\" style=\"font-size: 14.08px;\"><span lang=\"EN-US\" style=\"font-size: 14.08px;\">13:629<\/span><\/span><span style=\"font-size: 14.08px;\">. doi: 10.3390\/biology13080629.<\/span><\/li>\n<\/ol>\n<h3><span id=\"2023\">-2023-<\/span><\/h3>\n<h3><span id=\"2022\">-2022-<\/span><\/h3>\n<ol>\n<li><strong>Masai, H.<\/strong> (2022) &#8220;TT-pocket\/HIRAN: binding to 3\u2019-terminus of DNA for recognition and processing of stalled replication forks.&#8221; <strong><em>J. Biochem.<\/em><\/strong> 172(2):57-60. doi: 10.1093\/jb\/mvac042.<\/li>\n<li>Masai, H. (2022) &#8220;Replicon hypothesis revisited&#8221; <strong><em>Biochemical and Biophysical Research Communications <\/em><\/strong><span style=\"font-size: 14.08px;\">633:77-80. doi: 10.1016\/j.bbrc.2022.09.060.<\/span><\/li>\n<\/ol>\n<h3><span id=\"2021\">-2021-<\/span><\/h3>\n<ol>\n<li><span lang=\"EN-US\">Oki M, <\/span><span lang=\"EN-US\">*<\/span><b><span lang=\"EN-US\">Masai H.<\/span><\/b><span lang=\"EN-US\"><span lang=\"EN-US\"> (2021) &#8220;Regulation of HP1 protein by phosphorylation during transcriptional repression and cell cycle.&#8221;\u00a0<b><i>J. Biochem.<\/i><\/b><\/span><\/span><span style=\"font-size: 14.08px;\">169(6):629-632. doi: 10.1093\/jb\/mvab040. PMID: 33772590<\/span><\/li>\n<li>Hsiao H-W, Yang C-C, *<strong>Masai H<\/strong> (2021) Roles of Claspin in regulation of DNA replication, replication stress responses and oncogenesis in human cells. <em>Genome <strong>Instability &amp; Disease<\/strong><\/em> 2: 263\u2013280. doi.org\/10.1007\/s42764-021-00049-8<\/li>\n<\/ol>\n<h3><span id=\"2020\">-2020-<\/span><\/h3>\n<ol>\n<li><b><span lang=\"EN-US\"><strong>*<\/strong>Masai, H.<\/span><\/b><span lang=\"EN-US\"> and Tan, Z. (2020) \u201cG-quadruplexes: tools, roles, and goals.\u201d <\/span><b><i><span lang=\"EN-US\">Biochemical and Biophysical Research Communications<\/span><\/i><\/b><span lang=\"EN-US\">, <\/span><span lang=\"EN-US\">531:1-2.<\/span><\/li>\n<li><b><span lang=\"EN-US\"><strong>*<\/strong>Masai, H.<\/span><\/b><span lang=\"EN-US\"> and Tanaka, T. (2020) \u201cG-quadruplex DNA and RNA: Their roles in regulation of DNA replication and other biological functions.\u201d <\/span><b><i><span lang=\"EN-US\">Biochemical and Biophysical Research Communications<\/span><\/i><\/b><span lang=\"EN-US\">, <\/span><span lang=\"EN-US\">531:25-38.<\/span><\/li>\n<li>Alavi, S., Ghadiri, H., Dabirmanesh, B., Moriyama, K., Khajeh, K., and *<strong>Masai, H.<\/strong> (2020) G-quadruplex binding protein Rif1, a key regulator of replication timing.\u00a0<strong style=\"font-size: 14.079999923706055px;\"><em>J. Biochem.<\/em><\/strong><span style=\"font-size: 14.079999923706055px;\"> doi: 10.1093\/jb\/mvaa128. Epub ahead of print. PMID: 33169133<\/span><\/li>\n<\/ol>\n<h3><span id=\"2019\">-2019-<\/span><\/h3>\n<ol>\n<li>Tanaka, T. and *<strong>Masai, H.<\/strong> (2019) &#8220;Bacterial primosome.&#8221; In: Encyclopedia of Life Sciences (ELS). John Wiley &amp; Sons, Ltd: Chichester.<\/li>\n<li><strong>Masai, H.<\/strong> (2019) \u201cFor 60th birthday of BBRC: DNA replication factors outside S phase.\u201d<strong><em> Biochemical and Biophysical Research Communications<\/em><\/strong>,\u00a0520:685-686.<\/li>\n<\/ol>\n<h3><span id=\"2018\">-2018-<\/span><\/h3>\n<ol>\n<li><strong>*Masai H<\/strong>, Kanoh Y, Moriyama K, Yamazaki S, Yoshizawa N, Matsumoto S. Telomere-binding factors in the regulation of DNA replication. <em><strong>Genes Genet Syst.<\/strong><\/em>\u00a092, 119-125. (Review)<\/li>\n<li>Ghadiri, H. Alavi, S., Dabirmanesh, B., Moriyama, K., <strong>*<\/strong>Khajeh, K. and <strong>Masai, H.<\/strong> &#8220;Study Break: Cell Timer\/Cell Clock.&#8221; <strong><em>Iran Biomed J<\/em><\/strong>. 2018 Sep 16. [Epub ahead of print] PubMed PMID: 30218996.<\/li>\n<\/ol>\n<h3><span id=\"2017\">-2017-<\/span><\/h3>\n<ol style=\"list-style-type: upper-roman;\">\n<li>Moriyama K, Lai MS, and\u00a0<strong>*Masai H\u00a0<\/strong>(2017)\u00a0Interaction of Rif1 Protein with G-Quadruplex in\u00a0Control of Chromosome Transactions. <em><strong>Adv Exp Med Biol.<\/strong><\/em> 1042, 287-310. doi:10.1007\/978-981-10-6955-0_14. PubMed PMID: 29357064.<\/li>\n<li><strong>*Masai H<\/strong>, Yang CC, and Matsumoto S. (2017) Mrc1\/Claspin: a new role for regulation of\u00a0origin firing. <em><strong>Curr Genet.<\/strong> <\/em>2017 Oct;63(5):813-818. doi:10.1007\/s00294-017-0690-y. Epub 2017 Mar 29. Review. PubMed PMID: 28357499. (Review)<\/li>\n<li><strong>*Masai H.<\/strong> (2017) A novel p53-Cdc7 link induced by genotoxic stress. \u00a0<em><strong>Cell Cycle\u00a0<\/strong><\/em>16, 735-736. doi: 10.1080\/15384101.2017.1304746. Epub 2017 Mar 15.\u00a0PubMed PMID: 28296554; PubMed Central PMCID: PMC5405723. (Commentary)<\/li>\n<li>*<strong>Masai, H.<\/strong> (2017) &#8220;A novel p53-Cdc7 link induced by genotoix stress.&#8221; <strong><em>Cell Cycle<\/em><\/strong>, in press (News and Views)<\/li>\n<li>*<strong>Masai, H. <\/strong>Encyclopedia of Signaling Molecules, 2nd Edition : Dbf4 (2017) in press<\/li>\n<li>*<strong>Masai, H. <\/strong>Encyclopedia of Signaling Molecules, 2nd Edition : Cdc7 (2017) in press<\/li>\n<\/ol>\n<h3><span id=\"2016\">-2016-<\/span><\/h3>\n<h3><span id=\"2015\">-2015-<\/span><\/h3>\n<ol>\n<li><strong>*Masai, H.<\/strong> (2015) &#8220;Building up the machinery for DNA replication.&#8221;\u00a0<strong><em>Cell Cycle<\/em><\/strong> 14, 3011-3012. (News and Views)<\/li>\n<li>Yoshizawa, N., Yamazaki, S., and *<strong>Masai, H.<\/strong> (2015) &#8220;Rif1, a conserved chromatin factor regulating DNA replication, DNA repair and transcription.&#8221; In <em>The Initiation of DNA Replication in Eukaryotes<\/em>, Springer<\/li>\n<li>Hayano, M., Matsumoto, S. and <strong>*Masai, H<\/strong>. (2015) &#8220;DNA Replication Timing: Temporal and Spatial Regulation of Eukaryotic DNA Replication.&#8221; in Fumio\u00a0Hanaoka and Kaoru Sugasawa (Eds): DNA Replication, Recombination, and Repair (Springer)<\/li>\n<li>Naoko Yoshizawa, Satoshi Yamazaki, and <strong>*Hisao Masai<\/strong>\u00a0(2015) &#8220;Rif1, a conserved chromatin factor regulating DNA replication, DNA repair and transcription.&#8221; In <em>The Initiation of DNA Replication in Eukaryotes<\/em>, Springer, in press.<\/li>\n<li><strong>*Masai H.<\/strong> (2015) Building up the machinery for DNA replication. <strong>Cell Cycle<\/strong>. [Epub ahead of print] PubMed PMID: 26315494. (Commentary) <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26315494\">[PubMed]<\/a><\/li>\n<li><\/li>\n<\/ol>\n<h3><span id=\"2014\">-2014-<\/span><\/h3>\n<ol>\n<li><strong>*Hisao Masai<\/strong> (2014) News and Views &#8220;ATM in prevention of genomic instability.&#8221;\u00a0<b>Cell Cycle<\/b>, 13, 882-883.\u00a0(Commentary)\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24552814\">[PubMed]<\/a><\/li>\n<li>Claire Renard-Guillet, Yutaka Kanoh, Katsuhiko Shirahige, and <strong>*Hisao Masai<\/strong> (2014) &#8220;Recent advances in temporal and spatial regulation of eukaryotic DNA replication: From regulated initiation to genome-scale timing program.&#8221;\u00a0<b>Seminars in Cell &amp; Developmental Biology<\/b>, 30C, 110-120.\u00a0(Review)\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24727367\">[PubMed]<\/a><\/li>\n<li>Yoshizawa-Sugata, N. and *Masai, H. (2014) &#8220;Cell cycle synchronization and flow cytometry analysis of mammalian cell.&#8221;\u00a0<b>Methods in Molecular Biology<\/b>, 1170, 279-293.\u00a0(Review)\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24906318\">[PubMed]<\/a><\/li>\n<\/ol>\n<h3><span id=\"2013\">-2013-<\/span><\/h3>\n<ol>\n<li>Yamazaki, Hayano, M., and <strong>*Masai, H.<\/strong> (2013) &#8220;Replication timing regulation of eukaryotic replicons: Rif1 as a global regulator of replication timing.&#8221;\u00a0<b>Trends in Genetics.<\/b>\u00a029, 449-460. (Review) <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23809990\">[PubMed]<\/a><\/li>\n<li><strong>*Masai, H.<\/strong> (2013) &#8220;A personal reflection on the Replicon Theory: from R1 plasmid to replication timing regulation in human cells.&#8221;\u00a0<b>J.\u00a0<\/b><b>Mol. Biol.<\/b>\u00a0425, 4663-4672. (Review) <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23579064\">[PubMed]<\/a>\u00a0<a href=\"https:\/\/www.igakuken.or.jp\/genome\/wp-content\/uploads\/2014\/03\/YJMBI64036.pdf\">[See also here]<\/a><\/li>\n<li>Matsumoto, S. and <strong>*Masai, H.<\/strong> (2013) &#8220;Regulation of chromosome dynamics by Hsk1 kinase.&#8221;\u00a0<b>B<\/b><b>iochemical Society Transactions<\/b>\u00a041, 1712-1719. (Review) <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24256280\">[PubMed]<\/a><\/li>\n<\/ol>\n<h3><span id=\"2012\">-2012-<\/span><\/h3>\n<ol>\n<li>\u00a0Toh G-T. and *Masai, H. (2012) &#8220;Cdc7L1&#8221;\u00a0<b>UCSD-Nature Molecule Pages<\/b>, Published online: 31 August 2012 | doi:10.6072\/H0.MP.A003137.01 (Review)<\/li>\n<li>*Masai, H. (2012) &#8220;Cdc7&#8221; The Encyclopedia of Signaling Molecules Springer\u2028Reference and Database Publishing\u00a0(Review)<\/li>\n<li>*Masai, H. (2012) &#8220;Dbf4&#8221; The Encyclopedia of Signaling Molecules Springer\u2028 Reference and Database Publishing\u00a0(Review)<\/li>\n<\/ol>\n<h3><span id=\"2011\">-2011-<\/span><\/h3>\n<ol>\n<li>*Masai, H. (2011) &#8220;RecQL4: a helicase linking formation and maintenance of a replication fork.&#8221;\u00a0<b>J. Biochem.<\/b>\u00a0149, 629-631 (commentary)<\/li>\n<\/ol>\n<h3><span id=\"2010\">-2010-<\/span><\/h3>\n<ol>\n<li>*Masai, H., Matsumoto, S., You, Z., Yoshizawa-Sugata, N., and Oda, M. (2010) Eukaryotic DNA replication; where, when and how? <strong>Annual Rev. Biochem.<\/strong> 79, 89-130.\u00a0(Review)<\/li>\n<li>*Masai, H., Tanaka, T., and Kohda, D. (2010) &#8220;Stalled replication forks: Making ends meet for recognition and stabilization.&#8221; <strong>Bioessays<\/strong> 32, 687-697. (Review)<\/li>\n<li>Tanaka, T. and *Masai, H. (2010) &#8220;Bacterial primosome.&#8221; In: Encyclopedia of Life Sciences (ELS). John Wiley &amp; Sons, Ltd: Chichester. DOI: 10.1002\/9780470015902.a0001048.pub2\u00a0(Review)<\/li>\n<li>Tanaka, T. and *Masai, H. (2010) &#8220;Bacterial replication fork: synthesis of lagging strand.&#8221; In: Encyclopedia of Life Sciences (ELS). John Wiley &amp; Sons, Ltd: Chichester. DOI: 10.1002\/9780470015902.a0001049.pub2\u00a0(Review)<\/li>\n<li>*Masai, H. (2010) &#8220;FANCs regulate firing of DNA replication origins.&#8221; <strong>Cell Cycle<\/strong> 9, 2494. (Commentary)<\/li>\n<li>Vaziri, C. and *Masai, H. (2010) &#8220;Integrating DNA replication with Trans-Lesion Synthesis via Cdc7.&#8221; <strong>Cell Cycle<\/strong> 9, 4818-4823.\u00a0(Review)<\/li>\n<\/ol>\n<h3><span id=\"2009\">-2009-<\/span><\/h3>\n<ol>\n<li>Sawa, M., and *Masai, H. (2009) &#8220;Drug Design with Cdc7 kinase, a potential novel cancer therapy target.&#8221; <strong>Drug Design, Development and Therapy<\/strong> 2, 255-264.\u00a0(Review)<\/li>\n<li>Toh, G.K., and *Masai, H. (2009) &#8220;ASK&#8221; UCSD-Nature Molecule Pages, Published online: 25 Feb 2009 | doi:10.1038\/mp.a000345.01 (Review)<\/li>\n<\/ol>\n<h3><span id=\"2008\">-2008-<\/span><\/h3>\n<ol>\n<li>Fujii-Yamamoto, H., Yamada. M., and *Masai, H. (2008) &#8220;Regulation of DNA replication factors by E2F in cancer and embryonic stem cells.&#8221; in &#8220;Control of Cellular Physiology by E2F Transcription Factors&#8221; <strong>Research Signpost<\/strong> 209-221.(Review)<\/li>\n<li>Ito, S., Taniyama, C., Arai, N. and *Masai, H. (2008) &#8220;Cdc7 as a potential new target for cancer therapy.&#8221; <strong>Drug News and Perspectives<\/strong> 21, 481-488. (Review)\u00a0Featured on the cover of the issue<\/li>\n<\/ol>\n<h3><span id=\"2005\">-2005-<\/span><\/h3>\n<ol>\n<li>*Masai, H., Zhiying, Y. &amp; Arai, K. (2005) &#8220;Control of DMA replication: regulation and activation of the eukaryotic replicative helicase, MCM.&#8221; <strong>IUBMB Life<\/strong> 57, 323-335.\u00a0(Review)<\/li>\n<\/ol>\n<h3><span id=\"2004\">-2004-<\/span><\/h3>\n<ol>\n<li>Kim, J-M. and *Masai, H. (2004) &#8220;Genetic dissection of mammalian Cdc7 kinase: Cell cycle and developmental roles.&#8221; <strong>Cell Cycle<\/strong> 3, 300-304.\u00a0(Review)<\/li>\n<\/ol>\n<h3><span id=\"2003\">-2003-<\/span><\/h3>\n<ol>\n<li>Kim, J-M., Yamada, M. and *Masai, H. (2003) Review: &#8220;Defect in Cdc7 kinase leads to checkpoint responses and p53-dependent cell death in mammalian cells.&#8221; <strong>Mutation Research<\/strong> 532, 29-40.<\/li>\n<\/ol>\n<h3><span id=\"2002\">-2002-<\/span><\/h3>\n<ol>\n<li>*Masai, H. and Arai, K. (2002) Review with a cover photo: &#8220;Cdc7 kinase complex: A key regulator for initiation of DNA replication.&#8221; <strong>J. Cell. Physiol.<\/strong>\u00a0190, 287-296.\u00a0(Review)<\/li>\n<\/ol>\n<h3><span id=\"2001\">-2001-<\/span><\/h3>\n<ol>\n<li>*Masai, H. (2001) Bacterial replication fork: synthesis of lagging strand, Encyclopedia of Life Sciences (Macmilan Reference Limited)\u00a0(Review)<\/li>\n<li>*Masai, H. (2001) Bacterial primosome, Encyclopedia of Life Sciences (Macmilan Reference Limited)\u00a0(Review)<\/li>\n<\/ol>\n<h3><span id=\"2000\">-2000-<\/span><\/h3>\n<ol>\n<li>*Johnstone, L., Masai, H. and Sugino, A. (2000) Review: &#8220;A Cdc7p-Dbf4p protein kinase activity is conserved from yeast to humans.&#8221; <strong>Prog. Cell Cycle Res.<\/strong> 4, 61-69.<\/li>\n<li>*Masai, H. and Arai, K. (2000) Review: &#8220;Regulation of DNA replication during cell cycle: Roles of Cdc7 kinase and coupling of replication, recombination, and repair in response to replication fork arrest.&#8221; <strong>IUBMB Life<\/strong> 49, 353-364.<\/li>\n<\/ol>\n<h3><span id=\"1999\">-1999-<\/span><\/h3>\n<ol>\n<li>*Johnstone, L., Masai, H. and Sugino, A. (1999) Review: &#8220;First the Cdk&#8217;s, now the Ddk&#8217;s.&#8221; <strong>Trends in Cell Biology<\/strong> 9, 249-252<\/li>\n<li>*Masai, H., Sato, N., Takeda, T. and Arai, K. (1999) Review: &#8220;Cdc7\/Dbf4-related kinase complex as a molecular switch for initiation of DNA replication.&#8221; <strong>Frontiers in Bioscience<\/strong> 4, 834-840.<\/li>\n<\/ol>\n<h3><span id=\"1996\">-1996-<\/span><\/h3>\n<ol>\n<li>*Masai, H. and Arai, K. (1996) Review: &#8220;DnaA- and PriA-dependent primosomes: two distinct replication complexes for replication of Escherichia coli chromosome.&#8221; <strong>Frontiers in Bioscience<\/strong> 1, 49-59.<\/li>\n<li>*Masai, H. and Arai, K. (1996) &#8220;Mechanisms of primer RNA synthesis and D-loop\/R-loop-dependent DNA replication of Escherichia coli.&#8221; <strong>Biochimie<\/strong> 78, 1109-1117.\u00a0(Review)<\/li>\n<\/ol>\n<h3><span id=\"1994\">-1994-<\/span><\/h3>\n<ol>\n<li>*Masai, H. and Arai, K. (1994) Review: &#8220;Replication and transcription on single-stranded DNA templates: proteins that specifically recognize single-stranded DNA sequences with a higher order structure.&#8221; <strong>Mol. Biol. (Life Sci. Adv.)<\/strong> 13, 19-37.<\/li>\n<\/ol>\n<h3><span id=\"1988\">-1988-<\/span><\/h3>\n<ol>\n<li>Masai, H. and *Arai, K. (1988) Book chapter: &#8220;R1 plasmid replication in vitro: repA- and dnaA-dependent initiation at oriR&#8221; in DNA Replication and Mutagenesis Edited by R. E. Moses and W. C. Summers, American Society for Microbiology, Washington, pp 113-121.\u00a0(Review)<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"ContentsOriginal Papers (2000 &#8211; 2025)-2025&#8211;2024&#8211;2023&#8211;2022&#8211;202<a href=\"https:\/\/www.igakuken.or.jp\/genome\/?page_id=119\">&nbsp;&nbsp;[&#8230;\u7d9a\u304d\u3092\u8aad\u3080]<\/a>","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.igakuken.or.jp\/genome\/index.php?rest_route=\/wp\/v2\/pages\/119"}],"collection":[{"href":"https:\/\/www.igakuken.or.jp\/genome\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.igakuken.or.jp\/genome\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.igakuken.or.jp\/genome\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.igakuken.or.jp\/genome\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=119"}],"version-history":[{"count":61,"href":"https:\/\/www.igakuken.or.jp\/genome\/index.php?rest_route=\/wp\/v2\/pages\/119\/revisions"}],"predecessor-version":[{"id":4130,"href":"https:\/\/www.igakuken.or.jp\/genome\/index.php?rest_route=\/wp\/v2\/pages\/119\/revisions\/4130"}],"wp:attachment":[{"href":"https:\/\/www.igakuken.or.jp\/genome\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=119"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}