研究業績　過去5年間 (2014～2018年)

2018年

  1. Nishimura T, Kaminuma O, Saeki M, Kitamura N, Gotoh M, Mori A, Hiroi T. Effects of anti-allergic drugs on T cell-mediated nasal hyperresponsiveness in a murine model of allergic rhinitis. Allergol Int. 2018. In press.
  2. Gotoh M, Kaminuma O, Hiroi T, Okubo K. Microarray-based multivariate analysis of the effectiveness of sublingual immunotherapy for cedar pollinosis. Allergy, Asthma and Immunology Research. In press.
  3. Shimada K, Gotoh M, Okubo K, Hiroi T, Kaminuma O, Nakaya A. Serum cytokine interactions are implicated in the mechanism of action of sublingual immunotherapy for Japanese cedar pollinosis. Journal of nippon medical school. 2018. In press.
  4. Gotoh M, Kaminuma O, Nakaya A, Katayama K, Watanabe N, Saeki M, Nishimura T, Kitamura N, Okubo K, Hiroi T. Involvement of taste receptors in the effectiveness of sublingual immunotherapy. Allergol Int. 2018. pii: S1323-8930(18)30008-X. doi: 10.1016/j.alit.2018.02.003.
  5. Kaminuma O, Katoh S, Miyagi T, Watanabe N, Kitamura N, Nishimura T, Saeki M, Mori A, Hiroi T. Contribution of neuraminidase 3 to the differentiation of induced regulatory T cells. Genes Cells. 23(2):112-116, 2018.
  6. Kaminuma O, Nishimura T, Kitamura N, Saeki M, Hiroi T, Mori A. T helper type 2 cells confer antigen-induced eosinophilic skin inflammation in mice. Allergy Asthma Immunol Res, 10(1):77-82, 2018.
  7. Kaminuma O, Kitamura N, Nishito Y, Nemoto S, Tatsumi H, Mori A, Hiroi T. Down-regulation of NFAT3 due to lack of T-box transcription factor TBX5 is crucial for cytokine expression in T cells. J Immunol. 200(1):92-100, 2018.

    8. 2017年

    1. Kaminuma O, Saeki M, Nishimura T, Kitamura N, Watanabe N, Hiroi T, Mori A. Differential contribution of adhesion molecules to Th1 and Th2 cell-mediated lung and bowel inflammation. Biol Pharm Bull, 40(10):1801-1805, 2017. Biol Pharm Bull, 40(10):1801-1805, 2017.
    2. Gotoh M, Kaminuma O, Nakaya A, Katayama K, Motoi Y, Watanabe N, Saeki M, Nishimura T, Kitamura N, Yamaoka K, Okubo K, Hiroi T. Identification of biomarker sets for predicting the efficacy of sublingual immunotherapy against pollen-induced allergic rhinitis. Int Immunol. 29(6):291-300, 2017.
    3. Saeki M, Kaminuma O, Nishimura T, Kitamura N, Mori A, Hiroi T. Th9 cells induce steroid-resistant bronchial hyperresponsiveness in mice. Allergol Int. 66S:S35-40, 2017.
    4. Kaminuma O, Inoue K, Saeki M, Katayama K, Mori A, Ogura A. Rapid development of antigen-induced airway inflammation in cloned mice generated by nuclear transfer of antige-specific CD4+ T cells. Nihon Yakurigaku Zasshi. 150(2):83-87, 2017.
    5. Hiraide E, Morinaga M, Hidaka H, Yamada S, Takeyama J, Kitamura N, Kaminuma O, Hiroi T, Du W, Ohashi-Doi K, Nakajima-Adachi H, Hachimura S. Oral administration of ovalbumin after sensitization attenuates symptoms in a mouse model of food allergic enteropathy. Biosci Biotechnol Biochem. 81(10):1967-1972, 2017.
    6. Kaminuma O, Katayama K, Inoue K, Saeki M, Nishimura T, Kitamura N, Shimo Y, Tofukuji S, Ishida S, Ogonuki N, Kamimura S, Oikawa M, Katoh S, Mori A, Shichijo M, Hiroi T, Ogura A. Hyper-reactive cloned mice generated by direct nuclear transfer of antigen-specific CD4+ T cells. EMBO Rep. 18(6):885-893, 2017.

    2016年

    1. Saeki M, Kaminuma O, Nishimura T, Kitamura N, Mori A, Hiroi T. Th9 cells elicit eosinophil-independent bronchial hyperresponsiveness in mice. Allergol Int. 65: S24-29, 2016.
    2. Nishimura T, Katoh S, Mori A, Ohtomo T, Saeki M, Hiroi T and Kaminuma O. Critical role of CD44 in antigen-induced Th2- but not Th17-madiated murine airway inflammation. Allergol Int. 65:S59-61, 2016.
    3. Saeki M, Kaminuma O, Nishimura T, Kitamura N, Mori A, Hiroi T. Crosstalk between histamine and T cells in allergic diseases. Curr Immunol Rev. 12: 10-13. 2016.
    4. Watanabe N, Kaminuma O, Kitamura N, Hiroi T. Induced Treg cells augment the Th17-mediated intestinal inflammatory response in a CTLA4-dependent manner. PLoS One. 11: e0150244, 2016.
    5. Murakami R, Nakagawa Y, Shimizu M, Wakabayashi A, Negishi Y, Hiroi T, Okubo K, Takahashi H. Effects of Dendritic Cell Subset Manipulation on Airway Allergy in a Mouse Model.Int Arch Allergy Immunol. 168: 219-32. 2016.
    6. Nishimura T, Kaminuma O, Saeki M, Kitamura N, Matsuoka K, Yonekawa H, Mori A, Hiroi T. Essential contribution of T cells to antigen-induced nasal hyperresponsiveness in experimental allergic rhinitis. PLoS One. 11: e0146686, 2016.

    2015年

    1. Yokoyama S, Perera PY, Terawaki S, Watanabe N, Kaminuma O, Waldmann TA, Hiroi T, Perera LP. Janus kinase inhibitor tofacitinib shows potent efficacy in a mouse model of autoimmune lymphoproliferative syndrome(ALPS). J Clin Immunol 35: 661-667, 2015.
    2. Takagi H, Watanabe N, Hiroi T, Takaiwa F. Efficacy of transgenic rice containing human interleukin-10 in experimental mouse models of colitis and pollen allergy. Plant Biotechnol 32: 329-332, 2015.
    3. Wakasa Y, Takagi H, Watanabe N, Kitamura N, Fujiwara Y, Ogo Y, Hayashi S, Yang L, Ohta M, Thet Tin WW, Sekikawa K, Takano M, Ozawa K, Hiroi T, Takaiwa F. Concentrated protein body product derived from rice endosperm as an oral tolerogen for allergen-specific immunotherapy – a new mucosal vaccine formulation against Japanese cedar pollen allergy. PLoS One 10: e0120209, 2015.
    4. Saeki M, Nishimura T, Kaminuma O, Ohtsu H, Mori A, Hiroi T. Crosstalk between Histamine and T cells in Allergic Diseases. Current Immunology Reviews. 2015, vol 11
    5. 神沼 修、渡邊伸昌、佐伯 真弓、廣井隆親、森 晶夫．特集　色々なアレルギー疾患における最近の進歩　I．内科．２．Th細胞分化とアレルギー．アレルギー・免疫． 22: 34-42, 2015
    6. 神沼 修、後藤 穣、中谷明弘、大久保公裕、廣井隆親．特集　疾患バイオマーカー研究の新展開．免疫療法の応答性に関わるバイオマーカー：アンサン ブル学習法によるスギ花粉症の治療効果を判定する血清バイオマーカーセットの同定．日本薬理学雑誌．146: 259-262, 2015.

    2014年

    1. Mori D, Watanabe N, Kaminuma O, Murata T, Hiroi T, Ozaki H, Hori M. IL-17A induces hypo-contraction of intestinal smooth muscle via induction of iNOS in muscularis macrophages. J Pharmacol Sci. 125: 394-405, 2014.
    2. Saeki M, Nishimura T, Mori A, Kaminuma O, Hiroi T. Antigen-induced mixed and separated inflammation in murine upper and lower airways. Allergol Int. 63: S59-61, 2014.
    3. Nishimura T, Saeki M, Motoi Y, Kitamura N, Mori A, Kaminuma O, Hiroi T. Selective suppression of th2 cell-mediated lung eosinophilic inflammation by anti-major facilitator super family domain containing 10 monoclonal antibody. Allergol Int. 63: S29-35, 2014.
    4. Shibahara K, Adachi NH, Kaminuma O, Hiroi T, Mori A, Hachimura S. Food allergen-induced IgE response mouse model created by injection of in vitro differentiated Th2 cell culture and oral antigen intake. Bioscience of Microbiota, Food and Health, 33: 41-6, 2014.
    5. Tsudukibashi O, Saito M, Kobayashi T, Umezawa K, Nagahama F, Hiroi T, Hirasawa M, Takada K. A gene cluster for the synthesis of serotype g-specific polysaccharide antigen in Aggregatibacter actinomycetemcomitans, Archives of Microbiology, 196: 261-5, 2014.
    6. Yin Y, Cai X, Chen X, Liang H, Zhang Y, Li J, Wang Z, Chen X, Zhang W, Yokoyama S, Wang C, Li L, Li L, Hou D, Dong L, Xu T, Hiroi T, Yang F, Ji H, Zhang J, Zen K, Zhang CY. Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth. Cell Res. 24: 1164-80, 2014.
    7. Nishimura T, Saeki M, Kaminuma O, Takaiwa F, Hiroi T. Transgenic plants for allergen-specific immunotherapy. World J Immunol. 4: 141-8, 2014.
    8. 神沼修, 後藤穣, 中谷明弘, 大久保公裕, 廣井隆親．特集: 色々なアレルギー疾患における最近の進歩　I．内科．２．Th細胞分化とアレルギー 「アレルギー・免疫」(医薬ジャーナル社) 22(1): 34-42, 2016.

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