研究業績 ACHIEVEMENT

原著論文

平成28年度

  1. Hayashi M, Sakuma H. Immunohistochemical Analysis of Brainstem Lesions in the Autopsy Cases with Severe Motor and Intellectual Disabilities Showing Sudden Unexplained Death. Front Neurol. 2016 7:93.
  2. Miyata R, Tanuma N, Sakuma H, Hayashi M. Circadian Rhythms of Oxidative Stress Markers and Melatonin Metabolite in Patients with Xeroderma Pigmentosum Group A. Oxid Med Cell Longev. 2016; 5741517.
  3. Omata T, Takahashi Y, Sakuma H, Tanaka K, Fujii K, Shimojo N, et al. Ovarian teratoma development after anti-NMDA receptor encephalitis treatment. Brain Dev. 2016 39:448-451.
  4. Fujita Y, Takanashi J, Takei H, Ota S, Fujii K, Sakuma H, Hayashi M. Activated microglia in acute encephalopathy with biphasic seizures and late reduced diffusion. J Neurol Sci. 2016;366:91-3.
  5. Takasawa K, Takeda S, Nishioka M, Sakuma H, Morio T, Shimohira M. Steroid-responsive status epilepticus caused by human parvovirus B19 encephalitis. Pediatr Infect Dis J. 2016;35:227-8.
  6. Tamasaki A*, Saito Y, Ueda R, Ohno K, Yokoyama K, Satake T, Sakuma H, Takahashi Y, Kondoh T, Maegaki Y. Effects of donepezil and serotonin reuptake inhibitor on acute regression during adolescence in Down syndrome. Brain Dev. 2016 38:113-7.

平成27年度

  1. Sakuma H, Tanuma N, Kuki I, Takahashi Y, Shiomi M, Hayashi M. Intrathecal overproduction of proinflammatory cytokines and chemokines in febrile infection-related refractory status epilepticus. J Neurol Neurosurg Psychiatr. 2015;86:820-2.
  2. Nakahara E, Sakuma H, Kimura-Kuroda J, Shimizu T, Okumura A, Hayashi M. A diagnostic approach for identifying anti-neuronal antibodies in children with suspected autoimmune encephalitis. J Neuroimmunol 2015:285:150-5.
  3. Higurashi N, Takahashi Y, Kashimada A, Sugawara Y, Sakuma H, at al. Immediate suppression of seizure clusters by corticosteroids in PCDH19 female epilepsy. Seizure 2015 27:1-5.
  4. Kimura K, Nagao Y, Hachimori K, Hayashi M, Nomura Y, Segawa M. Pre-movement gating of somatosensory evoked potentials in Segawa disease. Brain Dev (in press)　2015 Jun 11. doi: 10.1016/j.braindev.2015.05.007.
  5. Shimojima K, Okumura A, Hayashi M, Kondo T, Inoue H, Yamamoto T. CHCHD2 is down-regulated in neuronal cells differentiated from iPS cells derived from patients with lissencephaly Genomics 2015 Oct;106(4):196-203.
  6. Kubota M, Ohta S, Ando A, Koyama A, Terashima H, Kashii H, Hoshino H, Sugita K, Hayashi M. Nationwide survey of Cockayne syndrome in Japan: its incidence, clinical course and prognosis. Pediatr Int 2015 Jun;57(3):339-47.
  7. Ozaki K, Sanjo N, Ishikawa K, Higashi M, Hattori T, Tanuma N, Miyata R, Hayashi M, Yokota T, Okawa A, Mizusawa H. Elevation of 8-hydroxy-2′-deoxyguanosine in the cerebrospinal fluid of three patients with superficial siderosis. Neurol Clin Neurosci 2015 May:3(3):108-110
  8. Palmela P, Pereila P, Hayashi M, Brites D, Brito A. Histological findings in the kernicterus-associated vulnerable brain regions are linked to neurodegeneration, alterations in astrocyte and pericyte distribution, and vascular modifications. Int J Pathol Clin Res 1:003. 2015;1(1):11 pages, published in April 29, 2015.

    9. 平成26年度

  9. Tanuma N, Miyata R, Nakajima K, Okumura A, Kubota M, Hamano S, Hayashi M. Cerebrospinal fluid oxidative stress markers and tau protein in human herpesvirus-6 associated acute encephalopathy/febrile seizures. Mediators Inflamm 2014 (in press) doi: 10.1155/2014/564091.
  10. Miyata R, Hayashi M, Itoh E. Pathological changes in the cardiac muscles and the cerebellar cortex in Vici syndrome. Am J Med Genet A 2014 (in press) doi: 10.1002/ajmg.a.36753.
  11. Okoshi Y, Tanuma N, Miyata R, Hayashi M. Melatonin alterations and brain acetylcholine lesions in sleep disorders in Cockayne syndrome. Brain Dev 2014 (in press). doi: 10.1016/j.braindev.2014.01.004.
  12. Okoshi Y, Hayashi M, Kanda S, Yamamoto T. An autopsy case of microencephaly, bizarre putaminal lesion, and cerebellar atrophy with heart and liver diseases. Brain Dev 2014 (in press). doi: 10.1016/j.braindev.2013.11.010.
  13. Noto D and Sakuma H (double first authors), Takahashi K, Saika R, Saga R, Yamada M, Yamamura T, Miyake S. Development of a culture system to induce microglia-like cells from haematopoietic cells. Neuropathol Appl Neurobiol 2014; 40: 697-713.
  14. 1. Itoh M, Iwasaki Y, Ohno K, Inoue T, Hayashi M, Ito S, Matsuzaka T, Ide S, Arima M. Nationwide survey of Arima syndrome: Revised diagnostic criteria from epidemiological analysis. Brain Dev 2014; 36(5): 388-393
  15. 福水道郎、林雅晴、宮島祐、石崎朝世、田中肇、神山潤．メラトニン、ラメルテオン小児使用例に関する全国調査．脳と発達（in press）

    16. 平成25年度

  16. Hachiya Y, Uruha A, Kasai-Yoshida E, Shimoda K, Satoh-Shirai I, Kumada S, Kurihara E, Suzuki K, Ohba A, Hamano SI, Sakuma H. Rituximab ameliorates anti-N-methyl-d-aspartate receptor encephalitis by removal of short-lived plasmablasts. J Neuroimmunol 2013; 265(1-2): 128-130.
  17. Hachiya Y, Miyata R, Tanuma N, Hongo K, Tanaka K, Shimoda K, Kanda S, Hoshino A, Hanafusa Y, Kumada S, Kurihara E, Hayashi M. Autoimmune neurological disorders associated with group-A beta-hemolytic streptococcal infection. Brain Dev 2013; 35(7): 670-674.
  18. Saito T, Saito Y, Sugai K, Nakagawa E, Komaki H, Okazaki T, Ishido Y, Kaneko Y, Kaido T, Takahashi A, Ohtsuki T, Sakuma H, Sasaki M. Late-onset epilepsy in children with acute febrile encephalopathy with prolonged convulsions: A clinical and encephalographic study. Brain Dev 2013; 35(6): 531-539.
  19. Okumura A, Hayashi M, Shimojima K, Ikeno M, Uchida T, Takanashi JI, Okamoto N, Hisata K, Shoji H, Saito A, Furukawa T, Kishida T, Shimizu T, Yamamoto T. Whole-exome sequencing of a unique brain malformation with periventricular heterotopia, cingulate polymicrogyria and midbrain tectal hyperplasia. Neuropathology 2013; 33(5): 553-560.
  20. Shiohama T, Fujii K, Hayashi M, Hishiki T, Suyama M, Mizuochi H, Uchikawa H, Yoshida S, Yoshida H, Kohno Y. Phrenic nerve palsy associated with birth trauma – case reports and a literature review. Brain Dev 2013; 35(4): 361-366.
  21. Segawa M, Nomura Y, Hayashi M. Dopa-responsive dystonia is caused by particular impairment of nigrostriatal dopamine neurons different from those involved in Parkinson disease: evidence observed in studies on Segawa disease. Neuropediatrics 2013; 44(2): 61-66.
  22. Okumura A, Lee T, Ikeno M, Shimojima K, Kajino K, Inoue Y, Yoshikawa N, Suganuma H, Suzuki M, Hisata K, Shoji H, Takanashi J, Barkovich AJ, Shimizu T, Yamamoto T, Hayashi M. A severe form of epidermal nevus syndrome associated with brainstem and cerebellar malformations and neonatal medulloblastoma Brain Dev 2013; 35(3): 274-279.
  23. Igarashi A, Okumura A, Kitamura Y, Jinbo K, Akatsuka S, Tanuma N, Shimizu T, Hayashi M. Acute limbic encephalitis with focal hyperperfusion on single photon emission computed tomography. Brain Dev 2013; 35(2): 181-184.
  24. Cullup T, Kho AL, Dionisi-Vici C, Brandmeier B, Smith F, Urry Z, Simpson MA, Yau S, Bertini E, McClelland V, Al-Owain M, Koelker S, Koerner C, Hoffmann GF, Wijburg FA, Hoedt AE, Rogers RC, Manchester D, Miyata R, Hayashi M, Said E, Soler D, Kroisel PM, Windpassinger C, Filloux FM, Al-Kaabi S, Hertecant J, Del Campo M, Buk S, Bodi I, Goebel HH, Sewry CA, Abbs S, Mohammed S, Josifova D, Gautel M, Jungbluth H. Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy. Nat Genet 2013; 45(1): 83-87.
  25. 中島啓介、林雅晴．福山型先天性筋ジストロフィー剖検例での脳幹機能の検討．脳と発達 2013; 45(6): 436-439.

    26. 平成24年度

  26. Hachiya Y, Hayashi M, Negishi T, Atsumi S, Kubota M, Nishihara T. A case of osteogenesis imperfecta type II caused by a novel COL1A2 gene mutation: endoscopic third ventriculostomy to prevent hydrocephalus. Neuropediatrics 2012; 43(4): 225-228.
  27. Takanashi J, Hayashi M, Yuasa S, Satoh H, Terada H. Hypomyelination in I-cell disease; MRI, MR spectroscopy and neuropathological correlation. Brain Dev 2012;34(9):780-783.
  28. Kitamura Y, Okumura A, Hayashi M, Mori H, Takahashi S, Yanagihara K, Miyata R, Tanuma N, Mimaki T, Abe S, Shimizu T. Oxidative stress markers and phosphorus magnetic resonance spectroscopy in a patient with GLUT1 deficiency treated with modified Atkins diet. Brain Dev 2012;34(5):372-375.
  29. Miyata R, Tanuma N, Hayashi M, Takahashi Y. Focal encephalopathy having recurrent episodes of epileptic status and cluster mimicking hemiconvulsion-hemiplegia-epilepsy syndrome. Brain Dev 2012;34(5):360-363.
  30. 1. Hayashi M, Oto T, Shioda K, Fukatsu R. Lesions of cortical GABAergic interneurons and acetylcholine neurons in xeroderma pigmentosum group A. Brain Dev 2012; 34(4): 287-292.
  31. Hayashi M, Saito-Miwa N, Tanuma N, Kubota M. Brain vascular changes in Cockayne syndrome. Neuropathology 2012; 32(2): 113-117.
  32. Nakajima K, Hayashi M, Tanuma N, Morio T. An autopsy case of polymicrogyria and intracerebral calcification dying the intracerebral hemorrhage. Neuropathology 2012; 32(2): 107-110.
  33. Kuroda-Kimura J, Kuroda Y, Hayashi M, Kawano H. Nicotine-like effects of the neonicotinoid insecticides acetamiprid and imidacloprid on cerebellar neurons of neonatal rats. PLoS ONE 2012; 7(2): e32432.
  34. Tanaka R, Iwasaki N, Hayashi M, Nakayama J, Ohto T, Takahashi M, Numano T, Homma K, Hamano K, Sumazaki R. Abnormal brain MRI signal in 18q- syndrome not due to dysmyelination. Brain Dev 2012; 34(3): 234-237.
  35. Inui T, Saito Y, Sakuma H, Hatakeyama H, Goto YI, Arai H, Sasaki M. Profiles of blood biomarkers in alternating hemiplegia of childhood - Increased MMP-9 and decreased substance P indicates its pathophysiology. Brain Dev 2012; 34(3): 196-200.
  36. Miyata R, Hayashi M, Tanuma N, Imamura T, Takanashi J, Nagata R, Okumura A, Kashii H, Tomita S, Kumada S, Kubota M. Oxidative stress in mild encephalitis/encephalopathy with a reversible splenial lesion (MERS). Brain Dev 2012; 34(2): 124-127.

    37. 平成23年度

  37. Hayashi M, Miyata R, Tanuma N. Decrease in acetylcholinergic neurons in the pedunculopontine tegmental nucleus in a patient with Prader-Willi syndrome. Neuropathology 2011; 31(3):280-285.
  38. Sakuma H, Katayama A, Saito Y, Komaki H, Nakagawa E, Sugai K, Sasaki M. CD4+ CD25(high) regulatory T cell in childhood ocular myasthenia gravis. Brain Dev 2011; 33(5):442-444.
  39. Shioda M, Hayashi M, Takanashi J, Osawa M. Lesions in the central tegmental tract in autopsy cases of developmental brain disorders. Brain Dev 2011:33(7):541-547.
  40. Hanai S, Komaki H, Sakuma H, Nakagawa E, Sugai K, Sasaki M, Oya Y, Higurashi N, Hamano S. Acute autonomic sensory and motor neuropathy associated with parvovirus B19 infection. Brain Dev 2011; 33(2):161-165.
  41. 林雅晴. 運動障害・嚥下障害で発症し2年11カ月の経過で死亡した3歳女性. 脳と発達 2011; 43(2): 3-4.
  42. 安西有紀、林雅晴、松岡正樹、高橋宏行、宮田理英、田沼直之、大矢達男．パンデミック（H1N1）2009インフルエンザ感染により脳幹病変を呈した急性脳症の1例．脳と発達 2011; 43(1): 57-59.
  43. 林雅晴. 運動障害・嚥下障害で発症し2年11カ月の経過で死亡した3歳女性. 脳と発達 2011; 43(1): 85-86.

    44. 平成22年度

  44. Hayashi M, Hachiya Y, Arai N. An autopsy report of case showing repetitive hypoglycemia and unique cortical dysplasia. Brain Dev 2010; 32 (4): 289-292.
  45. Sakuma H, Sugai K, Sasaki M. Acute nonparaneoplastic limbic encephalitis in childhood: a case series in Japan. Pediatr Neurol 2010; 43(3): 167-172.
  46. Sakuma H, Awaya Y, Shiomi M, Yamanouchi H, Takahashi Y, Saito Y, Sugai K, Sasaki M. Acute encephalitis with refractory, repetitive partial seizures (AERRPS): a peculiar form of childhood encephalitis. Acta Neurol Scand 2010; 121(4):251-256.
  47. Sakuma H, Shimizu Y, Saito Y, Sugai K, Inagaki M, Kaga M, Sasaki M. Electrophysiological evidence of cerebral dysfunction in childhood opsoclonus-myoclonus syndrome. Mov Disord 2010; 25(7): 940-945.
  48. Itoh M, Takizawa Y, Hanai S, Okazaki S, Miyata R, Inoue T, Akashi T, Hayashi M, Goto YI. Partial loss of pancreas endocrine and exocrine cells of human ARX-null mutation: consideration of pancreas differentiation. Differentiation 2010; 80(2-3): 118-122.
  49. Suganuma H, Arai Y, Kitamura Y, Hayashi M, Okumura A, Shimizu T. Maternal docosahexaenoic acid-enriched diet prevents neonatal brain injury. Neuropathology 2010; 30(6): 597-605.
  50. Negi M, Kobayashi D, Kumagai J, Kuroiwa T, Shiraishi J, Takemura T, Irahara K, Hayashi M, Eishi Y. An autopsy case of congenital hydrocephalus and severe thinning of the cerebral cortex in a 4-year-old boy. Neuropathology 2010; 30(5): 559-563.
  51. Miyata R, Sasaki T, Hayashi M, Araki S, Shimohira M, Kohyama J. Low dose of levodopa is effective for laryngeal dystonia in xeroderma pigmentosum group A. Brain Dev 2010; 32(8): 685-687.
  52. Tanuma N, Miyata R, Kumada S, Kubota M, Takanashi J, Okumura A, Hamano S, Hayashi M. The axonal damage marker tau protein in the cerebrospinal fluid is increased in patients with acute encephalopathy with biphasic seizures and late reduced diffusion. Brain Dev 2010; 32(6): 435-439.
  53. Oba D, Hayashi M, Minamitani M, Hamano S, Uchisaka N, Kikuchi A, Kishimoto H, Takagi M, Morio T, Mizutani S. Autopsic study of cerebellar degeneration in siblings with ataxia-telangiectasia-like disorder (ATLD). Acta Neuropathol 2010; 119(4): 513-520.
  54. Kanda S, Saito M, Hayashi M, Atsumi S, Komine S, Tanuma N. Hypoglossal hypoplasia and hyperplasia of the area postrema following perinatal hypoxic brain damage. Brain Dev 2010; 32(4): 285-288.
  55. Sekigawa M, Okumura A, Niijima S, Hayashi M, Tanaka K, Shimizu T. Autoimmune focal encephalitis shows marked hypermetabolism on positron emission tomography. J Pediatrics 2010; 156(1): 158-160.
  56. Saito Y, Inui T, Sakakibara T, Sugai K, Sakuma H, Sasaki M. Evolution of hemiplegic attacks and epileptic seizures in alternating hemiplegia of childhood. Epilepsy Res 2010; 90: 248-258.
  57. 三輪菜穂、田沼直之、*林雅晴．著明な高IgE血症を呈した重症心身障害児の剖検例．脳と発達 2010; 42(5): 367-371.
  58. 1. 白井謙太郎、中島啓介、渡辺章充、川野豊、林雅晴. 運動中に発症した中脳周囲非動脈瘤性クモ膜下出血の6歳女児例. 脳と発達 2010; 42(1): 60-62.（

総説論文

平成27年度

  1. *佐久間啓. 溶連菌感染と関連した自己免疫性神経疾患と抗大脳基底核抗体．増刊号「免疫性神経疾患」日本臨床 2015; 73増刊号7．
  2. *林雅晴. 正常発達を評価するポイント. 病理と臨床2015; 33(4): 373-379.
  3. *林雅晴. 進行性ミオクローヌスてんかん. 小児内科2015; 47(9): 1644-1648.

    4. 平成26年度

  4. *佐久間啓. 自己抗体と脳炎．炎症と免疫 2015; 23(2).
  5. 林雅晴. 良性家族性新生児けいれん・良性特発性新生児けいれん.小児科2014; 55(7): 1139-1143

    6. 平成25年度

  6. *佐久間啓. 難治頻回部分発作重積型急性脳炎をめぐる最近の話題．脳と発達 2013; 45(2): 110-114.
  7. *林雅晴. 病理所見からの重症心身障害の病態の理解. 日本重症心身障害学会誌 2013; 38(1): 19-25.
  8. *林雅晴. 抗大脳基底核抗体. BRAIN and NERVE 2013; 65(4): 377-384.
  9. *田沼直之、林雅晴．エダラボン．小児内科2013; 45(2): 253-256.
  10. *林雅晴. 脳炎・脳症・髄膜炎の病理所見からわかること. 小児内科2013; 45(2): 191-194.

    11. 平成24年度

  11. *Hayashi M, Nakajima K, Miyata R, Tanuma N, Kodama T. Lesion of acetylcholine neurons in refractory epilepsy. In: ISRN Neurology (ISSN: 2090-5513 doi:10.5402/NEUROLOGY). Hindawi Publishing Corporation, Volume 2012, Article ID 404263. doi:10.5402/2012/404263.（査読有）
  12. *Hayashi M, Tanuma N, Miyata R. Oxidative stress in developmental brain disorders. In: Ahmad S, eds. Neurodegenerative diseases. Adv Exp Med Biol 2012; 724: 278-290.
  13. 松岡貴子，*佐久間啓. 神経疾患と免疫. 小児内科2012; 44: 1416-1422.

    14. 平成23年度

  14. *林雅晴. 色素性乾皮症の神経病変. Visual Dermatology 2011; 10(5):456-458.
  15. *林雅晴. けいれんの機序と病態. 小児内科2011; 43(3): 359-363.
  16. *佐久間啓．粟屋福山症候群．小児科診療 2011; 74: 986-90
  17. *佐久間啓．特異な脳炎・脳症後てんかんの一群(福山-粟屋).小児内科 2011; 43: 506-508.

    18. 平成22年度

  18. *林雅晴. 難治性てんかんの神経病理. 日本小児臨床薬理学会雑誌2010; 23(1): 17-22.
  19. *佐久間啓. 小児の自己免疫性神経疾患　脳炎を中心に 日本小児科学会雑誌 2010; 114: 1665-72.

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