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Calpain Project

Calpain Project

Significance

Calpain is an enzyme that regulates cells and thus, biological organisms, by separating various intracellular proteins and converting their function and structure. For this reason, interruption to the effective working of calpain will lead to the incidence of various diseases, such as muscular dystrophy and bleeding stomach.

This project indicates directions for the diagnosis and treatment of disease by analyzing how calpain adjusts the function of cells at the molecular level and clarifying the mechanisms behind the onset of these diseases.

Objectives

  • To analyze the action mechanism of calpain at the molecular level and clarify its physiological function
  • To analyze the disease onset mechanisms in disease models such as mice with genetic modifications to calpain and other enzymes.
  • To analyze changes in related molecules in diseases marked by calpain deficiency and point out directions for diagnosis and treatment

Member

Project Leader Hiroyuki Sorimachi

  • Yasuko Ono
  • Shoji Hata
  • Fumiko Shinkai-ouchi
Project Leader Hiroyuki Sorimachi

Leader Hiroyuki Sorimachi

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