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Elucidation of Pathology and Development of Therapeutic Strategies for Retinal Neurodegenerative Diseases

Project Leader Takayuki Harada

Takayuki Harada


More than 1.6 million people in Japan are visually impaired, representing economic social losses estimated at more than 8 trillion yen. In the particular context of the increased penetration of Western lifestyles and an aging society, the increase in the number of patients with conditions such as glaucoma and diabetic retinopathy, which could be called “adult eye diseases,” has become a major social issue.

To achieve improved quality of life (QOL) for the visually impaired in an increasingly aging population, this study seeks to elucidate detailed pathogenic mechanism and develop new therapies through the development of a model of intractable eye disease.


  • To develop a neuroprotective retinal therapy using an animal disease models
  • To elucidate the mechanisms involved in the onset of optic neuritis
  • To establish a method to promote regeneration of the optic nerve