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Development of Novel Therapeutics that Block Viral Infectivity

Project Leader Satoshi Koike

Leader Satoshi Koike


Viral epidemics in Japan and overseas have led to the deterioration of health and socioeconomic losses. Since viruses cause disease through their replication in hosts, it is important to analyze factors on both the part of the virus and that of the host to establish measures of prevention and treatment.

This project discusses the enterovirus, which has resulted in pandemics across Asia as well as influenza viruses and clarifies the mechanisms of viral replication in order to develop research that will lead to the development of therapeutic drugs.


  • To clarify the host-side and viral-side factors that govern the virulence of enterovirus 71
  • To further the development of anti-influenza drugs that will inhibit RNA polymerase activity in the influenza virus