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Ubiquitin Signaling and Ubiquitin-related Disorders Project

Project Leader Noriyuki Matsuda

Leader
Noriyuki Matsuda

Backgrounds

In cells, ubiquitin governs the life and death of various proteins and cell organelles as a factor that determines their fate. In recent years, it has been suggested that ubiquitin abnormalities are closely related to various diseases including Parkinson’s.

This project, along with elucidating ubiquitin’s role in the body, which until now has been shrouded in mystery, seeks to reveal its association with neurodegenerative diseases such as Parkinson’s.

Objectives

  • To pay attention to ubiquitin when examining the pathogenesis of neurodegenerative diseases such as Parkinson’s
  • To produce an animal disease model through modification of the in vivo ubiquitin environment
  • To help maintain people’s health by clarifying the function that ubiquitin plays in various roles in the body
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