Achievement

主要研究業績

  1. Namekata K, Guo X, Kimura A, Arai N, Harada C, Harada T.
    DOCK8 is expressed in microglia, and it regulates microglial activity during neurodegeneration in murine disease models.
    Journal of Biological Chemistry 294: 13421-13433, 2019.
    https://www.ncbi.nlm.nih.gov/pubmed/31337702
  2. Noro T, Namekata K, Kimura A, Azuchi Y, Hashimoto N, Moriya-Ito K, Komaki Y, Lee CY, Okahara N, Guo X, Harada C, Kim E, Nakano T, Tsuneoka H, Inoue T, Sasaki E, Tokuno H, Harada T.
    Normal tension glaucoma-like degeneration of the visual system in aged marmosets.
    Scientific Reports 9: 14852, 2019.
    https://www.ncbi.nlm.nih.gov/pubmed/31619716
  3. Honda S, Namekata K, Kimura A, Guo X, Harada C, Murakami A, Matsuda A, Harada T.
    Survival of alpha and intrinsically photosensitive retinal ganglion cells in NMDA-induced neurotoxicity and a mouse model of normal tension glaucoma.
    Investigative Ophthalmology & Visual Science 60: 3696-3707, 2019.
    https://www.ncbi.nlm.nih.gov/pubmed/31487370
  4. Wiltrout K, Ferrer A, van de Laar I, Namekata K, Harada T, Klee EW, Zimmerman MT, Cousin MA, Kempainen JL, Babovic-Vuksanovic D, van Slegtenhorst MA, Aarts-Tesselaar CD, Schnur RE, Andrews M, Shinawi M.
    Variants in DOCK3 cause developmental delay and hypotonia.
    European Journal of Human Genetics 27: 1225-1234, 2019.
    https://www.ncbi.nlm.nih.gov/pubmed/30976111
  5. Sano H, Namekata K, Kimura A, Shitara H, Guo X, Harada C, Mitamura Y, Harada T.
    Differential effects of N-acetylcysteine on retinal degeneration in two mouse models of normal tension glaucoma.
    Cell Death and Disease 10: 75, 2019.
    https://www.ncbi.nlm.nih.gov/pubmed/30692515
  6. Harada C, Kimura A, Guo X, Namekata K, Harada T.
    Recent advances in genetically modified animal models of glaucoma and their roles in drug repositioning.
    British Journal of Ophthalmology 103: 161–166, 2019.
    https://www.ncbi.nlm.nih.gov/pubmed/30366949
  7. Azuchi Y, Namekata K, Shimada T, Guo X, Kimura A, Harada C, Saito A, Yamagata K, Harada T.
    Role of neuritin in retinal ganglion cell death in adult mice following optic nerve injury.
    Scientific Reports 8: 10132, 2018.
    https://www.ncbi.nlm.nih.gov/pubmed/29973613
  8. Akaiwa K, Namekata K, Azuchi Y, Sano H, Guo X, Kimura A, Harada C, Mitamura Y, Harada, T.
    Topical ripasudil suppresses retinal ganglion cell death in a mouse model of normal tension glaucoma.
    Investigative Ophthalmology & Visual Science 59: 2080-2089, 2018.
    https://www.ncbi.nlm.nih.gov/pubmed/29677370
  9. Guo X, Namekata K, Kimura A, Harada C, Harada T.
    The Renin-angiotensin system regulates neurodegeneration in a mouse model of optic neuritis.
    American Journal of Pathology 187: 2876-2885, 2017.
    https://www.ncbi.nlm.nih.gov/pubmed/28919108
  10. Shinozaki Y, Kashiwagi K, Namekata K, Takeda A, Ohno N, Robaye B, Harada T, Iwata T., Koizumi S.
    Purinergic dysregulation causes hypertensive glaucoma-like optic neuropathy.
    JCI Insight 2: e93456, 2017.
    https://www.ncbi.nlm.nih.gov/pubmed/28978804
  11. Guo X, Kimura A, Azuchi Y, Akiyama G, Noro T, Harada C, Namekata K, Harada T.
    Caloric restriction promotes cell survival in a mouse model of normal tension glaucoma.
    Scientific Reports 6: 33950, 2016.
    https://www.ncbi.nlm.nih.gov/pubmed/27669894
  12. Kimura A, Namekata K, Guo X, Noro T, Harada C, Harada T.
    Valproic acid prevents NMDA-induced retinal ganglion cell death via stimulation of neuronal TrkB receptor signaling.
    American Journal of Pathology 185: 756-764, 2015.
    https://www.ncbi.nlm.nih.gov/pubmed/25542970
  13. Namekata K, Kimura A, Kawamura K, Harada C, Harada T.
    Dock GEFs and their therapeutic potential: Neuroprotection and axon regeneration.
    Progress in Retinal and Eye Research 43: 1-16, 2014.
    http://www.ncbi.nlm.nih.gov/pubmed/25016980
  14. Namekata K, Kimura A, Kawamura K, Guo X, Harada C, Tanaka K, Harada T.
    Dock3 attenuates neural cell death due to NMDA neurotoxicity and oxidative stress in a mouse model of normal tension glaucoma.
    Cell Death and Differentiation 20: 1250-1256, 2013.
    http://www.ncbi.nlm.nih.gov/pubmed/23852370
  15. Namekata K, Harada C, Guo X, Kimura A, Kittaka D, Watanabe H, Harada T.
    Dock3 stimulates axonal outgrowth via GSK-3β-mediated microtubule assembly.
    Journal of Neuroscience 32: 264-274, 2012.
    http://www.ncbi.nlm.nih.gov/pubmed/22219288
  16. Harada C, Guo X, Namekata K, Kimura A, Nakamura K, Tanaka K, Parada LF, Harada T.
    Glia- and neuron-specific functions of TrkB signalling during retinal degeneration and regeneration.
    Nature Communications 2: 189, 2011.
    http://www.ncbi.nlm.nih.gov/pubmed/21304518
  17. Namekata K, Harada C, Taya C, Guo X, Kimura H, Parada LF, Harada T.
    Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex.
    Proceedings of the National Academy of Sciences of the U.S.A. 107: 7586-7591, 2010.
    http://www.ncbi.nlm.nih.gov/pubmed/20368433
  18. Guo X, Harada C, Namekata K, Matsuzawa A, Camps M, Ji H, Swinnen D,Jorand-Lebrun C, Muzerelle M, Vitte P, Ruckle T, Kimura A, Kohyama K, Matsumoto Y, Ichijo H, Harada T.
    Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway.
    EMBO Molecular Medicine 2: 504-515, 2010.
    http://www.ncbi.nlm.nih.gov/pubmed/21064192
  19. Harada T, Harada C, Nakamura K, Quah HM, Okumura A, Namekata K, Saeki T, Aihara M, Yoshida H, Mitani A, Tanaka K.
    The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma.
    Journal of Clinical Investigation 117: 1763-1770, 2007.
    http://www.ncbi.nlm.nih.gov/pubmed/17607354
  20. Harada T, Harada C, Parada LF.
    Molecular regulation of visual system development: more than meets the eye.
    Genes & Development 21: 367-378, 2007.
    http://www.ncbi.nlm.nih.gov/pubmed/17322396

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