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論文
- タイトル
- タイトル（英）
- Granulocyte-macrophage colony-stimulating factor modulates rapid eye movement (REM) sleep and Non-REM sleep in rats
- 参照URL
- https://researchmap.jp/SleepLab/published_papers/34299794
- 著者
- 著者（英）
- Mayumi Kimura,Tohru Kodama,M. Cecilia Aguila,Shi Qing Zhang,Shojiro Inoué
- 担当区分
- 概要
- 概要（英）
- Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a hematopoietic cytokine that may affect various functions of the CNS because the molecule and its receptors are expressed in the brain. The present study examines the effects of GM-CSF on sleep using rats and the secretion of three neurotransmitters/hormones that are involved in sleep regulation. When infused intracerebroventricularly at doses as low as 10 pmol for 10 hr during the dark period, GM-CSF promoted predominantly rapid eye movement (REM) sleep and moderate amounts of non-REM sleep without eliciting fever. An injection of GM-CSF (3.0 pmol) into the arcuate nucleus increased the release of nitric oxide (NO) from the hypothalamus but did not alter plasma levels of growth hormone. The release of somatostatin (SRIF) from the medial basal hypothalamus was stimulated by 1 x 10-11 M GM-CSF. These findings indicated that centrally administered GM-CSF stimulates SRIF release through activation of the NO system in the hypothalamus. Because SRIF promotes REM sleep, it may also mediate the effects of GM-CSF on REM sleep. The present study indicates a novel central effect of GM-CSF that modulates sleep, supporting the notion that hematopoietic cytokines also play roles in the CNS.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Journal of Neuroscience
- 巻
- 20
- 号
- 14
- 開始ページ
- 5544
- 終了ページ
- 5551
- 出版年月
- 2000年7月15日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 0270-6474
- DOI URL
- https://doi.org/10.1523/jneurosci.20-14-05544.2000
- 共同研究・競争的資金等の研究課題
研究者
児玉 亨
( )