※ をクリックすると外部の論文のサイトが開きます。
論文
- タイトル
- タイトル（英）
- Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice
- 参照URL
- https://researchmap.jp/kazutakaikeda/published_papers/36330764
- 著者
- 著者（英）
- Mitsuaki Kashiwagi,Mika Kanuka,Kaeko Tanaka,Masayo Fujita,Ayaka Nakai,Chika Tatsuzawa,Kazuto Kobayashi,Kazutaka Ikeda,Yu Hayashi
- 担当区分
- 概要
- 概要（英）
- <title>Abstract</title>Despite the established roles of the dopaminergic system in promoting arousal, the effects of loss of dopamine on the patterns of sleep and wakefulness remain elusive. Here, we examined the sleep architecture of dopamine-deficient (DD) mice, which were previously developed by global knockout of tyrosine hydroxylase and its specific rescue in noradrenergic and adrenergic neurons. We found that DD mice have reduced time spent in wakefulness. Unexpectedly, DD mice also exhibited a marked reduction in the time spent in rapid eye movement (REM) sleep. The electroencephalogram power spectrum of all vigilance states in DD mice were also affected. These results support the current understanding of the critical roles of the dopaminergic system in maintaining wakefulness and also implicate its previously unknown effects on REM sleep.
- 出版者・発行元
- 出版者・発行元（英）
- Springer Science and Business Media LLC
- 誌名
- 誌名（英）
- Molecular Brain
- 巻
- 14
- 号
- 1
- 開始ページ
- 170
- 終了ページ
- 170
- 出版年月
- 2021年12月
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1186/s13041-021-00879-3
- 共同研究・競争的資金等の研究課題