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論文
- タイトル
- タイトル（英）
- Associations between the C3orf20 rs12496846 Polymorphism and Both Postoperative Analgesia after Orthognathic and Abdominal Surgeries and C3orf20 Gene Expression in the Brain
- 参照URL
- https://researchmap.jp/kazutakaikeda/published_papers/37111213
- 著者
- 著者（英）
- Daisuke Nishizawa,Makoto Nagashima,Shinya Kasai,Junko Hasegawa,Kyoko Nakayama,Yuko Ebata,Ken-ichi Fukuda,Tatsuya Ichinohe,Masakazu Hayashida,Kazutaka Ikeda
- 担当区分
- 概要
- 概要（英）
- Considerable individual differences are widely observed in the sensitivity to opioid analgesics. We focused on rs12496846, rs698705, and rs10052295 single-nucleotide polymorphisms (SNPs) in the C3orf20, SLC8A2, and CTNND2 gene regions that we previously identified as possibly associated with postoperative analgesia after orthognathic surgery. We investigated associations between these SNPs and postoperative analgesia in 112 patients who underwent major open abdominal surgery in hospitals and were treated with analgesics, including opioids, after surgery. Total genomic DNA was extracted from peripheral blood or oral mucosa samples for genotyping each SNP. Effects of these potent SNPs on gene expression in the brain were also investigated in samples that were provided by the Stanley Foundation Brain Bank. In the association studies, carriers of the G allele of the rs12496846 SNP in the C3orf20 gene region were significantly associated with greater 24 h postoperative analgesic requirements among the three SNPs that were investigated (p = 0.0015), which corroborated a previous study of orthognathic patients (p < 0.0001). In the gene expression analysis, carriers of the G allele of the rs12496846 SNP were significantly associated with lower mRNA expression of the C3orf20 gene (p < 0.0001). These results indicate that this SNP could serve as a marker that predicts analgesic requirements.
- 出版者・発行元
- 出版者・発行元（英）
- MDPI AG
- 誌名
- 誌名（英）
- Pharmaceutics
- 巻
- 14
- 号
- 4
- 開始ページ
- 727
- 終了ページ
- 727
- 出版年月
- 2022年3月28日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.3390/pharmaceutics14040727
- 共同研究・競争的資金等の研究課題