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論文
- タイトル
- タイトル（英）
- H-InvDB in 2013: an omics study platform for human functional gene and transcript discovery
- 参照URL
- https://researchmap.jp/yuichirohara/published_papers/15937796
- 著者
- 著者（英）
- Jun-ichi Takeda,Chisato Yamasaki,Katsuhiko Murakami,Yoko Nagai,Miho Sera,Yuichiro Hara,Nobuo Obi,Takuya Habara,Takashi Gojobori,Tadashi Imanishi
- 担当区分
- 概要
- 概要（英）
- H-InvDB (http://www.h-invitational.jp/) is a comprehensive human gene database started in 2004. In the latest version, H-InvDB 8.0, a total of 244 709 human complementary DNA was mapped onto the hg19 reference genome and 43 829 gene loci, including nonprotein-coding ones, were identified. Of these loci, 35 631 were identified as potential protein-coding genes, and 22 898 of these were identical to known genes. In our analysis, 19 309 annotated genes were specific to H-InvDB and not found in RefSeq and Ensembl. In fact, 233 genes of the 19 309 turned out to have protein functions in this version of H-InvDB; they were annotated as unknown protein functions in the previous version. Furthermore, 11 genes were identified as known Mendelian disorder genes. It is advantageous that many biologically functional genes are hidden in the H-InvDB unique genes. As large-scale proteomic projects have been conducted to elucidate the functions of all human proteins, we have enhanced the proteomic information with an advanced protein view and new subdatabase of protein complexes (Protein Complex Database with quality index). We propose that H-InvDB is an important resource for finding novel candidate targets for medical care and drug development.
- 出版者・発行元
- 出版者・発行元（英）
- OXFORD UNIV PRESS
- 誌名
- 誌名（英）
- NUCLEIC ACIDS RESEARCH
- 巻
- 41
- 号
- D1
- 開始ページ
- D915
- 終了ページ
- D919
- 出版年月
- 2013年1月
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 0305-1048
- DOI URL
- https://doi.org/10.1093/nar/gks1245
- 共同研究・競争的資金等の研究課題
研究者
原 雄一郎
( )