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論文
- タイトル
- タイトル(英)
- Identification and characterization of ligands for L-selectin in the kidney. II. Expression of chondroitin sulfate and heparan sulfate proteoglycans reactive with L-selectin
- 参照URL
- https://researchmap.jp/read0160524JA127/published_papers/38392432
- 著者
- 著者(英)
- YF Li,H Kawashima,N Watanabe,M Miyasaka
- 担当区分
- 概要
- 概要(英)
- Ligands for the leukocyte adhesion molecule L-selectin are expressed not only in lymph node high endothelial venules (HEV) but also in the renal distal tubuli, Here we report that L-selectin-reactive molecules in the kidney are chondroitin sulfate acid heparan sulfate proteoglycans of 500-1000 kDa, unlike those in HEV bearing sialyl Lewis X-like carbohydrates. Binding of L-selectin to these molecules was mediated by the lectin domain of L-selectin and required divalent cations, Binding was inhibited by chondroitinase and/or heparitinase but not sialidase, Thus, L-selectin can recognize chondroitin sulfate and heparan sulfate glycosaminoglycans structurally distinct from sialyl Lewis X-like carbohydrates. (C) 1999 Federation of European Biochemical Societies.
- 出版者・発行元
- 出版者・発行元(英)
- ELSEVIER SCIENCE BV
- 誌名
- 誌名(英)
- FEBS LETTERS
- 巻
- 444
- 号
- 2-3
- 開始ページ
- 201
- 終了ページ
- 205
- 出版年月
- 1999年2月
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文(学術雑誌)
- ISSN
- 0014-5793
- DOI URL
- 共同研究・競争的資金等の研究課題
研究者
渡邊 伸昌
( )