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論文
- タイトル
- タイトル（英）
- Pho85 Kinase, a Cyclin-Dependent Kinase, Regulates Nuclear Accumulation of the Rim101 Transcription Factor in the Stress Response of Saccharomyces cerevisiae
- 参照URL
- https://researchmap.jp/myportal_saeki-ys/published_papers/38239071
- 著者
- 著者（英）
- Masafumi Nishizawa,Mirai Tanigawa,Michio Hayashi,Tatsuya Maeda,Yoshiaki Yazaki,Yasushi Saeki,Akio Toh-e
- 担当区分
- 概要
- 概要（英）
- The budding yeast Saccharomyces cerevisiae alters its gene expression profile in response to changing environmental conditions. The Pho85 kinase, one of the yeast cyclin-dependent kinases (CDK), is known to play an important role in the cellular response to alterations in parameters such as nutrient levels and salinity. Several genes whose expression is regulated, either directly or indirectly, by the Rim101 transcription factor become constitutively activated when Pho85 function is absent,. Because Rim101 is responsible for adaptation to alkaline conditions, this observation suggests an interaction between Pho85 and Rim101 in the response to alkaline stress. We have found that Pho85 affects neither RIM101 transcription, the proteolytic processing that is required for Rim101 activation, nor Rim101 stability. Rather, Pho85 regulates the nuclear accumulation of active Rim101, possibly via phosphorylation. Additionally, we report that Pho85 and the transcription factor Pho4 are necessary for adaptation to alkaline conditions and that PTK2 activation by Pho4 is involved in this process. These findings illustrate novel roles for the regulators of the PHO system when yeast cells cope with various environmental stresses potentially threatening their survival.
- 出版者・発行元
- 出版者・発行元（英）
- AMER SOC MICROBIOLOGY
- 誌名
- 誌名（英）
- EUKARYOTIC CELL
- 巻
- 9
- 号
- 6
- 開始ページ
- 943
- 終了ページ
- 951
- 出版年月
- 2010年6月
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 1535-9778
- DOI URL
- https://doi.org/10.1128/EC.00247-09
- 共同研究・競争的資金等の研究課題
研究者
佐伯 泰
(サエキ ヤスシ)