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論文
- タイトル
- タイトル（英）
- Computational Model Exploring Characteristic Pattern Regulation in Periventricular Vessels.
- 参照URL
- https://researchmap.jp/chiakimaruyama/published_papers/42177412
- 著者
- 著者（英）
- Hisako Takigawa-Imamura,Saito Hirano,Chisato Watanabe,Chiaki Ohtaka-Maruyama,Masatsugu Ema,Ken-Ichi Mizutani
- 担当区分
- 概要
- 概要（英）
- The developing neocortical vasculature exhibits a distinctive pattern in each layer. In murine embryos, vessels in the cortical plate (CP) are vertically oriented, whereas those in the intermediate zone (IZ) and the subventricular zone (SVZ) form a honeycomb structure. The formation of tissue-specific vessels suggests that the behavior of endothelial cells is under a specific regulatory regime in each layer, although the mechanisms involved remain unknown. In the present study, we aimed to explore the conditions required to form these vessel patterns by conducting simulations using a computational model. We developed a novel model framework describing the collective migration of endothelial cells to represent the angiogenic process and performed a simulation using two-dimensional approximation. The attractive and repulsive guidance of tip cells was incorporated into the model based on the function and distribution of guidance molecules such as VEGF and Unc ligands. It is shown that an appropriate combination of guidance effects reproduces both the parallel straight pattern in the CP and meshwork patterns in the IZ/SVZ. Our model demonstrated how the guidance of the tip cell causes a variety of vessel patterns and predicted how tissue-specific vascular formation was regulated in the early development of neocortical vessels.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Life (Basel, Switzerland)
- 巻
- 12
- 号
- 12
- 開始ページ
- 終了ページ
- 出版年月
- 2022年12月9日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.3390/life12122069
- 共同研究・競争的資金等の研究課題
研究者
丸山 千秋
(マルヤマ チアキ)