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論文
- タイトル
- タイトル（英）
- [Pathogenic roles of retinal glia in glaucoma].
- 参照URL
- https://researchmap.jp/read0091842/published_papers/34628785
- 著者
- 著者（英）
- Youichi Shinozaki,Schuichi Koizumi
- 担当区分
- 概要
- 概要（英）
- Glaucoma, progressive optic neuropathy, is the first cause of blindness in Japan. Blindness in this disease is induced by damages or degeneration of retinal ganglion cells (RGCs), retinal neurons transmit visual information to brain. An elevated intraocular pressure (IOP) is widely recognized as one of the most important risk factors and that IOP directly damages RGCs by mechanical stress, however, accumulating evidences have shown that a majority of Japanese patients for primary open angle glaucoma shows normal level of IOP. Thus, new target for glaucoma pathology is emerged. In this issue, we introduce potential roles of glial cells for pathogenesis of glaucoma. In the CNS, reactive gliosis has been recognized in a variety of neurodegenerative diseases. Such glial activation is also found in retinae of human glaucoma patients and animal models. Importantly, glial activation precedes RGS degeneration, indicating the possibility that reactive glial cells actively contribute to pathogenesis of glaucoma. In this issue, we will focus on macroglial cells such as Muller cells and astrocytes, and discuss their roles in glaucoma.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Nihon yakurigaku zasshi. Folia pharmacologica Japonica
- 巻
- 155
- 号
- 2
- 開始ページ
- 87
- 終了ページ
- 92
- 出版年月
- 2020年
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1254/fpj.19120
- 共同研究・競争的資金等の研究課題
研究者
篠﨑 陽一
(シノザキ ヨウイチ)