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論文
タイトル
タイトル(英)
Adiponectin regulates the circadian rhythm of glucose and lipid metabolism
参照URL
https://researchmap.jp/Yoshitane/published_papers/40716455
著者
著者(英)
Taira Wada,Yukiko Yamamoto,Yukiko Takasugi,Hirotake Ishii,Taketo Uchiyama,Kaori Saitoh,Masahiro Suzuki,Makoto Uchiyama,Hikari Yoshitane,Yoshitaka Fukada,Shigeki Shimba
担当区分
概要
概要(英)
Adiponectin is a cytokine secreted from adipocytes and regulates metabolism. Although serum adiponectin levels show diurnal variations, it is not clear if the effects of adiponectin are time-dependent. Therefore, this study conducted locomotor activity analyses and various metabolic studies using the adiponectin knockout (APN (−/−)) and the APN (+/+) mice to understand whether adiponectin regulates the circadian rhythm of glucose and lipid metabolism. We observed that the adiponectin gene deficiency does not affect the rhythmicity of core circadian clock genes expression in several peripheral tissues. In contrast, the adiponectin gene deficiency alters the circadian rhythms of liver and serum lipid levels and results in the loss of the time dependency of very-low-density lipoprotein-triglyceride secretion from the liver. In addition, the whole-body glucose tolerance of the APN (−/−) mice was normal at CT10 but reduced at CT22, compared to the APN (+/+) mice. The decreased glucose tolerance at CT22 was associated with insulin hyposecretion in vivo. In contrast, the gluconeogenesis activity was higher in the APN (−/−) mice than in the APN (+/+) mice throughout the day. These results indicate that adiponectin regulates part of the circadian rhythm of metabolism in the liver.
出版者・発行元
出版者・発行元(英)
Bioscientifica
誌名
誌名(英)
Journal of Endocrinology
254
2
開始ページ
121
終了ページ
133
出版年月
2022年8月1日
査読の有無
招待の有無
掲載種別
研究論文(学術雑誌)
ISSN
0022-0795
DOI URL
https://doi.org/10.1530/joe-22-0006
共同研究・競争的資金等の研究課題
研究者
吉種 光 (ヨシタネ ヒカリ)