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論文
- タイトル
- タイトル（英）
- Dectin-1 and Dectin-2 promote control of the fungal pathogen Trichophyton rubrum independently of IL-17 and adaptive immunity in experimental deep dermatophytosis
- 参照URL
- https://researchmap.jp/read0134472/published_papers/7251863
- 著者
- 著者（英）
- Fabio S. Y. Yoshikawa,Rikio Yabe,Yoichiro Iwakura,Sandro R. de Almeida,Shinobu Saijo
- 担当区分
- 概要
- 概要（英）
- Dermatophytoses are chronic fungal infections, the main causative agent of which is Trichophyton rubrum (T. rubrum). Despite their high occurrence worldwide, the immunological mechanisms underlying these diseases remain largely unknown. Here, we uncovered the C-type lectin receptors, Dectin-1 and Dectin-2, as key elements in the immune response to T. rubrum infection in a model of deep dermatophytosis. Invitro, we observed that deficiency in Dectin-1 and Dectin-2 severely compromised cytokine production by dendritic cells. Invivo, mice lacking Dectin-1 and/or Dectin-2 showed an inadequate pro-inflammatory cytokine production in response to T. rubrum infection, impairing its resolution. Strikingly, neither adaptive immunity nor IL-17 response were required for fungal clearance, highlighting innate immunity as the main checkpoint in the pathogenesis of T. rubrum infection.
- 出版者・発行元
- 出版者・発行元（英）
- SAGE PUBLICATIONS LTD
- 誌名
- 誌名（英）
- INNATE IMMUNITY
- 巻
- 22
- 号
- 5
- 開始ページ
- 316
- 終了ページ
- 324
- 出版年月
- 2016年7月
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 1753-4259
- DOI URL
- https://doi.org/10.1177/1753425916645392
- 共同研究・競争的資金等の研究課題
研究者
矢部 力朗
(ヤベ リキオ)