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論文
- タイトル
- タイトル（英）
- Distributed sensory coding by cerebellar complex spikes in units of cortical segments.
- 参照URL
- https://researchmap.jp/Kakei/published_papers/45723502
- 著者
- 著者（英）
- Takayuki Michikawa,Takamasa Yoshida,Satoshi Kuroki,Takahiro Ishikawa,Shinji Kakei,Ryo Kimizuka,Atsushi Saito,Hideo Yokota,Akinobu Shimizu,Shigeyoshi Itohara,Atsushi Miyawaki
- 担当区分
- 概要
- 概要（英）
- Sensory processing is essential for motor control. Climbing fibers from the inferior olive transmit sensory signals to Purkinje cells, but how the signals are represented in the cerebellar cortex remains elusive. To examine the olivocerebellar organization of the mouse brain, we perform quantitative Ca2+ imaging to measure complex spikes (CSs) evoked by climbing fiber inputs over the entire dorsal surface of the cerebellum simultaneously. The surface is divided into approximately 200 segments, each composed of ∼100 Purkinje cells that fire CSs synchronously. Our in vivo imaging reveals that, although stimulation of four limb muscles individually elicits similar global CS responses across nearly all segments, the timing and location of a stimulus are derived by Bayesian inference from coordinated activation and inactivation of multiple segments on a single trial basis. We propose that the cerebellum performs segment-based, distributed-population coding that represents the conditional probability of sensory events.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Cell reports
- 巻
- 37
- 号
- 6
- 開始ページ
- 109966
- 終了ページ
- 109966
- 出版年月
- 2021年11月9日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1016/j.celrep.2021.109966
- 共同研究・競争的資金等の研究課題
研究者
筧 慎治
( )