※ をクリックすると外部の論文のサイトが開きます。
論文
- タイトル
- タイトル（英）
- SARS-CoV spike protein-expressing recombinant vaccinia virus efficiently induces neutralizing antibodies in rabbits pre-immunized with vaccinia virus.
- 参照URL
- https://researchmap.jp/read0088287/published_papers/46131430
- 著者
- 著者（英）
- Masahiro Kitabatake,Shingo Inoue,Fumihiko Yasui,Shoji Yokochi,Masaaki Arai,Kouichi Morita,Hisatoshi Shida,Minoru Kidokoro,Fukashi Murai,Mai Quynh Le,Kyosuke Mizuno,Kouji Matsushima,Michinori Kohara
- 担当区分
- 概要
- 概要（英）
- A vaccine for severe acute respiratory syndrome (SARS) is being intensively pursued against its re-emergence. We generated a SARS coronavirus (SARS-CoV) spike protein-expressing recombinant vaccinia virus (RVV-S) using highly attenuated strain LC16m8. Intradermal administration of RVV-S into rabbits induced neutralizing (NT) antibodies against SARS-CoV 1 week after administration and the NT titer reached 1:1000 after boost immunization with RVV-S. Significantly, NT antibodies against SARS-CoV were induced by administration of RVV-S to rabbits that had been pre-immunized with LC16m8. RVV-S can induce NT antibodies against SARS-CoV despite the presence of NT antibodies against VV. These results suggest that RVV-S may be a powerful SARS vaccine, including in patients previously immunized with the smallpox vaccine.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Vaccine
- 巻
- 25
- 号
- 4
- 開始ページ
- 630
- 終了ページ
- 7
- 出版年月
- 2007年1月8日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 0264-410X
- DOI URL
- 共同研究・競争的資金等の研究課題
研究者
安井 文彦
(ヤスイ フミヒコ)