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論文
- タイトル
- タイトル（英）
- [FLT3-ITD mutation-positive acute myeloid leukemia undergoing clonal transition with PTPN11 mutation at relapse].
- 参照URL
- https://researchmap.jp/obokikeisuke/published_papers/45891966
- 著者
- 著者（英）
- Kazuya Kurihara,Daichi Sadato,Yuho Najima,Chizuko Hirama,Kyoko Haraguchi,Kana Kato,Kaori Kondo,Yasutaka Sadaga,Chika Kato,Satoshi Sakai,Yasuhiro Kambara,Yoshimi Nabe,Koh Teshima,Kazuya Asano,Atsushi Jinguji,Masashi Shimabukuro,Fumihiko Ouchi,Kazuki Inai,Satoshi Koi,Naoki Shingai,Takashi Toya,Hiroaki Shimizu,Takeshi Kobayashi,Keisuke Oboki,Hironori Harada,Yoshiki Okuyama,Yuka Harada,Noriko Doki
- 担当区分
- 概要
- 概要（英）
- A 28-year-old man was diagnosed with acute myelomonocytic leukemia. He achieved complete remission (CR) after two cycles of induction therapy. However, after consolidation therapy, bone marrow aspiration performed to prepare for allogeneic hematopoietic stem cell transplantation revealed disease relapse. Companion diagnostics confirmed the presence of the FLT3-ITD mutation. The patient received gilteritinib monotherapy and achieved CR. Subsequently, he underwent unrelated allogeneic bone marrow transplantation. One year after transplantation, the patient relapsed, and gilteritinib was resumed. However, the leukemia progressed, and panel sequencing using a next-generation sequencer showed that the FLT3-ITD mutation disappeared. A mutation in PTPN11, which regulates the RAS/MAPK signaling pathway, was also detected. Gilteritinib was discontinued, and the patient achieved CR with salvage chemotherapy. He underwent related haploidentical peripheral blood stem cell transplantation but died of relapse. This was a case in which genetic analysis revealed clonal transition and acquisition of resistance to treatment.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- [Rinsho ketsueki] The Japanese journal of clinical hematology
- 巻
- 65
- 号
- 2
- 開始ページ
- 63
- 終了ページ
- 68
- 出版年月
- 2024年
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.11406/rinketsu.65.63
- 共同研究・競争的資金等の研究課題
研究者
大保木 啓介
(オオボキ ケイスケ)