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論文
- タイトル
- タイトル（英）
- Structure of raft-model membrane by using the inverse contrast variation neutron scattering method
- 参照URL
- https://researchmap.jp/kasahara-kj/published_papers/46441734
- 著者
- 著者（英）
- Mitsuhiro Hirai,Harutaka Hirai,Masaharu Koizumi,Kohji Kasahara,Kohei Yuyama,Naoko Suzuki
- 担当区分
- 概要
- 概要（英）
- By means of the inverse contrast variation method in small-angle neutron scattering, we have studied the structure of a small unilamellar vesicle (SUV) composed of ganglioside, cholesterol and dipalmitoyl-phosphocholine. The SUV treated has a similar lipid composition as in a plasma membrane with microdomains, so-called rafts. The present results indicate an asymmetric distribution of lipid components within the bilayer of the vesicle, that is, a predominant distribution of ganglioside and cholesterol at the outer leaflet of the vesicle bilayer. The deviation from the linearity in a pseudo-Stuhrmannplot strongly suggests the presence of a large heterogeneity of lipid composition in a bilayer, namely a clustering of ganglioside and cholesterol molecules. This deviation is enhanced by temperature elevation, meaning that ganglioside-cholesterol clusters become larger with holding liquid-ordered (L-o) phase. (c) 2006 Elsevier B.V. All rights reserved.
- 出版者・発行元
- 出版者・発行元（英）
- ELSEVIER SCIENCE BV
- 誌名
- 誌名（英）
- PHYSICA B-CONDENSED MATTER
- 巻
- 385-86
- 号
- 開始ページ
- 868
- 終了ページ
- 870
- 出版年月
- 2006年11月
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 0921-4526
- DOI URL
- https://doi.org/10.1016/j.physb.2006.05.129
- 共同研究・競争的資金等の研究課題
研究者
笠原 浩二
(カサハラ コウジ)