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論文
- タイトル
- タイトル(英)
- Pathogenic Potential of Eomesodermin-Expressing T-Helper Cells in Neurodegenerative Diseases.
- 参照URL
- https://researchmap.jp/kimura_vision/published_papers/46883142
- 著者
- 著者(英)
- Tomomi Kanazawa,Wakiro Sato,Ben J E Raveney,Daiki Takewaki,Atsuko Kimura,Hiromi Yamaguchi,Yuma Yokoi,Reiko Saika,Yuji Takahashi,Tsuneo Fujita,Shinji Saiki,Akira Tamaoka,Shinji Oki,Takashi Yamamura
- 担当区分
- 概要
- 概要(英)
- Eomesodermin-expressing (Eomes+) T-helper (Th) cells show cytotoxic characteristics in secondary progressive multiple sclerosis. We found that Eomes+ Th cell frequency was increased in the peripheral blood of amyotrophic lateral sclerosis and Alzheimer's disease patients. Furthermore, granzyme B production by Th cells from such patients was high compared with controls. A high frequency of Eomes+ Th cells was observed in the initial (acutely progressive) stage of amyotrophic lateral sclerosis, and a positive correlation between Eomes+ Th cell frequency and cognitive decline was observed in Alzheimer's disease patients. Therefore, Eomes+ Th cells may be involved in the pathology of amyotrophic lateral sclerosis and Alzheimer's disease. ANN NEUROL 2024;95:1093-1098.
- 出版者・発行元
- 出版者・発行元(英)
- 誌名
- 誌名(英)
- Annals of neurology
- 巻
- 95
- 号
- 6
- 開始ページ
- 1093
- 終了ページ
- 1098
- 出版年月
- 2024年6月
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文(学術雑誌)
- ISSN
- DOI URL
- https://doi.org/10.1002/ana.26920
- 共同研究・競争的資金等の研究課題
研究者
木村 敦子
( )