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論文
- タイトル
- タイトル（英）
- Conventional magnetic resonance imaging key features for distinguishing pathologically confirmed corticobasal degeneration from its mimics: a retrospective analysis of the J-VAC study.
- 参照URL
- https://researchmap.jp/masatohasegawa/published_papers/47242569
- 著者
- 著者（英）
- Keita Sakurai,Aya M Tokumaru,Mari Yoshida,Yuko Saito,Koichi Wakabayashi,Takashi Komori,Masato Hasegawa,Takeshi Ikeuchi,Yuichi Hayashi,Takayoshi Shimohata,Shigeo Murayama,Yasushi Iwasaki,Toshiki Uchihara,Motoko Sakai,Ichiro Yabe,Satoshi Tanikawa,Hiroshi Takigawa,Tadashi Adachi,Ritsuko Hanajima,Harutoshi Fujimura,Kentaro Hayashi,Keizo Sugaya,Kazuko Hasegawa,Terunori Sano,Masaki Takao,Osamu Yokota,Tomoko Miki,Michio Kobayashi,Nobutaka Arai,Takuya Ohkubo,Takanori Yokota,Keiko Mori,Masumi Ito,Chiho Ishida,Jiro Idezuka,Yasuko Toyoshima,Masato Kanazawa,Masashi Aoki,Takafumi Hasegawa,Hirohisa Watanabe,Atsushi Hashizume,Hisayoshi Niwa,Keizo Yasui,Keita Ito,Yukihiko Washimi,Akatsuki Kubota,Tatsushi Toda,Kenji Nakashima,Ikuko Aiba
- 担当区分
- 概要
- 概要（英）
- PURPOSE: Due to the indistinguishable clinical features of corticobasal syndrome (CBS), the antemortem differentiation between corticobasal degeneration (CBD) and its mimics remains challenging. However, the utility of conventional magnetic resonance imaging (MRI) for the diagnosis of CBD has not been sufficiently evaluated. This study aimed to investigate the diagnostic performance of conventional MRI findings in differentiating pathologically confirmed CBD from its mimics. METHODS: Semiquantitative visual rating scales were employed to assess the degree and distribution of atrophy and asymmetry on conventional T1-weighted and T2-weighted images. Additionally, subcortical white matter hyperintensity (SWMH) on fluid-attenuated inversion recovery images were visually evaluated. RESULTS: In addition to 19 patients with CBD, 16 with CBD mimics (progressive supranuclear palsy (PSP): 9, Alzheimer's disease (AD): 4, dementia with Lewy bodies (DLB): 1, frontotemporal lobar degeneration with TAR DNA-binding protein of 43 kDa(FTLD-TDP): 1, and globular glial tauopathy (GGT): 1) were investigated. Compared with the CBD group, the PSP-CBS subgroup showed severe midbrain atrophy without SWMH. The non-PSP-CBS subgroup, comprising patients with AD, DLB, FTLD-TDP, and GGT, showed severe temporal atrophy with widespread asymmetry, especially in the temporal lobes. In addition to over half of the patients with CBD, two with FTLD-TDP and GGT showed SWMH, respectively. CONCLUSION: This study elucidates the distinct structural changes between the CBD and its mimics based on visual rating scales. The evaluation of atrophic distribution and SWMH may serve as imaging biomarkers of conventional MRI for detecting background pathologies.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Neuroradiology
- 巻
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2024年7月22日
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1007/s00234-024-03432-w
- 共同研究・競争的資金等の研究課題
研究者
Hasegawa Masato
( )