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論文
- タイトル
- タイトル（英）
- rs12411980 single-nucleotide polymorphism related to <i>PRTFDC1</i> expression is significantly associated with phantom tooth pain
- 参照URL
- https://researchmap.jp/kazutakaikeda/published_papers/47319480
- 著者
- 著者（英）
- Jun Araida,Seii Ohka,Moe Soeda,Daisuke Nishizawa,Junko Hasegawa,Kyoko Nakayama,Yuko Ebata,Yasukazu Ogai,Ken-ichi Fukuda,Kazutaka Ikeda
- 担当区分
- 概要
- 概要（英）
- Phantom tooth pain (PTP) is one type of non-odontogenic neuropathic toothache, which rarely occurs after appropriate pulpectomy or tooth extraction. The cause of PTP is unknown. We investigated pain-related genetic factors that are associated with PTP. Four pain-associated genes, including G protein-coupled receptor 158 ( GPR158) and phosphoribosyl transferase domain containing 1 ( PRTFDC1), are adjacent to each other on the human genome. Some of these four genes or their genomic region may be related to PTP. We statistically analyzed associations between single-nucleotide polymorphisms (SNPs) in the genomic region and PTP in patients with PTP (PTP group), other orofacial pain (OFP group), and healthy control subjects. We then performed a database search of expression quantitative trait loci (eQTLs). For the seven SNPs that were significantly associated with PTP even after Bonferroni correction, we focused on the rs12411980 tag SNP ( P = 9.42 × 10<sup>-4</sup>). Statistical analyses of the PTP group and healthy subject groups (group labels: NOC and TD) revealed that the rate of the GG genotype of the rs12411980 SNP was significantly higher in the PTP group than in the healthy subject groups (PTP group vs. NOC group: P = 2.92 × 10<sup>-4</sup>, PTP group vs. TD group: P = 5.46 × 10<sup>-4</sup>; percentage of GG: 30% in PTP group, 12% in NOC group, 11% in TD group). These results suggest that the GG genotype of the rs12411980 SNP is more susceptible to PTP. The rs2765697 SNP that is in strong linkage disequilibrium with the rs12411980 SNP is an eQTL that is associated with higher PRTFDC1 expression in the minor allele homozygotes in the healthy subject groups of the rs2765697 SNP. Thus, PRTFDC1 expression similarly increases in the minor allele homozygotes (GG genotype) in the healthy subject groups of the rs12411980 SNP, which would lead to greater susceptibility to PTP.
- 出版者・発行元
- 出版者・発行元（英）
- SAGE Publications
- 誌名
- 誌名（英）
- Molecular Pain
- 巻
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2024年8月2日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 1744-8069
- DOI URL
- https://doi.org/10.1177/17448069241272215
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