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論文
- タイトル
- タイトル（英）
- Future spinal reflex is embedded in primary motor cortex output.
- 参照URL
- https://researchmap.jp/miki_K/published_papers/48792210
- 著者
- 著者（英）
- Tatsuya Umeda,Osamu Yokoyama,Michiaki Suzuki,Miki Kaneshige,Tadashi Isa,Yukio Nishimura
- 担当区分
- 概要
- 概要（英）
- Mammals can execute intended limb movements despite the fact that spinal reflexes involuntarily modulate muscle activity. To generate appropriate muscle activity, the cortical descending motor output must coordinate with spinal reflexes, yet the underlying neural mechanism remains unclear. We simultaneously recorded activities in motor-related cortical areas, afferent neurons, and forelimb muscles of monkeys performing reaching movements. Motor-related cortical areas, predominantly primary motor cortex (M1), encode subsequent afferent activities attributed to forelimb movement. M1 also encodes a subcomponent of muscle activity evoked by these afferent activities, corresponding to spinal reflexes. Furthermore, selective disruption of the afferent pathway specifically reduced this subcomponent of muscle activity, suggesting that M1 output drives muscle activity not only through direct descending pathways but also through the "transafferent" pathway composed of descending plus subsequent spinal reflex pathways. Thus, M1 provides optimal motor output based on an internal forward model that prospectively computes future spinal reflexes.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Science advances
- 巻
- 10
- 号
- 51
- 開始ページ
- eadq4194
- 終了ページ
- 出版年月
- 2024年12月20日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1126/sciadv.adq4194
- 共同研究・競争的資金等の研究課題