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論文
- タイトル
- Temporal and Potential Predictive Relationships between Sleep Spindle Density and Spike-and-Wave Discharges
- タイトル（英）
- Temporal and Potential Predictive Relationships between Sleep Spindle Density and Spike-and-Wave Discharges
- 参照URL
- https://researchmap.jp/akiyo/published_papers/48308677
- 著者
- Manal S. Abdelaal,Tomonobu Kato,Akiyo Natsubori,Kenji F. Tanaka
- 著者（英）
- Manal S. Abdelaal,Tomonobu Kato,Akiyo Natsubori,Kenji F. Tanaka
- 担当区分
- 概要
- 概要（英）
- Spike-and-wave discharges (SWDs) and sleep spindles are characteristic electroencephalographic (EEG) hallmarks of absence seizures and nonrapid eye movement sleep, respectively. They are commonly generated by the cortico–thalamo–cortical network including the thalamic reticular nucleus (TRN). It has been reported that SWD development is accompanied by a decrease in sleep spindle density in absence seizure patients and animal models. However, whether the decrease in sleep spindle density precedes, coincides with, or follows, the SWD development remains unknown. To clarify this, we exploitedPvalb-tetracycline transactivator (tTA)::tetO-ArchT (PV-ArchT) double-transgenic mouse, which can induce an absence seizure phenotype in a time-controllable manner by expressing ArchT in PV neurons of the TRN. In these mice, EEG recordings demonstrated that a decrease in sleep spindle density occurred 1 week before the onset of typical SWDs, with the expression of ArchT. To confirm such temporal relationship observed in these genetic model mice, we used a gamma-butyrolactone (GBL) pharmacological model of SWDs. Prior to GBL administration, we administered caffeine to wild-type mice for 3 consecutive days to induce a decrease in sleep spindle density. We then administered low-dose GBL, which cannot induce SWDs in normally conditioned mice but led to the occurrence of SWDs in caffeine-conditioned mice. These findings indicate a temporal relationship in which the decrease in sleep spindle density consistently precedes SWD development. Furthermore, the decrease in sleep spindle activity may have a role in facilitating the development of SWDs. Our findings suggest that sleep spindle reductions could serve as early indicators of seizure susceptibility.
- 出版者・発行元
- 出版者・発行元（英）
- Society for Neuroscience
- 誌名
- eNeuro
- 誌名（英）
- eNeuro
- 巻
- 11
- 号
- 9
- 開始ページ
- ENEURO.0058
- 終了ページ
- 24.2024
- 出版年月
- 2024年9月
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1523/eneuro.0058-24.2024
- 共同研究・競争的資金等の研究課題
研究者
夏堀 晃世
( )