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論文
- タイトル
- タイトル（英）
- Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds.
- 参照URL
- https://researchmap.jp/masamisuzukake/published_papers/48207872
- 著者
- 著者（英）
- Jennifer A Macdonald,John L Chen,Masami Masuda-Suzukake,Manuel Schweighauser,Zane Jaunmuktane,Thomas Warner,Janice L Holton,Annabelle Grossman,Richard Berks,Isabelle Lavenir,Michel Goedert
- 担当区分
- 概要
- 概要（英）
- Peripheral administration (oral, intranasal, intraperitoneal, intravenous) of assembled A53T α-synuclein induced synucleinopathy in heterozygous mice transgenic for human mutant A53T α-synuclein (line M83). The same was the case when cerebellar extracts from a case of multiple system atrophy with type II α-synuclein filaments were administered intraperitoneally, intravenously or intramuscularly. We observed abundant immunoreactivity for pS129 α-synuclein in nerve cells and severe motor impairment, resulting in hindlimb paralysis and shortened lifespan. Filaments immunoreactive for pS129 α-synuclein were in evidence. A 70% loss of motor neurons was present five months after an intraperitoneal injection of assembled A53T α-synuclein or cerebellar extract with type II α-synuclein filaments from an individual with a neuropathologically confirmed diagnosis of multiple system atrophy. Microglial cells changed from a predominantly ramified to a dystrophic appearance. Taken together, these findings establish a close relationship between the formation of α-synuclein inclusions in nerve cells and neurodegeneration, accompanied by a shift in microglial cell morphology. Propagation of α-synuclein inclusions depended on the characteristics of both seeds and transgenically expressed protein.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Acta neuropathologica communications
- 巻
- 9
- 号
- 1
- 開始ページ
- 189
- 終了ページ
- 189
- 出版年月
- 2021年11月24日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1186/s40478-021-01291-7
- 共同研究・競争的資金等の研究課題
研究者
鈴掛 雅美
(スズカケ マサミ)