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論文
- タイトル
- タイトル（英）
- Effect of <scp>A118G</scp> (rs1799971) single‐nucleotide polymorphism of the μ‐opioid receptor <i>OPRM1</i> gene on intraoperative remifentanil requirements in Japanese women undergoing laparoscopic gynecological surgery
- 参照URL
- https://researchmap.jp/daisuke_nishizawa/published_papers/48104744
- 著者
- 著者（英）
- Ruying Zou,Daisuke Nishizawa,Rie Inoue,Junko Hasegawa,Yuko Ebata,Kyoko Nakayama,Atsuko Hara,Hiroyuki Sumikura,Mari Kitade,Masakazu Hayashida,Kazutaka Ikeda,Izumi Kawagoe
- 担当区分
- 概要
- 概要（英）
- Abstract Aim Abundant data are available on the effect of the A118G (rs1799971) single‐nucleotide polymorphism (SNP) of the μ‐opioid receptor OPRM1 gene on morphine and fentanyl requirements for pain control. However, data on the effect of this SNP on intraoperative remifentanil requirements remain limited. We investigated the effect of this SNP on intraoperative remifentanil requirements. Methods We investigated 333 Japanese women, aged 21–69 years, who underwent laparoscopic gynecological surgery for benign gynecological disease under total intravenous anesthesia at Juntendo University Hospital. Average infusion rates of propofol and remifentanil during anesthesia and the average bispectral index (BIS) during surgery were recorded. Associations among genotypes of the A118G and phenotypes were examined with the Mann–Whitney U test. Results The average propofol infusion rate was not different between patients with different genotypes. The average remifentanil infusion rate was significantly higher in patients with the AG or GG genotype than the AA genotype (p = 0.028). The average intraoperative BIS was significantly higher in patients with the GG genotype than the AA or AG genotype (p = 0.039). Conclusions The G allele of the A118G SNP was associated with higher intraoperative remifentanil requirements and higher intraoperative BIS values but was not associated with propofol requirements. Given that remifentanil and propofol act synergistically on the BIS, these results suggest that the G allele of the A118G SNP is associated with lower effects of remifentanil in achieving adequate intraoperative analgesia and in potentiating the sedative effect of propofol on the BIS.
- 出版者・発行元
- 出版者・発行元（英）
- Wiley
- 誌名
- 誌名（英）
- Neuropsychopharmacology Reports
- 巻
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2024年8月2日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 2574-173X
- DOI URL
- https://doi.org/10.1002/npr2.12468
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