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論文
- タイトル
- Anti-amyloid beta therapy resolves stroke recovery impairment caused by Alzheimer's disease
- タイトル（英）
- Anti-amyloid beta therapy resolves stroke recovery impairment caused by Alzheimer's disease
- 参照URL
- https://researchmap.jp/hippocampus-sak/published_papers/50189295
- 著者
- 著者（英）
- Seiichiro Sakai,Kento Otani,Jun Tsuyama,Yuichiro Hara,Ko Abe,Teppei Shimamura,Ito Kawakami,Takashi Komori,Hideya Kawaji,Koji Hase,Takashi Saito,Takashi Shichita
- 担当区分
- 筆頭著者
- 概要
- 概要（英）
- Stroke and dementia are common comorbidities and a growing concern causing disability in aging societies worldwide. Although anti-amyloid beta (anti-Aβ) antibodies have recently been anticipated to relieve preclinical Alzheimer's disease pathology, we discovered that post-stroke administration of anti-Aβ antibodies restored neural repair for stroke recovery impeded by cerebral Aβ accumulation. Neuronal recovery-associated gene expression for stroke recovery was considerably impaired even by slight Aβ accumulation in murine and human brain. Slight Aβ accumulation had less impact on neurons without stroke but caused a unique myeloid immunity after an ischemic stroke that enhanced the inflammatory cascades impeding neural repair for stroke recovery. Aducanumab administration after ischemic stroke prevented formation of this malignant myeloid immunity, resolving the impairment of post-stroke neural repair caused by cerebral Aβ accumulation. Thus, our study has revealed the ability of anti-Aβ therapies to restore functional recovery after a stroke with cerebral Aβ accumulation.
- 出版者・発行元
- 出版者・発行元（英）
- Cold Spring Harbor Laboratory
- 誌名
- bioRxiv
- 誌名（英）
- 巻
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2025年5月15日
- 査読の有無
- 招待の有無
- 掲載種別
- ISSN
- DOI URL
- https://doi.org/10.1101/2025.05.12.653388
- 共同研究・競争的資金等の研究課題
研究者
酒井 誠一郎
(サカイ セイイチロウ)