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論文
- タイトル
- タイトル（英）
- Curcumin promotes AApoAII amyloidosis and peroxisome proliferation in mice by activating the PPARα signaling pathway
- 参照URL
- https://researchmap.jp/alz42/published_papers/32800667
- 著者
- 著者（英）
- Jian Dai,Ying Li,Fuyuki Kametani,Xiaoran Cui,Yuichi Igarashi,Jia Huo,Hiroki Miyahara,Masayuki Mori,Keiichi Higuchi
- 担当区分
- 概要
- 概要（英）
- Curcumin is a polyphenol compound that exhibits multiple physiological activities. To elucidate the mechanisms by which curcumin affects systemic amyloidosis, we investigated amyloid deposition and molecular changes in a mouse model of amyloid apolipoprotein A-II (AApoAII) amyloidosis, in which mice were fed a curcumin-supplemented diet. Curcumin supplementation for 12 weeks significantly increased AApoAII amyloid deposition relative to controls, especially in the liver and spleen. Liver weights and plasma ApoA-II and high-density lipoprotein concentrations were significantly elevated in curcumin-supplemented groups. RNA-sequence analysis revealed that curcumin intake affected hepatic lipid metabolism via the peroxisome proliferator-activated receptor (PPAR) pathway, especially PPARα activation, resulting in increased
Apoa2 mRNA expression. The increase in liver weights was due to activation of PPARα and peroxisome proliferation. Taken together, these results demonstrate that curcumin is a PPARα activator and may affect expression levels of proteins involved in amyloid deposition to influence amyloidosis and metabolism in a complex manner. - 出版者・発行元
- 出版者・発行元（英）
- eLife Sciences Publications, Ltd
- 誌名
- 誌名（英）
- eLife
- 巻
- 10
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2021年1月26日
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.7554/elife.63538
- 共同研究・競争的資金等の研究課題
研究者
亀谷 富由樹
(カメタニ フユキ)