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論文
- タイトル
- タイトル（英）
- Isoform-Selective NFAT Inhibitor: Potential Usefulness and Development.
- 参照URL
- https://researchmap.jp/tig33449462/published_papers/32860798
- 著者
- 著者（英）
- Noriko Kitamura,Osamu Kaminuma
- 担当区分
- 概要
- 概要（英）
- Nuclear factor of activated T cells (NFAT), which is the pharmacological target of immunosuppressants cyclosporine and tacrolimus, has been shown to play an important role not only in T cells (immune system), from which their name is derived, but also in many biological events. Therefore, functional and/or structural abnormalities of NFAT are linked to the pathogenesis of diseases in various organs. The NFAT protein family consists of five isoforms, and each isoform performs diverse functions and has unique expression patterns in the target tissues. This diversity has made it difficult to obtain ideal pharmacological output for immunosuppressants that inhibit the activity of almost all NFAT family members, causing serious and wide-ranging side effects. Moreover, it remains unclear whether isoform-selective NFAT regulation can be achieved by targeting the structural differences among NFAT isoforms and whether this strategy can lead to the development of better drugs than the existing ones. This review summarizes the role of the NFAT family members in biological events, including the development of various diseases, as well as the usefulness of and problems associated with NFAT-targeting therapies, including those dependent on current immunosuppressants. Finally, we propose a novel therapeutic strategy based on the molecular mechanisms that enable selective regulation of specific NFAT isoforms.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- International journal of molecular sciences
- 巻
- 22
- 号
- 5
- 開始ページ
- 終了ページ
- 出版年月
- 2021年3月8日
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.3390/ijms22052725
- 共同研究・競争的資金等の研究課題
研究者
北村 紀子
(キタムラ ノリコ)