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MISC
- タイトル
- タイトル（英）
- Acetylcholine releases of mesopontine PGO-on cells in the lateral geniculate nucleus in sleep-waking cycle and serotonergic regulation
- 参照URL
- https://researchmap.jp/SleepLab/misc/28179267
- 著者
- 著者（英）
- T Kodama,Y Honda
- 担当区分
- 概要
- 概要（英）
- 1. Five adult cats were prepared with standard sleep-recording electrodes, microinjection cannulae in the bilateral mesopontine tegmentum X area and cannulae for microdialysis probes in the LGN. 2. Dialysates were collected at 5 min intervals during SWS, REM sleep and wakefulness, and during pre- and post-stimulation periods of 5MeODMT microinjection in the bilateral mesopontine tegmentum of freely moving cats. 3. A REM sleep-specific increase of ACh release was observed in the LGN, but not out of the LGN. 4. ACh release was depressed up to 33% by bilateral 5MeODMT microinjection in the mesopontine tegmentum where the microinjection of carbachol also depressed ACh in the LGN probably by stimulating the auto receptor. 5. Our observations indicate that PGO-on neurons of mesopontine tegmentum release more ACh in the LGN during REM sleep by burst discharge than during wakefulness and SWS, and that presumptive cholinergic PGO-on cells are regulated by serotonergic inputs.
- 出版者・発行元
- 出版者・発行元（英）
- PERGAMON-ELSEVIER SCIENCE LTD
- 誌名
- 誌名（英）
- PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- 巻
- 20
- 号
- 7
- 開始ページ
- 1213
- 終了ページ
- 1227
- 出版年月
- 1996年10月
- 査読の有無
- 招待の有無
- 掲載種別
- 書評論文,書評,文献紹介等
- ISSN
- 0278-5846
- DOI URL
- 共同研究・競争的資金等の研究課題
研究者
児玉 亨
( )