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論文
- タイトル
- タイトル（英）
- Oral Administration of Methylphenidate (Ritalin) Affects Dopamine Release Differentially Between the Prefrontal Cortex and Striatum: A Microdialysis Study in the Monkey.
- 参照URL
- https://researchmap.jp/SleepLab/published_papers/27523233
- 著者
- 著者（英）
- Tohru Kodama,Takashi Kojima,Yoshiko Honda,Takayuki Hosokawa,Ken-Ichiro Tsutsui,Masataka Watanabe
- 担当区分
- 概要
- 概要（英）
- Methylphenidate (MPH; trade name Ritalin) is a widely used drug for the treatment of attention deficit hyperactivity disorder (ADHD) and is often used as a cognitive enhancer. Because MPH increases dopamine (DA) release by blocking the DA transporter in the human striatum, MPH is supposed to work on attention and cognition through a DA increase in the striatum. However, ADHD patients show impaired prefrontal cortex (PFC) function and MPH administration is associated with increased neural activity in the PFC. Although MPH is indicated to increase DA release in the rat PFC, there has been no study to examine MPH-induced DA changes in the human PFC because of technical difficulties associated with the low level of PFC DA receptors. Using the microdialysis technique, we examined the effects of oral administration of MPH on DA release in both the PFC and striatum in the monkey. We also tested the effect of MPH on cognitive task performance. As in human studies, in the striatum, both high and low doses of MPH induced consistent increases in DA release ∼30 min after their administrations. In the PFC, a consistent increase in DA release was observed 1 h after a high dose, but not low doses, of MPH. Low doses of MPH improved cognitive task performance, but a high dose of MPH made the monkey drowsy. Therefore, low-dose MPH-induced cognitive enhancement is supported by striatum DA increase.SIGNIFICANCE STATEMENT Methylphenidate (MPH) is a widely used drug for the treatment of attention deficit hyperactivity disorder and is often used as a cognitive enhancer. Although human positron emission tomography studies suggest that MPH works on attention and cognition through dopamine (DA) changes in the striatum, there has been no study to examine MPH-induced DA changes in the human prefrontal cortex (PFC). Using the microdialysis technique in monkeys, we found, for the first time, that low doses of MPH consistently increased DA release in the striatum but did not in the PFC. Cognitive enhancement effects of low doses of MPH are supposed to be supported by the striatum DA increase.
- 出版者・発行元
- 出版者・発行元（英）
- SOC NEUROSCIENCE
- 誌名
- 誌名（英）
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- 巻
- 37
- 号
- 9
- 開始ページ
- 2387
- 終了ページ
- 2394
- 出版年月
- 2017年3月1日
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 0270-6474
- DOI URL
- https://doi.org/10.1523/JNEUROSCI.2155-16.2017
- 共同研究・競争的資金等の研究課題
研究者
児玉 亨
( )