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論文
- タイトル
- タイトル（英）
- Dopamine and glutamate release in the anterior default system during rest: A monkey microdialysis study
- 参照URL
- https://researchmap.jp/SleepLab/published_papers/28278099
- 著者
- 著者（英）
- Tohru Kodama,Kazuo Hikosaka,Yoshiko Honda,Takashi Kojima,Ken-ichiro Tsutsui,Masataka Watanabe
- 担当区分
- 概要
- 概要（英）
- Human neuroimaging studies have demonstrated the presence of a default system in the brain, which shows a default mode of brain activity, i.e., greater activity during rest than during an attentiondemanding cognitive task. Our previous study on monkeys has revealed a default mode of brain activity in medial cortical areas. We have observed an increase in dopamine (DA) release during a working memory (WM) task compared with that during rest in the monkey lateral prefrontal cortex (LPFC). However, no previous study has examined DA release related to the default mode of brain activity. We used a microdialysis technique to investigate changes in DA release in the medial prefrontal cortex (MPFC), which constitutes the anterior default system, during the WM task and rest. Because DA and glutamate (Glu) release in the LPFC is interrelated, we also examined Glu release in the MPFC. We observed a significant increase in DA release, but no significant change in Glu release during rest compared with that during the WM task. We also observed an inhibitory relationship between the two transmitters in the MPFC. Considering that human default brain activity is related to internal thought processes and increased DA release in the LPFC plays an important role in executive control, increase in DA release during rest in the monkey anterior default system may be related to some form of internal thought process. (C) 2015 Elsevier B.V. All rights reserved.
- 出版者・発行元
- 出版者・発行元（英）
- ELSEVIER SCIENCE BV
- 誌名
- 誌名（英）
- BEHAVIOURAL BRAIN RESEARCH
- 巻
- 294
- 号
- 開始ページ
- 194
- 終了ページ
- 197
- 出版年月
- 2015年11月
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 0166-4328
- DOI URL
- https://doi.org/10.1016/j.bbr.2015.08.013
- 共同研究・競争的資金等の研究課題
研究者
児玉 亨
( )