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論文
- タイトル
- タイトル（英）
- Cortical acetylcholine release is lateralized during asymmetrical slow-wave sleep in Northern fur seals
- 参照URL
- https://researchmap.jp/SleepLab/published_papers/1028009
- 著者
- 著者（英）
- Jennifer L. Lapierre,Peter O. Kosenko,Oleg I. Lyamin,Tohru Kodama,Lev M. Mukhametov,Jerome M. Siegel
- 担当区分
- 概要
- 概要（英）
- Fur seals are unique in that they display both bilateral slow-wave sleep (BSWS), as seen in all terrestrial mammals, and slow-wave sleep with interhemispheric electroencephalogram ( EEG) asymmetry, resembling the unihemispheric slow waves of cetaceans. Little is known about the underlying mechanisms of this phenomenon, which is also termed asymmetrical slow wave sleep (ASWS). However, we may begin to understand the expression of ASWS by studying the neurotransmitter systems thought to be involved in the generation and maintenance of sleep-wake states in terrestrial mammals. We examined bilaterally the release of cortical acetylcholine (ACh), a neurotransmitter implicated in the regulation of cortical EEG and behavioral arousal, across the sleep-wake cycle in four juvenile northern fur seals (Callorhinus ursinus). In vivo microdialysis and high-performance liquid chromatography coupled with electrochemical detection were used to measure cortical ACh levels during polygraphically defined behavioral states. Cortical ACh release was state-dependent, showing maximal release during active waking (AW), similar levels during quiet waking (QW), and rapid eye movement ( REM) sleep, and minimal release during BSWS. When compared with BSWS, cortical ACh levels increased similar to 300% during AW, and similar to 200% during QW and REM sleep. During these bilaterally symmetrical EEG states, ACh was synchronously released from both hemispheres. However, during ASWS, ACh release was lateralized with greater release in the hemisphere displaying lower voltage activity, at levels approximating those seen in QW. These findings demonstrate that cortical ACh release is tightly linked to hemispheric EEG activation.
- 出版者・発行元
- 出版者・発行元（英）
- SOC NEUROSCIENCE
- 誌名
- 誌名（英）
- JOURNAL OF NEUROSCIENCE
- 巻
- 27
- 号
- 44
- 開始ページ
- 11999
- 終了ページ
- 12006
- 出版年月
- 2007年10月
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 0270-6474
- DOI URL
- https://doi.org/10.1523/JNEUROSCI.2968-07.2007
- 共同研究・競争的資金等の研究課題
研究者
児玉 亨
( )