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論文
- タイトル
- Nucleus accumbens as the motivation center is essential for functional recovery after spinal cord injury（意欲中枢側坐核が脊髄損傷後の機能回復を支える神経基盤）
- タイトル（英）
- Nucleus accumbens as the motivation center is essential for functional recovery after spinal cord injury
- 参照URL
- https://researchmap.jp/michiaki_suzuki/published_papers/36216883
- 著者
- 鈴木 迪諒,西村 幸男
- 著者（英）
- SUZUKI Michiaki,NISHIMURA Yukio
- 担当区分
- 概要
- Dexterous finger movements depend largely on the corticospinal tract (CST) in higher primates. Following a partial spinal cord injury (SCI) including the CST at the mid-cervical segment in non-human primates, dexterous finger movements impaired immediately, but recover within 1-3 months by intensive rehabilitation. Plastic changes in activity of the primary motor cortex (M1), premotor cortex (PM), and spinal circuits associated with recovery of dexterous finger movements. However, the contribution of up-stream of the motor cortices to recovery after a partial SCI remains unclear. Recently, we demonstrated that the nucleus accumbens (NAcc), which is known as a key node for processing motivation and reward, facilitates activity of the M1 and is directly involved in the control of finger movements in the early recovery stage after a partial SCI. We further clarified that the NAcc is essential for recover of dexterous finger movements after a partial SCI. Although the NAcc is not thought to be involved directly in motor control, our findings demonstrated that the NAcc has a functional role for motor control after a partial SCI. Furthermore, neuroimaging study revealed that reorganization of the NAcc-motor networks occurs after a partial SCI. Our findings suggest that the NAcc is the key node of the cortical reorganization required for functional recovery of finger dexterity.
- 概要（英）
- Dexterous finger movements depend largely on the corticospinal tract (CST) in higher primates. Following a partial spinal cord injury (SCI) including the CST at the mid-cervical segment in non-human primates, dexterous finger movements impaired immediately, but recover within 1-3 months by intensive rehabilitation. Plastic changes in activity of the primary motor cortex (M1), premotor cortex (PM), and spinal circuits associated with recovery of dexterous finger movements. However, the contribution of up-stream of the motor cortices to recovery after a partial SCI remains unclear. Recently, we demonstrated that the nucleus accumbens (NAcc), which is known as a key node for processing motivation and reward, facilitates activity of the M1 and is directly involved in the control of finger movements in the early recovery stage after a partial SCI. We further clarified that the NAcc is essential for recover of dexterous finger movements after a partial SCI. Although the NAcc is not thought to be involved directly in motor control, our findings demonstrated that the NAcc has a functional role for motor control after a partial SCI. Furthermore, neuroimaging study revealed that reorganization of the NAcc-motor networks occurs after a partial SCI. Our findings suggest that the NAcc is the key node of the cortical reorganization required for functional recovery of finger dexterity.
- 出版者・発行元
- 脳機能とリハビリテーション研究会
- 出版者・発行元（英）
- Japanese Society for Brain Function and Rehabilitation
- 誌名
- Journal of Rehabilitation Neurosciences
- 誌名（英）
- Journal of Rehabilitation Neurosciences
- 巻
- 21
- 号
- 開始ページ
- 23
- 終了ページ
- 28
- 出版年月
- 2021年
- 査読の有無
- 招待の有無
- 掲載種別
- ISSN
- 2434-2629
- DOI URL
- https://doi.org/10.24799/jrehabilneurosci.201115
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