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論文
- タイトル
- タイトル(英)
- Molecular encoding and synaptic decoding of context during salt chemotaxis in C. elegans
- 参照URL
- https://researchmap.jp/SHiroki_researchmap/published_papers/39748429
- 著者
- 著者(英)
- Shingo Hiroki,Hikari Yoshitane,Hinako Mitsui,Hirofumi Sato,Chie Umatani,Shinji Kanda,Yoshitaka Fukada,Yuichi Iino
- 担当区分
- 概要
- 概要(英)
- Abstract Animals navigate toward favorable locations using various environmental cues. However, the mechanism of how the goal information is encoded and decoded to generate migration toward the appropriate direction has not been clarified. Here, we describe the mechanism of migration towards a learned concentration of NaCl in Caenorhabditis elegans. In the salt-sensing neuron ASER, the difference between the experienced and currently perceived NaCl concentration is encoded as phosphorylation at Ser65 of UNC-64/Syntaxin 1 A through the protein kinase C(PKC-1) signaling pathway. The phosphorylation affects basal glutamate transmission from ASER, inducing the reversal of the postsynaptic response of reorientation-initiating neurons (i.e., from inhibitory to excitatory), guiding the animals toward the experienced concentration. This process, the decoding of the context, is achieved through the differential sensitivity of postsynaptic excitatory and inhibitory receptors. Our results reveal the mechanism of migration based on the synaptic plasticity that conceptually differs from the classical ones.
- 出版者・発行元
- 出版者・発行元(英)
- Springer Science and Business Media LLC
- 誌名
- 誌名(英)
- Nature Communications
- 巻
- 13
- 号
- 1
- 開始ページ
- 終了ページ
- 出版年月
- 2022年12月
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文(学術雑誌)
- ISSN
- DOI URL
- https://doi.org/10.1038/s41467-022-30279-7
- 共同研究・競争的資金等の研究課題
研究者
吉種 光
(ヨシタネ ヒカリ)