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論文
- タイトル
- タイトル（英）
- Plasma unconjugated bile acids as novel biomarker for schizophrenia.
- 参照URL
- https://researchmap.jp/masanariitokawa/published_papers/40341496
- 著者
- 著者（英）
- Shin Koike,Yusuke Miyaji,Kazuhiro Suzuki,Mitsuhiro Miyashita,Masanari Itokawa,Makoto Arai,Yuki Ogasawara
- 担当区分
- 概要
- 概要（英）
- In this study, we measured conjugated and unconjugated free bile acids (BAs) in plasma from patients with schizophrenia and healthy subjects to examine the possibility of BA as a biomarker for schizophrenia. Although the levels of each BA conjugate showed no significant differences, significant differences for three unconjugated bile acids were observed in the plasma between patients with schizophrenia and healthy subjects. Additionally, a more than three times difference between patients and healthy subjects was observed in the mean value of the total concentrations of primary BAs. These results indicate that cholic acid and chenodeoxycholic acid levels in plasma may be novel diagnostic markers for a sub-population of patients with schizophrenia. Thus, future studies should elucidate the relationship between this increase in BA levels and the pathology of schizophrenia and verify the potential of unconjugated BA in plasma as biomarkers for schizophrenia.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Biochemical and biophysical research communications
- 巻
- 634
- 号
- 開始ページ
- 70
- 終了ページ
- 74
- 出版年月
- 2022年10月4日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1016/j.bbrc.2022.09.110
- 共同研究・競争的資金等の研究課題