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論文
タイトル
タイトル(英)
Temporal dynamics of the sensorimotor convergence underlying voluntary limb movement
参照URL
https://researchmap.jp/kore2460/published_papers/40557391
著者
著者(英)
Tatsuya Umeda,Tadashi Isa,Yukio Nishimura
概要
概要(英)
Descending motor drive and somatosensory feedback play important roles in modulating muscle activity. Numerous studies have characterized the organization of neuronal connectivity in which descending motor pathways and somatosensory afferents converge on spinal motor neurons as a final common pathway. However, how inputs from these two pathways are integrated into spinal motor neurons to generate muscle activity during actual motor behavior is unknown. Here, we simultaneously recorded activity in the motor cortices (MCx), somatosensory afferent neurons, and forelimb muscles in monkeys performing reaching and grasping movements. We constructed a linear model to explain the instantaneous muscle activity using the activity of MCx (descending input) and peripheral afferents (afferent input). Decomposition of the reconstructed muscle activity into each subcomponent indicated that muscle activity before movement onset could first be explained by descending input from mainly the primary motor cortex and muscle activity after movement onset by both descending and afferent inputs. Descending input had a facilitative effect on all muscles, whereas afferent input had a facilitative or suppressive effect on each muscle. Such antagonistic effects of afferent input can be explained by reciprocal effects of the spinal reflex. These results suggest that descending input contributes to the initiation of limb movement, and this initial movement subsequently affects muscle activity via the spinal reflex in conjunction with the continuous descending input. Thus, spinal motor neurons are subjected to temporally organized modulation by direct activation through the descending pathway and the lagged action of the spinal reflex during voluntary limb movement.
出版者・発行元
出版者・発行元(英)
Proceedings of the National Academy of Sciences
誌名
誌名(英)
Proceedings of the National Academy of Sciences
119
48
開始ページ
終了ページ
出版年月
2022年11月29日
査読の有無
招待の有無
掲載種別
研究論文(学術雑誌)
ISSN
0027-8424
DOI URL
https://doi.org/10.1073/pnas.2208353119
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研究者