※ をクリックすると外部の論文のサイトが開きます。
論文
- タイトル
- タイトル（英）
- Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy.
- 参照URL
- https://researchmap.jp/takayukiharada/published_papers/40766668
- 著者
- 著者（英）
- Youichi Shinozaki,Alex Leung,Kazuhiko Namekata,Sei Saitoh,Huy Bang Nguyen,Akiko Takeda,Yosuke Danjo,Yosuke M Morizawa,Eiji Shigetomi,Fumikazu Sano,Nozomu Yoshioka,Hirohide Takebayashi,Nobuhiko Ohno,Takahiro Segawa,Kunio Miyake,Kenji Kashiwagi,Takayuki Harada,Shin-Ichi Ohnuma,Schuichi Koizumi
- 担当区分
- 概要
- 概要（英）
- Astrocyte abnormalities have received great attention for their association with various diseases in the brain but not so much in the eye. Recent independent genome-wide association studies of glaucoma, optic neuropathy characterized by retinal ganglion cell (RGC) degeneration, and vision loss found that single-nucleotide polymorphisms near the ABCA1 locus were common risk factors. Here, we show that Abca1 loss in retinal astrocytes causes glaucoma-like optic neuropathy in aged mice. ABCA1 was highly expressed in retinal astrocytes in mice. Thus, we generated macroglia-specific Abca1-deficient mice (Glia-KO) and found that aged Glia-KO mice had RGC degeneration and ocular dysfunction without affected intraocular pressure, a conventional risk factor for glaucoma. Single-cell RNA sequencing revealed that Abca1 deficiency in aged Glia-KO mice caused astrocyte-triggered inflammation and increased the susceptibility of certain RGC clusters to excitotoxicity. Together, astrocytes play a pivotal role in eye diseases, and loss of ABCA1 in astrocytes causes glaucoma-like neuropathy.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Science advances
- 巻
- 8
- 号
- 44
- 開始ページ
- eabq1081
- 終了ページ
- 出版年月
- 2022年11月4日
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1126/sciadv.abq1081
- 共同研究・競争的資金等の研究課題