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論文
- タイトル
- タイトル（英）
- Safety and real-world efficacy of lemborexant in the treatment of comorbid insomnia.
- 参照URL
- https://researchmap.jp/Yoshikawa_A/published_papers/42128189
- 著者
- 著者（英）
- Narimasa Katsuta,Keitaro Takahashi,Yui Kurosawa,Akane Yoshikawa,Yoshihide Takeshita,Yoshihiro Uchida,Seita Yasuda,Chihiro Kakiuchi,Masanobu Ito,Tadafumi Kato
- 担当区分
- 概要
- 概要（英）
- AIM: To investigate the real-world effectiveness and safety of lemborexan for treating comorbid insomnia associated with other psychiatric disorders, and whether lemborexant helps reduce the dose of benzodiazepines (BZs). METHODS: This retrospective observational study was conducted on outpatients and inpatients treated by physicians of Juntendo University Hospital Mental Clinic between April 2020 and December 2021. RESULTS: Data of 649 patients who were treated with lemborexant were eventually enrolled. About 64.5% of patients were classified as the responder group. Response rates of ≥60% were recorded for most psychiatric disorders. Upon administration of lemborexant, diazepam-equivalent dose of BZs had been significantly reduced in participants (3.7 ± 8.2 vs. 2.9 ± 7.9, p < 0.001). The results of logistic regression analysis showed that outpatient (odds ratios: 2.310; 95% confidence interval [CI]: 1.32-4.05), shorter duration of BZ use (<1 year) (odds ratios: 1.512; 95% CI: 1.02-2.25), no adverse events (odds ratios: 10.369; 95% CI: 6.13-17.54), larger reduction of diazepam-equivalent dose of BZs upon introducing lemborexant prescription (odds ratios: 1.150; 95% CI: 1.04-1.27), and suvorexant was the replacement drug (odds ratios: 2.983; 95% CI: 1.44-6.19), which were significant predictors of good response. CONCLUSION: Although this is a retrospective and observational study with many limitations, our study results suggest that lemborexant is effective and safe.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Sleep medicine: X
- 巻
- 5
- 号
- 開始ページ
- 100070
- 終了ページ
- 100070
- 出版年月
- 2023年12月
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1016/j.sleepx.2023.100070
- 共同研究・競争的資金等の研究課題
研究者
吉川 茜
(ヨシカワ アカネ)