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論文
- タイトル
- タイトル（英）
- Identical tau filaments in subacute sclerosing panencephalitis and chronic traumatic encephalopathy.
- 参照URL
- https://researchmap.jp/masatohasegawa/published_papers/42267966
- 著者
- 著者（英）
- Chao Qi,Masato Hasegawa,Masaki Takao,Motoko Sakai,Mayasuki Sasaki,Masashi Mizutani,Akio Akagi,Yasushi Iwasaki,Hiroaki Miyahara,Mari Yoshida,Sjors H W Scheres,Michel Goedert
- 担当区分
- 概要
- 概要（英）
- Subacute sclerosing panencephalitis (SSPE) occurs in some individuals after measles infection, following a symptom-free period of several years. It resembles chronic traumatic encephalopathy (CTE), which happens after repetitive head impacts or exposure to blast waves, following a symptom-free period. As in CTE, the neurofibrillary changes of SSPE are concentrated in superficial cortical layers. Here we used electron cryo-microscopy (cryo-EM) of tau filaments from two cases of SSPE to show that the tau folds of SSPE and CTE are identical. Two types of filaments were each made of two identical protofilaments with an extra density in the β-helix region. Like in CTE, the vast majority of tau filaments were Type I, with a minority of Type II filaments. These findings suggest that the CTE tau fold can be caused by different environmental insults, which may be linked by inflammatory changes.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Acta neuropathologica communications
- 巻
- 11
- 号
- 1
- 開始ページ
- 74
- 終了ページ
- 74
- 出版年月
- 2023年5月5日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1186/s40478-023-01565-2
- 共同研究・競争的資金等の研究課題
研究者
Hasegawa Masato
( )