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論文
- タイトル
- タイトル（英）
- Neuroprotection and axon regeneration by novel low-molecular-weight compounds through the modification of DOCK3 conformation.
- 参照URL
- https://researchmap.jp/takayukiharada/published_papers/42361874
- 著者
- 著者（英）
- Kazuhiko Namekata,Naoki Tsuji,Xiaoli Guo,Euido Nishijima,Sari Honda,Yuta Kitamura,Atsushi Yamasaki,Masamichi Kishida,Jun Takeyama,Hirokazu Ishikawa,Youichi Shinozaki,Atsuko Kimura,Chikako Harada,Takayuki Harada
- 担当区分
- 概要
- 概要（英）
- Dedicator of cytokinesis 3 (DOCK3) is an atypical member of the guanine nucleotide exchange factors (GEFs) and plays important roles in neurite outgrowth. DOCK3 forms a complex with Engulfment and cell motility protein 1 (Elmo1) and effectively activates Rac1 and actin dynamics. In this study, we screened 462,169 low-molecular-weight compounds and identified the hit compounds that stimulate the interaction between DOCK3 and Elmo1, and neurite outgrowth in vitro. Some of the derivatives from the hit compound stimulated neuroprotection and axon regeneration in a mouse model of optic nerve injury. Our findings suggest that the low-molecular-weight DOCK3 activators could be a potential therapeutic candidate for treating axonal injury and neurodegenerative diseases including glaucoma.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Cell death discovery
- 巻
- 9
- 号
- 1
- 開始ページ
- 166
- 終了ページ
- 166
- 出版年月
- 2023年5月15日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1038/s41420-023-01460-8
- 共同研究・競争的資金等の研究課題